MOLECULAR AND CELLULAR NEUROSCIENCE 80 89-99 2017年4月 [査読有り]
Parkin is an E3 ubiquitin ligase whose mutations cause autosomal recessive juvenile Parkinson's disease (PD). Unlike the human phenotype, parkin knockout (KO) mice show no apparent dopamine neuron degeneration, although they demonstrate reduced ex...
Miyuki Kabayama   Kazuto Sakoori   Kazuyuki Yamada   Veravej G. Ornthanalai   Maya Ota   Naoko Morimura   Kei-ichi Katayama   Niall P. Murphy   Jun Aruga   
JOURNAL OF NEUROSCIENCE 33(32) 12940-12953 2013年8月 [査読有り]
Monoamine oxidase A (MAO-A), the catabolic enzyme of norepinephrine and serotonin, plays a critical role in emotional and social behavior. However, the control and impact of endogenous MAO-A levels in the brain remains unknown. Here we show that t...
We identified and characterized a novel RING finger gene, Rines/RNF180, which is well conserved among vertebrates. Putative Rines gene product (Rines) contains a RING finger domain, a basic coiled-coil domain, a novel conserved domain (DSPRC) and ...
We studied a series of 42 cases of transposition of the great arteries (TGA), a complex heart defect (CHD) that is two times more prevalent in males than in females. A mutation in the X chromosome at the ZIC3 gene was found in two affected sibling...
JOURNAL OF NEUROSCIENCE 27(20) 5461-5473 2007年5月 [査読有り]
The medial telencephalon is a source of neurons that follow distinct tangential trajectories of migration to various structures such as the cerebral cortex, striatum, and olfactory bulb. In the present study, we characterized the forebrain anomali...