Journal of Veterinary Medical Science 75(4) 523-526 2013年5月 [査読有り]
Puberty onset in mammals is tightly coupled to the animal's nutritional and metabolic state. In the present study, we evaluated the effects of a high-fat diet on leptin and adiponectin levels, leptin mRNA expression and puberty onset in female rat...
A peptide pheromone of the red-bellied male newt, sodefrin was tested for its ability to increase intracellular concentrations of Ca2+ ([Ca2+]i) in the dissociated vomeronasal (VN) cells of females by means of calcium imaging system. The pheromone...
Hormones and Behavior 62(4) 375-380 2012年9月 [査読有り]
Reproductive behavior in amphibians, as in other vertebrate animals, is controlled by multiple hormones. A neurosteroid, 7α-hydroxypregnenolone, has recently been found to enhance locomotor activity in the male newt, Cynops pyrrhogaster. Here, we ...
Yoshihiro Wakabayashi, Tomoaki Nakada, Ken Murata, Ken Murata, Satoshi Ohkura, Kazutaka Mogi, Kazutaka Mogi, Victor M. Navarro, Donald K. Clifton, Yuji Mori, Hiroko Tsukamura, Kei Ichiro Maeda, Robert A. Steiner, Robert A. Steiner, Hiroaki Okamura
Journal of Neuroscience 30(8) 3124-3132 2010年2月 [査読有り]
Gonadotropin-releasing hormone (GnRH) neurons in the basal forebrain are the final common pathway through which the brain regulates reproduction. GnRH secretion occurs in a pulsatile manner, and indirect evidence suggests the kisspeptin neurons in...
Olfactory response to the abdominal gland-derived steroids in the newt, Cynops pyrrhogaster
We investigated the effects of a bioartificial endocrine pancreas (Bio-AEP) produced by mouse β cells on sexual dysfunction of streptozotocin (STZ)-induced diabetic female rats. Female rats were administered STZ (60 mg/kg BW, i.v.) at the age of 1...
Misao Terada, Misao Terada, Mark Oláh, György M. Nagy, Kazumi Taniguchi, Fumio Sato, Shiro Muranaka, Wirasak Fungfuang, Pudcharaporn Kromkhun, Pudcharaporn Kromkhun, Tomoaki Nakada, Makoto Yokosuka, Toru R. Saito
Reproductive Medicine and Biology 9 205-209 2010年12月 [査読有り]
Purpose: The dopamine-derived endogenous compound, R-salsolinol (SAL), was recently identified as a putative endogenous prolactin (PRL)-releasing factor. However, how SAL influences copulatory behavior is unknown. In this study, we examined the re...
General and Comparative Endocrinology 151(3) 252-258 2007年5月 [査読有り]
Three types of cDNA encoding the arginine vasotocin (AVT) receptors from the newt, Cynops pyrrhogaster were cloned and the gene expression of each receptor analyzed in the organs and tissues of the newt. The deduced amino acid sequence of one type...
Tomoaki Nakada, Yoko Ishizuka, Takeo Iwata, Fumiyo Toyoda, Takashi Kato, J. Michael Conlon, Sakae Kikuyama, Sakae Kikuyama
Zoological Science 24(5) 521-524 2007年5月 [査読有り]
Sodefrin (Ser-Ile-Pro-Ser-Lys-Asp-Ala-Leu-Leu-Lys) is a female-attracting peptide pheromone secreted by the abdominal gland of the male red-bellied newt, Cynops pyrrhogaster. Sequence analysis of a cDNA encoding sodefrin revealed that the peptide ...
Tomoaki Nakada, Fumiyo Toyoda, Takeo Iwata, Kazutoshi Yamamoto, J. Michael Conlon, Takashi Kato, Sakae Kikuyama
Peptides 28(4) 774-780 2007年4月 [査読有り]
Previous analysis of PCR products derived from total RNA from the abdominal gland of the male newt, Cynops pyrrhogaster, inhabiting the Nara area of Japan led to the identification of a gene encoding [Val8]sodefrin, as well as the female-attractin...
Distribution of two types of arginine vasotocin receptor in the newt brain
Takeo Iwata, Yoko Ishizuka, Tomoaki Nakada, Fumiyo Toyoda, Kazutoshi Yamamoto, John M. Conlon, Sakae Kikuyama, Sakae Kikuyama
Annals of the New York Academy of Sciences 1040 351-353 2005年7月
Sodefrin (SIPSKDALLK) is a female-attracting pheromone that is secreted by the abdominal gland of the male red-bellied newt. We found that mRNA encoding a sodefrin variant, [Val8] sodefrin, is expressed exclusively in specimens captured in the Nar...
Sakae Kikuyama, Sakae Kikuyama, Tomoaki Nakada, Fumiyo Toyoda, Takeo Iwata, Kazutoshi Yamamoto, J. Michael Conlon
Annals of the New York Academy of Sciences 1040 123-130 2005年7月 [査読有り]
Amphibian sex pheromones of 3 urodele (Cynops pyrrhogaster, C. ensicauda, and Plethodon jordani) and 1 anuran (Litoria splendida) species have been isolated and characterized and found to be either small peptides or larger proteins. Each pheromone...
Occurrence of a biologically active sodefrin variant in the abdominal gland of male newts inhabiting in Nara
Takeo Iwata, J. Michael Conlon, Tomoaki Nakada, Fumiyo Toyoda, Kazutoshi Yamamoto, Sakae Kikuyama
Peptides 25 1537-1543 2004年9月 [査読有り]
Peptides derived from the post-translational processing of preprosodefrin were isolated from an extract of the abdominal glands of male red-bellied newts Cynops pyrrhogaster obtained 5 months prior to the onset of the breeding season. Structural c...
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