Several drug-metabolizing cytochrome P450 (CYP) enzymes exhibit sexual dimorphism depending on the pituitary growth hormone (GH) secretory patterns. However, the mechanism underlying CYP sexual dimorphism remains unclear. We previously established...
Ryohei Ichimura Miwa Takahashi Tomomi Morikawa Kaoru Inoue Kazunori Kuwata Kento Usuda Makoto Yokosuka Gen Watanabe Midori Yoshida
Neurotoxicology 56 64-75 2016年9月 [査読有り]
Selective estrogen receptor modulators (SERMs) are a class of therapeutic chemicals which present tissue-specific estrogen receptor modulating activity. Neonatal exposure to SERMs has been reported to adversely affect central nervous system develo...
The Journal of veterinary medical science 78(5) 769-74 2016年6月 [査読有り]
In general, the nasal cavity of turtles is divided into two chambers: the upper chamber, lined with the olfactory epithelium containing ciliated olfactory receptor cells, and the lower chamber, lined with the vomeronasal epithelium containing micr...
The Journal of veterinary medical science 78(2) 245-50 2016年2月 [査読有り]
In turtles, the epithelia lining the upper and lower chambers of the nasal cavity project axons to the ventral and dorsal parts of the olfactory bulbs, respectively. In a semi-aquatic soft-shelled turtle, Pelodiscus sinensis, more than 1,000 odora...
Ryohei Ichimura Miwa Takahashi Tomomi Morikawa Kaoru Inoue Kazunori Kuwata Kento Usuda Makoto Yokosuka Gen Watanabe Midori Yoshida
Biology of reproduction 93(2) 32-32 2015年8月 [査読有り]
Neonatal exposure to estrogens is known to cause delayed effects, a late-occurring adverse effect on adult female reproductive functions, such as early onset of age-matched abnormal estrous cycling. However, the critical period in which neonates a...
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