小林正典

研究者氏名	小林正典
	コバヤシマサノリ
所属	日本獣医生命科学大学
部署	獣医学部
職名	准教授
学位	博士（獣医学）(日本獣医生命科学大学)
J-Global ID	201601020659238874

委員歴

2023年4月

現在

動物臨床研究所生殖器・繁殖分科会顧問

2021年4月

現在

日本獣医学会獣医繁殖分科会評議委員

論文

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Establishment of a BRAF V595E-mutant canine prostate cancer cell line and the antitumor effects of MEK inhibitors against canine prostate cancer.

Masanori Kobayashi Moe Onozawa Shiho Watanabe Tomokazu Nagashima Kyoichi Tamura Yoshiaki Kubo Akiko Ikeda Kazuhiko Ochiai Masaki Michishita Makoto Bonkobara Masato Kobayashi Tatsuya Hori Eiichi Kawakami

Veterinary and comparative oncology 21(2) 221-230 2023年2月 [査読有り]

Canine prostate cancer (cPCa) is a malignant neoplasm with no effective therapy. The BRAF V595E mutation, corresponding to the human BRAF V600E mutation, is found frequently in cPCa. Activating BRAF mutations are recognized as oncogenic drivers, a...

Histopathological Characterization and Expression of Vitamin D Receptor in the Prostate of Healthy Dogs and Dogs with Prostatic Carcinoma

Akiko Ikeda Masanori Kobayashi Tatsuya Hori Masaki Michishita Masato Kobayashi Eiichi Kawakami

American Journal of Animal and Veterinary Sciences 18(1) 47-51 2023年1月 [査読有り]

Vitamin D Receptor (VDR) expression is implicated in human Prostatic Carcinoma (PC), but its role in canine PC is unclear. To investigate how VDR expression is affected by age and castration in healthy dogs and how it changes with PC, we evaluated...

Quality of cauda epididymal sperm immediately after collection and after freezing-thawing from Amur leopard cats (Prionailurus bengalensis euptilurus) and a local population of the subspecies Tsushima leopard cats.

Tatsuya Hori Hideo Tajima Shinichi Sasaki Mizuki Karasawa Madoka Yoshizawa Takuya Kuribara Hidemasa Hori Fujio Yamamoto Etsuo Narushima Kiyoshi Nagai Kazuaki Nippashi Yurie Sataka Masato Kobayashi Masanori Kobayashi Toshihiko Tsutsui

The Journal of veterinary medical science 85(1) 117-122 2022年11月 [査読有り]

In this study, cauda epididymal sperm were collected from Amur leopard cats with various causes of death as well as Tsushima leopard cats that underwent castration surgery, and sperm quality was compared with that in domestic cats. A sufficient nu...

Relaxin contributes to the elevation of monocytic myeloid-derived suppressor cells in peripheral blood of pregnant canines.

Masato Kobayashi Honami Sekine Yushi Ogawa Shin Toyama Yuki Komukai Moto Nakamura Ryusuke Mitanda Marina Hayashi Masanori Kobayashi Tatsuya Hori

Journal of reproductive immunology 155 103778-103778 2022年11月 [査読有り]

Tolerance towards fetal alloantigens in the maternal immune system is essential for maintaining pregnancy. Myeloid-derived suppressor cells (MDSCs) are immature myeloid cells characterized by their ability to suppress immune activity and maintain ...

Effect of supplementation with the reduced form of coenzyme Q10 on semen quality and antioxidant status in dogs with poor semen quality: Three case studies.

Masanori Kobayashi Chie Tsuzuki Marika Kobayashi Hinano Tsuchiya Yume Yamashita Kanako Ueno Moe Onozawa Masato Kobayashi Eiichi Kawakami Tatsuya Hori

The Journal of veterinary medical science 83(7) 1044-1049 2021年7月 [査読有り]

Oxidative stress owing to an imbalance between reactive oxygen species and antioxidants, such as coenzyme Q10 (CoQ10), is a major contributor to male infertility. We investigated the effects of the reduced form of CoQ10 (ubiquinol) supplementation...