氏家誠

研究者氏名	氏家誠

所属	日本獣医生命科学大学
部署	獣医学部獣医学科獣医感染症学研究室
職名	准教授
学位	博士（医学）(名古屋市立大学)
J-Global ID	201601020286651431

研究分野

ライフサイエンス / ウイルス学 /

論文

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Reverse Genetics with a Full-Length Infectious cDNA Clone of Bovine Torovirus.

Makoto Ujike Yuka Etoh Naoya Urushiyama Fumihiro Taguchi Hideki Asanuma Luis Enjuanes Wataru Kamitani

Journal of virology 96(3) e0156121 2022年2月 [査読有り]

Historically part of the coronavirus (CoV) family, torovirus (ToV) was recently classified in the new family Tobaniviridae. While reverse genetics systems have been established for various CoVs, none exist for ToVs. Here, we developed a reverse ge...

Recent Progress in Torovirus Molecular Biology.

Makoto Ujike Fumihiro Taguchi

Viruses 13(3) 2021年3月 [査読有り]

Torovirus (ToV) has recently been classified into the new family Tobaniviridae, although it belonged to the Coronavirus (CoV) family historically. ToVs are associated with enteric diseases in animals and humans. In contrast to CoVs, which are reco...

Characterization of Localization and Export Signals of Bovine Torovirus Nucleocapsid Protein Responsible for Extensive Nuclear and Nucleolar Accumulation and Their Importance for Virus Growth.

Makoto Ujike Yukako Kawachi Yui Matsunaga Yuka Etho Hideki Asanuma Wataru Kamitani Fumihiro Taguchi

Journal of virology 95(3) 2021年1月 [査読有り]

Torovirus (ToV) has recently been classified into the new family Tobaniviridae, although historically, it belonged to the Coronavirus (CoV) family. The nucleocapsid (N) proteins of CoVs are predominantly localized in the cytoplasm, where the virus...

The Inhaled Steroid Ciclesonide Blocks SARS-CoV-2 RNA Replication by Targeting the Viral Replication-Transcription Complex in Cultured Cells.

Shutoku Matsuyama Miyuki Kawase Naganori Nao Kazuya Shirato Makoto Ujike Wataru Kamitani Masayuki Shimojima Shuetsu Fukushi

Journal of virology 95(1) 2020年12月 [査読有り]

Here, we screened steroid compounds to obtain a drug expected to block host inflammatory responses and Middle East respiratory syndrome coronavirus (MERS-CoV) replication. Ciclesonide, an inhaled corticosteroid, suppressed the replication of MERS-...

A novel defective recombinant porcine enterovirus G virus carrying a porcine torovirus papain-like cysteine protease gene and a putative anti-apoptosis gene in place of viral structural protein genes.

Ryo Imai Makoto Nagai Mami Oba Shoichi Sakaguchi Makoto Ujike Ruka Kimura Moeko Kida Tsuneyuki Masuda Moegi Kuroda Rongduo Wen Kaixin Li Yukie Katayama Yuki Naoi Shinobu Tsuchiaka Tsutomu Omatsu Hiroshi Yamazato Shinji Makino Tetsuya Mizutani

Infection, genetics and evolution : journal of molecular epidemiology and evolutionary genetics in infectious diseases 75 103975-103975 2019年11月 [査読有り]

Enterovirus G (EV-G) belongs to the family of Picornaviridae. Two types of recombinant porcine EV-Gs carrying papain-like cysteine protease (PLCP) gene of porcine torovirus, a virus in Coronaviridae, are reported. Type 1 recombinant EV-Gs are dete...