AMERICAN JOURNAL OF PATHOLOGY 186(5) 1302-1312 2016年5月 [査読有り]
Duchenne muscular dystrophy is a lethal X-Linked muscle disorder. We have already reported that osteopontin (OPN), an inflammatory cytokine and myogenic factor, is expressed in the early dystrophic phase in canine X-Linked muscular dystrophy in Ja...
Bailey Miskew Nichols Yoshitsugu Aoki Mutsuki Kuraoka Joshua J. A. Lee Shin'ichi Takeda Toshifumi Yokota
JOVE-JOURNAL OF VISUALIZED EXPERIMENTS 24(111) 2016年5月 [査読有り]
Duchenne muscular dystrophy (DMD) is one of the most common lethal genetic diseases worldwide, caused by mutations in the dystrophin (DMD) gene. Exon skipping employs short DNA/RNA-like molecules called antisense oligonucleotides (AONs) that resto...
Janek Hyzewicz Jun Tanihata Mutsuki Kuraoka Naoki Ito Yuko Miyagoe-Suzuki Shin'ichi Takeda
FREE RADICAL BIOLOGY AND MEDICINE 82 122-136 2015年5月 [査読有り]
High intensity training induces muscle damage in dystrophin-deficient mdx mice, an animal model for Duchenne muscular dystrophy. However, low intensity training (LIT) rescues the mdx phenotype and even reduces the level of protein carbonylation, a...
The molecular mechanism of muscle degeneration in a lethal muscle disorder Duchene muscular dystrophy (DMD) has not been fully elucidated. The dystrophic dog, a model of DMD, shows a high mortality rate with a marked increase in serum creatine kin...
K. Nishimura M. Ishii M. Kuraoka K. Kamimura N. Maeda
NEUROSCIENCE 169(4) 1535-1547 2010年9月 [査読有り]
Axon-dendrite polarity of neurons is essential for information processing in the nervous system. Here we studied the functions of chondroitin sulfate (CS) and heparan sulfate (HS) in neuronal polarization using cultured dissociated hippocampal neu...
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獣医学部