We recently advocated in favour of naming a novel H2-haplotype consisting of Kd , D/Ldm7 , I-Ak and I-Ek in the atopic dermatitis (AD) mouse model NC/Nga as "H-2nc ." The role of the H2-haplotype in AD development was investigated in H2 b -congeni...
Kozo Ohkusu-Tsukada   Daiki Ito   Kimimasa Takahashi   
International Archives of Allergy and Immunology 176(2) 91-100 2018年5月 [査読有り]
Background: Although immunosuppressants for therapy of atopic dermatitis (AD) are still being sought, proteasome inhibitors are also potential candidates for the treatment of AD. Proteasome inhibitors exert various effects by blocking proteasomal ...
Y. Machida   M. Michishita   M. Wada   T. Hori   E. Kawakami   H. Yoshimura   K. Ohkusu-Tsukada   K. Taya   K. Takahashi   
JOURNAL OF COMPARATIVE PATHOLOGY 156(2-3) 178-182 2017年2月 [査読有り]
A 5-year-old female domestic shorthair cat was presented with abdominal distension and serum biochemical evaluation indicated a high concentration of oestradiol (32.81 pg/ml). Exploratory laparotomy revealed a large cystic mass in the right ovary ...
Ohkusu-Tsukada K   Tsukada T   Takahashi K   
Bioscience, biotechnology, and biochemistry 81(11) 2160-2163 2017年 [査読有り]
Superantigens (SAgs) are powerful T-cell stimulatory proteins. Because an atopic dermatitis (AD) model NC/Nga mice had two endogenous SAgs, namely minor lymphocyte-stimulating locus-1a (Mls-1a) and mouse mammary tumor virus (MMTV)(SHN), SAg-respon...
Rei Nakahira   Rumika Yoshida   Masaki Michishita   Kozo Ohkusu-Tsukada   Kimimasa Takahashi   
COMPARATIVE MEDICINE 66(1) 25-29 2016年2月 [査読有り]
Ganglion cell-like (GL) cells reside in the dermis of the ventral skin of mature male Djungarian hamsters (Phodopus sugorus) and express androgen receptor (AR). To assess whether GL cells have androgen-dependent behavior, we evaluated the histolog...