We report that the protein tyrosine phosphatase PTP-PEST is expressed in resting human and mouse CD4(+) and CD8(+) T cells, but not in Jurkat T leukemia cells, and that PTP-PEST protein, but not mRNA, was dramatically downregulated in CD4(+) and C...
Torkel Vang Ana V. Miletic Yutaka Arimura Lutz Tautz Robert C. Rickert Tomas Mustelin
ANNUAL REVIEW OF IMMUNOLOGY 26 29-55 2008年 [査読有り]
Protein tyrosine phosphatases (PTPs) are important regulators of many cellular functions and a growing number of PTPs have been implicated in human disease conditions, such as developmental defects, neoplastic disorders, and immunodeficiency. Here...
Konstantina Nika Lutz Tautz Yutaka Arimura Torkel Vang Scott Williams Tomas Mustelin
JOURNAL OF BIOLOGICAL CHEMISTRY 282(49) 36000-36009 2007年12月 [査読有り]
Src family kinases are suppressed by a "tail bite" mechanism, in which the binding of a phosphorylated tyrosine in the C terminus of the protein to the Src homology (SH)2 domain in the N-terminal half of the protein forces the catalytic domain int...
The long-term exposure of mice to superantigen SEA using a mini-osmotic pump (SEA pump) induced a long-lasting expansion of V beta 3(+)CD4(+) T cells with T helper (Th) 2 cell-type properties. Removal of the SEA pump 10 days after pump implantatio...
Timothy J. Bauler Elizabeth D. Hughes Yutaka Arimura Tomas Mustelin Thomas L. Saunders Philip D. King
JOURNAL OF IMMUNOLOGY 178(6) 3680-3687 2007年3月 [査読有り]
PTPN3 (PTPH1) is a cytoskeletal protein tyrosine phosphatase that has been implicated as a negative regulator of early TCR signal transduction and T cell activation. To determine whether PTPN3 functions as a physiological negative regulator of TCR...
学長
応用生命科学部