Shuangding Wu, Sofie Vossius, Souad Rahmouni, Ana V. Miletic, Torkel Vang, Jesus Vazquez-Rodriguez, Fabio Cerignoli, Yutaka Arimura, Scott Williams, Tikva Hayes, Michel Moutschen, Stefan Vasile, Maurizio Pellecchia, Tomas Mustelin, Lutz Tautz
JOURNAL OF MEDICINAL CHEMISTRY 52(21) 6716-6723 2009年11月 [査読有り]
Loss of VHR phosphatase causes cell cycle arrest in HeLa carcinoma cells, suggesting that VHR inhibition may be a useful approach to halt the growth of cancer cells. We recently reported that V H R is upregulated in several cervix cancer cell line...
Jianxiu Yu, Sharon S. Zhang, Kan Saito, Scott Williams, Yutaka Arimura, Yuliang Ma, Yuehai Ke, Veronique Baron, Dan Mercola, Gen-Sheng Feng, Eileen Adamson, Tomas Mustelin
EMBO JOURNAL 28(1) 21-33 2009年1月 [査読有り]
The PTEN tumour suppressor gene is induced by the early growth response 1 (EGR1) transcription factor, which also transactivates p53, p73, and p300/CBP as well as other proapoptotic and anti-cancer genes. Here, we describe a novel Akt-EGR1-alterna...
We report that the protein tyrosine phosphatase PTP-PEST is expressed in resting human and mouse CD4(+) and CD8(+) T cells, but not in Jurkat T leukemia cells, and that PTP-PEST protein, but not mRNA, was dramatically downregulated in CD4(+) and C...
Torkel Vang, Ana V. Miletic, Yutaka Arimura, Lutz Tautz, Robert C. Rickert, Tomas Mustelin
ANNUAL REVIEW OF IMMUNOLOGY 26 29-55 2008年 [査読有り]
Protein tyrosine phosphatases (PTPs) are important regulators of many cellular functions and a growing number of PTPs have been implicated in human disease conditions, such as developmental defects, neoplastic disorders, and immunodeficiency. Here...
Konstantina Nika, Lutz Tautz, Yutaka Arimura, Torkel Vang, Scott Williams, Tomas Mustelin
JOURNAL OF BIOLOGICAL CHEMISTRY 282(49) 36000-36009 2007年12月 [査読有り]
Src family kinases are suppressed by a "tail bite" mechanism, in which the binding of a phosphorylated tyrosine in the C terminus of the protein to the Src homology (SH)2 domain in the N-terminal half of the protein forces the catalytic domain int...
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