小柳円

研究者氏名	小柳円
	コヤナギマドカ
URL	https://kaken.nii.ac.jp/d/r/00543399.ja.html
所属	日本獣医生命科学大学
部署	応用生命科学部動物科学科
職名	准教授
J-Global ID	201601013591655505

研究キーワード

ストレス ,HIV-1 ,CTL

研究分野

ライフサイエンス / 免疫学 /

経歴

12 >

2020年4月

現在

日本獣医生命科学大学応用生命科学部動物科学科准教授

2016年4月

2020年3月

日本獣医生命科学大学応用生命科学部動物科学科講師

2014年4月

2016年3月

日本獣医生命科学大学応用生命科学部動物科学科助教

2009年2月

2014年3月

熊本大学エイズ学研究センター特任助教

2006年3月

2009年1月

St.Jude Children’s Research Hospital Department of Immunology 研究員

学歴

2000年4月

2004年3月

東京女子医科大学大学院医学研究科微生物学免疫学分野

1998年4月

2000年3月

北里大学大学院医科学研究科生体機能医科学群

論文

<3 456 7 >

Selection of escape mutant by HLA-C-restricted HIV-1 Pol-specific cytotoxic T lymphocytes carrying strong ability to suppress HIV-1 replication

Kazutaka Honda Nan Zheng Hayato Murakoshi Masao Hashimoto Keiko Sakai Mohamed Ali Borghan Takayuki Chikata Madoka Koyanagi Yoshiko Tamura Hiroyuki Gatanaga Shinichi Oka Masafumi Takiguchi

EUROPEAN JOURNAL OF IMMUNOLOGY 41(1) 97-106 2011年1月 [査読有り]

HIV-1 mutants escaping from HLA-A-or HLA-B-restricted CTL have been well studied, but those from HLA-C-restricted CTL have not. Therefore we investigated the ability of HLA-C-restricted CTL to select HIV-1 escape mutants. In the present study, we ...

Diversifying selection and functional analysis of interleukin-4 suggests antagonism-driven evolution at receptor-binding interfaces

Madoka Koyanagi Julie A. Kerns Linda Chung Yan Zhang Scott Brown Tudor Moldoveanu Harmit S. Malik Mark Bix

BMC EVOLUTIONARY BIOLOGY 10 223 2010年7月 [査読有り]

Background: Interleukin-4 (IL4) is a secreted immunoregulatory cytokine critically involved in host protection from parasitic helminths [1]. Reasoning that helminths may have evolved mechanisms to antagonize IL4 to maximize their dispersal, we exp...

Reduced T cell expansion by a superantigen as a result of impaired B cell development in mice deficient for the p85 alpha regulatory subunit of PI3K

Yutaka Arimura Taichi Ezaki Madoka Koyanagi Takehiko Uchiyama Shigeo Koyasu Junji Yagi

JOURNAL OF LEUKOCYTE BIOLOGY 87(3) 493-500 2010年3月 [査読有り]

PI3K plays crucial roles in the immune system. Mice deficient for p85 alpha, a major regulatory subunit of class IA PI3K, show various defects and alterations in B cells, mast cells, macrophages, and DCs, and peripheral T cells are reportedly norm...

Cutting Edge: Dab2 Is a FOXP3 Target Gene Required for Regulatory T Cell Function

Nitya Jain Hai Nguyen Randall H. Friedline Nidhi Malhotra Michael Brehm Madoka Koyanagi Mark Bix Jonathan A. Cooper Cynthia A. Chambers Joonsoo Kang

JOURNAL OF IMMUNOLOGY 183(7) 4192-4196 2009年10月 [査読有り]

FOXP3-expressing regulatory T (Treg) cells are vital for maintaining peripheral T cell tolerance and homeostasis. The mechanisms by which FOXP3 target genes orchestrate context-dependent Treg cell function are largely unknown. In this study we sho...

Mina, an Il4 repressor, controls T helper type 2 bias

Mariko Okamoto Melanie Van Stry Linda Chung Madoka Koyanagi Xizhang Sun Yoshie Suzuki Osamu Ohara Hiroshi Kitamura Atsushi Hijikata Masato Kubo Mark Bix

NATURE IMMUNOLOGY 10(8) 872-U98 2009年8月 [査読有り]

T helper type 2 (T(H)2) bias, which is the propensity of naive CD4(+) T cells to differentiate into interleukin 4 (IL-4)-secreting T(H)2 cells, is a genetic trait that affects susceptibility to infectious, autoimmune and allergic diseases. T(H)2 b...