Y Ogasawara K Katayama A Minami M Otsuka T Eguchi K Kakinuma
CHEMISTRY & BIOLOGY 11(1) 79-86 2004年1月 [査読有り]
Vicenistatin, an antitumor antibiotic isolated from Streptomyces halstedii, is a unique 20-membered macrocyclic lactam with a novel aminosugar vicenisamine. The vicenistatin biosynthetic gene cluster (vin) spanning similar to64 kbp was cloned and ...
SG Kendrew K Katayama E Deutsch K Madduri CR Hutchinson
BIOCHEMISTRY 38(15) 4794-4799 1999年4月 [査読有り]
Mutations in the Streptomyces peucetius dnrD gene block the ring cyclization leading from aklanonic acid methyl ester (AAME) to aklaviketone (AK), an intermediate in the biosynthetic pathway to daunorubicin (DNR) and doxorubicin. To investigate th...
Journal of the Chemical Society - Perkin Transactions 1 (9) 1225-1232 1999年 [査読有り]
Advanced intermediates, prosolanapyrones I (6) and II (7) have been synthesized in deuterium labelled form and administered to cultures of Alternaria solani. Incorporation of [17,17,18,18,18-2H5]prosolanapyrone I (6b) afforded solanapyrones A (1) ...
H Oikawa T Kobayashi K Katayama Y Suzuki A Ichihara
JOURNAL OF ORGANIC CHEMISTRY 63(24) 8748-8756 1998年11月 [査読有り]
The syntheses of prosolanapyrones I (6) and II (7) via the aldol reactions of pyrone and dienal segments have been achieved in five steps in 31% overall yield for 6 and seven steps in 5% overall yield for 7. An improved synthetic route starting fr...
K Katayama T Kobayashi H Oikawa M Honma A Ichihara
BIOCHIMICA ET BIOPHYSICA ACTA-PROTEIN STRUCTURE AND MOLECULAR ENZYMOLOGY 1384(2) 387-395 1998年5月 [査読有り]
In cell-foe extracts of Alternaria solani, an enzymatic activity converting prosolanapyrone II to solanapyrones A and D via oxidation and subsequent Diels-Alder reaction has been found. Chromatography with DEAE-Sepharose provided two active fracti...
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獣医学部