金田剛治

研究者氏名	金田剛治

所属	日本獣医生命科学大学
部署	獣医学部
職名	教授
学位	博士（獣医学）(日本獣医畜産大学大学院)
J-Global ID	201501004729774245

研究キーワード

エネルギー代謝 ,ホスホジエステラーゼ阻害剤 ,平滑筋 ,ポリフェノール

研究分野

ライフサイエンス / 薬理学 /
ライフサイエンス / 獣医学 /

経歴

2018年4月

現在

日本獣医生命科学大学獣医学部獣医学科獣医薬理学研究室教授

2011年4月

2018年3月

日本獣医生命科学大学獣医学部獣医学科准教授

2006年4月

2011年3月

日本獣医生命科学大学獣医学部獣医学科講師

2002年4月

2006年3月

日本獣医畜産大学獣医学部獣医学科助手

学歴

1993年4月

1997年3月

日本獣医畜産大学大学院獣医学専攻博士課程

1987年4月

1993年3月

日本獣医畜産大学獣医畜産学部獣医学科

論文

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Aerobic metabolism on muscle contraction in porcine gastric smooth muscle

Hidenori Kanda Takeharu Kaneda Yuta Nagai Norimoto Urakawa Kazumasa Shimizu

Journal of Veterinary Medical Science 80(5) 846-850 2018年5月 [査読有り]

Exposure to chronic hypoxic conditions causes various gastric diseases, including gastric ulcers. It has been suggested that gastric smooth muscle contraction is associated with aerobic metabolism. However, there are no reports on the association ...

Imidazole-induced contractions in bovine tracheal smooth muscle are not dependent on the camp pathway

Takeharu Kaneda Hidenori Kanda Tsuyoshi Tajima Norimoto Urakawa Kazumasa Shimizu

Journal of Veterinary Medical Science 80(2) 341-345 2018年2月 [査読有り]

The mechanism of imidazole-induced contraction on the bovine tracheal smooth muscle was investigated. Imidazole induced muscle contraction in a concentration-dependent manner on bovine, porcine and guinea-pig tracheas, but not in rat or mouse. In ...

Angiotensin II, a unique vasoactive agent dissociates myosin light chain phosphorylation from contraction

Takashi Hirano Takeharu Kaneda Hiroshi Ozaki Masatoshi Hori

Journal of Veterinary Medical Science 80(2) 219-224 2018年2月 [査読有り]

Angiotensin II (100 nM) induced bi-phasic increases in cytosolic Ca2+ level ([Ca2+]i) through the activation of angiotensin II type 1 receptor. Pharmacological examinations using 10 µM verapamil, 30 µM La3+, and 1 µM thapsigargin indicated that th...

Inhibition of actin polymerization by marine toxin pectenotoxin-2

Masatoshi Hori Futoshi Yazama Yasuhiro Matsuura Ryo Yoshimoto Takeharu Kaneda Takeshi Yasumoto Hiroshi Ozaki Hideaki Karaki

Journal of Veterinary Medical Science 80(2) 225-234 2018年2月 [査読有り]

Pectenotoxin-2 (PCTX-2) is one of the polyether macrolide toxins isolated from scallops involved in diarrheic shellfish poisoning via actin depolymerization. In the present study, we examined the bioactive mechanism of PCTX-2 in smooth muscle cell...

Phosphodiesterase 9 (Pde9) regulates bovine tracheal smooth muscle relaxation

Tsuyoshi Tajima Tamami Shinoda Norimoto Urakawa Kazumasa Shimizu Takeharu Kaneda

Journal of Veterinary Medical Science 80(3) 499-502 2018年 [査読有り]

The present study was designed to clarify phosphodiesterase 9 (PDE9) expression in bovine tracheal smooth muscle tissue, and to elucidate that PDE9 may contribute to the regulation of airway relaxation. PDE9 mRNA expression was detected in bovine ...