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研究者リスト >> 藤澤正彦
 

藤澤正彦

 
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研究者氏名藤澤正彦

論文

 
Maruyama M, Fujisawa M, Yokosuka M, Saito TR, Hayama SI, Akimoto T, Hakamata Y
Experimental animals   65(4) 447-454   2016年11月   [査読有り]
Yasuaki Tsuchida, Yasuaki Tsuchida, Fumihiko Hatao, Masahiko Fujisawa, Takahisa Murata, Michio Kaminishi, Yasuyuki Seto, Masatoshi Hori, Hiroshi Ozaki
Gut   60 638-647   2011年5月
Background: The main symptom of postoperative ileus (POI) is an intestinal motility disorder in which monocytes/macrophages and neutrophils play crucial roles. Prokinetic 5-hydroxytryptamine 4 receptor (5-HT4R) agonists and dopamine receptor antag...
Masahiko Fujisawa, Takahisa Murata, Masatoshi Hori, Hiroshi Ozaki
Journal of Gastroenterology   45 179-186   2010年2月
Background: The cholinergic anti-inflammatory pathway is a novel physiological mechanism found at various locations in the body where the nicotinic regulation of inflammatory cells through the autonomic nervous system is involved. In this study, w...
Takashi Ohama, Masatoshi Hori, Masahiko Fujisawa, Masaharu Kiyosue, Masaki Hashimoto, Yuka Ikenoue, Yoshio Jinno, Hiroto Miwa, Takayuki Matsumoto, Takahisa Murata, Hiroshi Ozaki
Journal of Gastroenterology   43 858-865   2008年11月
Background: Chronic intestinal inflammation is frequently accompanied by motility disorders. We previously reported that proinflammatory cytokines, such as tumor necrosis factor α and interleukin (IL)-1β downregulate CPI-17, an endogenous inhibito...
M. S. Islam, T. Murata, M. Fujisawa, R. Nagasaka, H. Ushio, A. M. Bari, M. Hori, H. Ozaki, H. Ozaki
British Journal of Pharmacology   154 812-824   2008年6月
Background and purpose: We have recently reported that phytosteryl ferulates isolated from rice bran inhibit nuclear factor-κB (NF-κB) activity in macrophages. In the present study, we investigated the effect of γ-oryzanol (γ-ORZ), a mixture of ph...
Z. Zhao, Z. Zhao, H. Satsu, M. Fujisawa, M. Hori, Y. Ishimoto, M. Totsuka, A. Nambu, S. Kakuta, H. Ozaki, M. Shimizu
Amino Acids   35 217-224   2008年6月
The effects of dietary taurine on the experimental colitis induced by dextran sulfate sodium (DSS) in mice were evaluated. C57BL/6 female mice were given 3% DSS in drinking water for 5 d to induce acute colitis. Taurine at 2% was added to the drin...
Takuo Mizukami, Takuo Mizukami, Yoshiakira Kanai, Masahiko Fujisawa, Masami Kanai-Azuma, Masamichi Kurohmaru, Yoshihiro Hayashi
Molecular Reproduction and Development   75 1002-1010   2008年6月
In mammals, Sry, Sox9, and M33 act as regulators at a chromatin level and promote the maturation of embryonic gonads into testes. Recently, it was shown that transcriptional regulation by DNA methylation plays crucial roles in gene expression duri...
Kazuya Kinoshita, Kazuhide Horiguchi, Masahiko Fujisawa, Fuyu Kobirumaki, Shigeru Yamato, Masatoshi Hori, Hiroshi Ozaki
Histochemistry and Cell Biology   127 41-53   2007年1月
Resident macrophages are distributed in the network of interstitial cells of Cajal (ICC) and the myenteric nerve within the myenteric plexus. We evaluated changes in chemoattractant protein mRNA expression in macrophages and neutrophils, the ICC, ...
M. Kiyosue, M. Fujisawa, K. Kinoshita, M. Hori, H. Ozaki, H. Ozaki
Neurogastroenterology and Motility   18 1019-1030   2006年11月
We examined the time-dependent changes in the immunoreactivity of the smooth muscle region and the accompanying motility disorder in a hapten-induced rat model of colitis. Histological analysis and myeloperoxidase (MPO) activity indicated that inf...
Masahiko Fujisawa, Masaharu Kiyosue, Masatoshi Hori, Hiroshi Ozaki, Hiroshi Ozaki
Journal of Veterinary Medical Science   68 701-708   2006年8月
Card15/Nod2 has been suggested to be an intracellular pathogen-associated molecular pattern (PAMPs) recognition molecule, which contains a leucine-rich repeat region similar to the Toll-like receptors (TLRs). Card15/Nod2 gene variants play an impo...
K. Kinoshita, M. Hori, M. Fujisawa, K. Sato, T. Ohama, E. Momotani, H. Ozaki, H. Ozaki
Neurogastroenterology and Motility   18 578-588   2006年7月
Macroscopic and histological analysis revealed that the colonic inflammation induced by 2,4,6-trinitrobenzenesulphonic acid (TNBS) was of lower grade in tumour necrosis factor-α (TNF-α)-/- mice than in wild-type mice. Myeloperoxidase activity, an ...
Tomohide Kidokoro, Shogo Matoba, Ryuji Hiramatsu, Masahiko Fujisawa, Masami Kanai-Azuma, Choji Taya, Masamichi Kurohmaru, Hayato Kawakami, Yoshihiro Hayashi, Yoshiakira Kanai, Hiromichi Yonekawa
Developmental Biology   278 511-525   2005年2月
Testis induction is associated with gonadal Sry and Sox9 expression in mammals. This study investigated whether Sry expression directly induces male-specific Sox9 activation during early phases of testis differentiation. We have established an XX ...
Masahiko Fujisawa, Yoshiakira Kanai, Sang Yoon Nam, Seishi Maeda, Nobuaki Nakamuta, Kiyoshi Kano, Masamichi Kurohmaru, Yoshihiro Hayashi
Journal of Reproduction and Development   50 565-570   2004年12月
The Prnp (prion protein) gene, which encodes a soluble protein anchored to the cell surface by glycosylphosphatidylinositol (GPI), might be involved in cell-to-cell interaction. The expression of Prnp is strongly observed not only in the brain, bu...
Takuo Mizukami, Masahiko Fujisawa, Yoshiakira Kanai, Masamichi Kurohmaru, Yoshihiro Hayashi
Journal of Reproduction and Development   50 227-235   2004年12月
Sry, Sox9 and M33 are thought to act as architectural transcription factors or as a chromatin regulator in gonadal development. However, the direct relationship between chromatin structure and sex determination has not yet been revealed. To clarif...
Takashi Noma, Yoshiakira Kanai, Masami Kanai-Azuma, Maki Ishii, Masahiko Fujisawa, Masamichi Kurohmaru, Hayato Kawakami, Stephen A. Wood, Stephen A. Wood, Yoshihiro Hayashi
Mechanisms of Development   119    2002年12月
During the Drosophila oogenic processes, Fat facets (Faf), an ubiquitin-specific protease essential for normal development of oocyte and eye, becomes localized at the posterior pole and is incorporated into the pole cells. This is dependent on Osk...
Takashi Noma, Yoshiakira Kanai, Masami Kanai-Azuma, Maki Ishii, Masahiko Fujisawa, Masamichi Kurohmaru, Hayato Kawakami, Stephen A. Wood, Stephen A. Wood, Yoshihiro Hayashi
Gene Expression Patterns   2 87-91   2002年11月
During the Drosophila oogenic processes, Fat facets (Faf), an ubiquitin-specific protease essential for normal development of oocyte and eye, becomes localized at the posterior pole and is incorporated into the pole cells. This is dependent on Osk...
H. Endo, H. Endo, T. Morigaki, M. Fujisawa, D. Yamagiwa, M. Sasaki, M. Sasaki, J. Kimura, J. Kimura
Anatomia, Histologia, Embryologia   28 303-305   1999年12月
The intestinal tract of the white rhinoceros (Ceratotherium simum) was dissected. We observed a simple structure for the small intestine, duodenum, jejunum and ileum, and a well-developed large intestine, cecum, colon and rectus. The cecum consist...
K. Kano, A. Notani, S. Y. Nam, M. Fujisawa, M. Kurohmaru, Y. Hayashi
The Journal of veterinary medical science / the Japanese Society of Veterinary Science   61 213-219   1999年3月
Following stimulation by the transforming growth factor-beta (TGF-beta) family in the cytoplasm, the Smad family is phosphorylated and translocated to the nucleus and activates several gene transcriptions. In this study, the mouse Smad3 cDNA inclu...
H. Endo, Manglai, M. Fujisawa, M. Kurohmaru, Y. Hayashi
Anatomia, Histologia, Embryologia   27 327-330   1998年12月
The nasopharynx and eustachian tube (auditory tube) were morphologically examined in the white rhinoceros. The narrow nasopharynx cavity was enlarged dorsoventrally. The most lateral part of both sides sharply rises in a dorsal direction and the v...
Sang Yoon Nam, Seishi Maeda, Masahiko Fujisawa, Masamichi Kurohmaru, Yoshihiro Hayashi
Journal of Veterinary Medical Science   60 1175-1179   1998年11月
Mitochondnal capsule selenoprotein (MCS) has been known as a structural protein of the mitochondrial sheath in spermatozoa. In the present study, to determine the expression pattern of MCS mRNA in the hamster testis. northern blot and in situ hybr...
Sang Yoon Nam, Seishi Maeda, Masahiko Fujisawa, Masamichi Kurohmaru, Yoshihiro Hayashi
Journal of Veterinary Medical Science   60 1113-1118   1998年10月
Mitochondrial capsule selenoprotein (MCS) has been known as a structural protein of the mitochondrial sheath in spermatozoa. In the present study, a full-length cDNA encoding the MCS was first isolated from the testes of 10-week-old golden hamster...
Seishi Maeda, Sang Yoon Nam, Masahiko Fujisawa, Nobuaki Nakamuta, Kenji Ogawa, Masamichi Kurohmaru, Yoshihiro Hayashi
Cell Structure and Function   23 169-178   1998年6月
We obtained three kinds of novel cytoplasmic dynein light-intermediate chain (LIC) isoforms from rat testis and brain by reverse transcription polymerase chain reaction (RT-PCR). The primers for RT-PCR were designed according to LIC-2 (LIC 53/55) ...
Sang Yoon Nam, Masahiko Fujisawa, Jong Soo Kim, Masamichi Kurohmaru, Yoshihiro Hayashi
Biology of Reproduction   58 1272-1276   1998年5月
To determine the expression pattern of phospholipid hydroperoxide glutathione peroxidase (PHGPx) mRNA in testes, Northern (3-, 8-, 40-, and 80- wk-old mice) and in situ (8-wk-old mice) hybridization analyses using digoxigenin-labeled RNA probes fo...
Seishi Maeda, Seishi Maeda, Sang Yoon Nam, Masahiko Fujisawa, Nobuaki Nakamuta, Kenji Ogawa, Masamichi Kurohmaru, Yoshihiro Hayashi
Cell Structure and Function   23 9-15   1998年2月
Expression of cytoplasmic dynein light-intermediate chain mRNA in the rat testis was examined using in situ hybridization. The ribonucleotide probe, referred to the 5' end of open reading frame (6-515 nucleotids) of cytoplasmic dynein light-interm...
Hideki Endo, Daishiro Yamagiwa, Masahiko Fujisawa, Junpei Kimura, Masamichi Kurohmaru, Yoshihiro Hayashi
Annals of Anatomy   179 481-485   1997年1月
The muscular and skeletal systems of the long neck were morphologically examined in order to clarify their modification and their functional significance in the giraffe (Giraffa camelopardalis). The longissimus, the thoracic and cervical, spinalis...

Misc

 
堀 正敏, 藤澤 正彦, 尾崎 博
日本薬理学雑誌 : FOLIA PHARMACOLOGICA JAPONICA   128(2) 72-77   2006年8月
クローン病や潰瘍性大腸炎などの炎症性腸疾患(inflammatory bowel disease:IBD)では重篤な消化管運動機能障害を発症するが,これは腸内環境の悪化を招いて粘膜炎症をさらに悪化させる.すなわち,消化管運動機能の改善は疾患の治癒や緩解にとって極めて重要な治療ステップと考えられている.この消化管運動機能障害はIBDに限定されるものではなく,腸閉塞など様々な原因で生じる腸炎や,外科手術後の消化管機能障害(post-operative ileus:POI),敗血症などで広く認め...
尾崎 博, 藤沢 正彦
日本薬理学雑誌 : FOLIA PHARMACOLOGICA JAPONICA   126(2)    2005年8月
牧田登之, 藤沢正彦, 山根哲也, SO K, MAO R, 林良博
山口獣医学雑誌   (29) 19-24   2002年12月
牧田登之, 藤沢正彦, 山根哲也, SO K, ぼう来, 林良博
山口獣医学雑誌   (29) 11-18   2002年12月
金井克晃, 水上拓郎, 金井正美, 平松竜司, 城所知秀, 藤沢正彦, 九郎丸正道, 林良博
日本比較内分泌学会ニュース   (106) 14-21   2002年8月

講演・口頭発表等

 
上村静香, 片岡雅晴, 平出貴裕, 寺谷俊昭, 藤澤正彦, 袴田陽二
日本実験動物学会総会講演要旨集   2018年4月27日   
藤澤正彦, 橘侑里, 華園沙弥香, 袴田陽二
日本実験動物学会総会講演要旨集   2018年4月27日   
藤澤正彦, 橘侑里, 袴田陽二
日本獣医学会学術集会講演要旨集   2017年8月30日   
大坂優衣, 藤澤正彦, 寺谷工, 丸山基世, 袴田陽二
再生医療   2015年2月1日   
大坂優衣, 藤澤正彦, 寺谷工, 丸山基世, 袴田陽二
日本獣医学会学術集会講演要旨集   2014年8月11日   
藤澤正彦, 大坂優衣, 丸山基世, 袴田陽二
日本実験動物学会総会講演要旨集   2014年5月1日   
荒井香南, 大坂優衣, 藤澤正彦, 袴田陽二
日本実験動物学会総会講演要旨集   2014年5月1日   
大坂優衣, 藤澤正彦, 寺谷工, 丸山基世, 袴田陽二
日本実験動物学会総会講演要旨集   2014年5月1日   
丸山基世, 藤澤正彦, 横須賀誠, 斎藤徹, 藤平篤志, 天尾弘実, 羽山伸一, 袴田陽二
日本獣医学会学術集会講演要旨集   2012年8月31日   
丸山基世, 藤澤正彦, 横須賀誠, 斎藤徹, 羽山伸一, 袴田陽二
日本実験動物学会総会講演要旨集   2012年5月1日   

所属学協会

 
日本再生医療学会 , 日本潰瘍学会 , 日本実験動物学会 , 日本獣医学会