研究者業績
基本情報
研究分野
1経歴
1-
2023年8月 - 現在
受賞
2論文
23-
European heart journal. Digital health 7(2) ztag021 2026年3月AIMS: In percutaneous coronary intervention (PCI), a suboptimal choice of guiding catheter may compromise coaxial alignment and backup support, prolonging procedures and increasing radiation and contrast exposure. We assessed whether a computed tomography (CT)-driven, artificial intelligence (AI)-guided preprocedural simulation could improve procedural efficiency and safety. METHODS AND RESULTS: In a single-centre prospective registry with historical controls, 55 consecutive elective procedures performed with CT-based AI-assisted guiding-catheter selection were compared with 55 procedures performed without assistance. The primary endpoint was total procedure time from arterial access to completion. Secondary endpoints included time to coronary engagement, radiation dose, contrast volume, and guiding-catheter-related events. Computed tomography--based AI assistance was associated with shorter procedures (mean 68.5 vs. 91.8 min), shorter engagement time, lower radiation dose, and lower contrast use. Guiding-catheter exchanges were fewer, and catheter-related events were lower (3.6 vs. 16.4%; risk ratio 0.22; 95% confidence interval 0.05-0.98). Procedural success was 100% in both groups with no in-hospital major adverse cardiac or cerebrovascular events. CONCLUSION: A CT-driven, CT-based AI-guided simulation for guiding-catheter selection was associated with greater procedural efficiency and a favourable profile in elective PCI. This approach, which standardizes catheter choice and is associated with fewer empirical catheter exchanges, warrants confirmation in multicentre randomized studies and may help optimize resource utilization in routine PCI.
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日本心血管インターベンション治療学会抄録集 33回 CC1-3 2025年7月
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日本心血管インターベンション治療学会抄録集 33回 MO38-3 2025年7月
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Catheterization and cardiovascular interventions : official journal of the Society for Cardiac Angiography & Interventions 106(1) 120-127 2025年7月We present a novel, simple, and low-cost "side-hole" technique for a patient with ST-segment elevation myocardial infarction (STEMI) caused by an occlusion of an anomalous origin of the culprit coronary artery (AOCCA). In a case where standard guiding catheters failed to engage the anomalous left coronary artery (LCA), we created an approximately 3 mm side-hole near the tip of a 5 Fr diagnostic catheter and then introduced a guidewire and microcatheter directly into the anomalous left main trunk (LMT). Subsequently, we withdrew this diagnostic catheter and exchanged it for a guiding catheter over the guide wire, enabling rapid primary PCI. This approach facilitated rapid wire passage, minimized additional device use, and helped reduce overall reperfusion time. It may be especially useful in urgent STEMI cases where a suitable guiding catheter for AOCCA lesions cannot be readily identified.
MISC
52-
日本不整脈心電学会カテーテルアブレーション関連大会(Web) 2025 2025年
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Japan Endovascular Treatment Conference (Web) 2025 2025年
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日本不整脈心電学会カテーテルアブレーション関連大会(Web) 2024 2024年
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Fujita medical journal 8(2) 65-66 2022年5月
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日本循環器学会学術集会(Web) 85th 2021年
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Fujita medical journal 7(1) 18-22 2021年OBJECTIVES: MicroRNAs (miRNA) are functional RNAs that have emerged as pivotal gene expression regulators in cardiac disease. Although several cardiomyocyte miRNAs have been reported to play roles in heart failure progression among patients with idiopathic dilated cardiomyopathy (DCM), the role of circulating miRNAs has not yet been well-examined. METHODS: After total RNA extraction from the peripheral blood samples of three control participants and six patients with DCM, miRNA profiling was performed using miRNA arrays. Based on the results of this initial screening, real-time polymerase chain reaction (RT-PCR) was used to perform a quantitative analysis of blood samples from a larger number of matched patients (DCM, n=20; controls, n=5). Finally, the correlations between specific miRNA expression levels and hemodynamic parameters were analyzed. RESULTS: A primary screening of 2,565 miRNAs resulted in the identification of nine miRNA candidates. Quantitative RT-PCR results revealed significantly increased miR-489 expression levels in the DCM group. Moreover, there was a significant positive correlation between miR-489 expression level and left ventricular ejection fraction. CONCLUSIONS: Our results suggest that circulating miR-489 could be a potential noninvasive diagnostic biomarker for DCM. Additionally, the quantification of circulating miR-489 may have value as a potential prognostic marker for patients with DCM.
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Fujita medical journal 7(3) 76-82 2021年OBJECTIVES: There are benefits of exercise-based cardiac rehabilitation (CR) in patients with heart failure (HF), but their underlying molecular mechanisms remain elusive. The effect of CR on the expression profile of circulating microRNAs (miRNAs), which are short noncoding RNAs that regulate posttranscriptional expression of target genes, is unknown. If miRNAs respond to changes following CR for HF, then serum profiling of miRNAs may reveal cardioprotective mechanisms of CR. METHODS: This study enrolled three hospitalized patients with progressed systolic HF and three normal volunteer controls. In patients, CR was initiated after improvement of HF, which included 2 weeks of bicycle ergometer and resistance exercises. Genome-wide expression profiling of circulating miRNAs was performed using microarrays for the patients (mean±SD age, 60.0±12.2 years) and controls (58.7±0.58 years). Circulating miRNA expression profiles were compared between patients with HF before and after CR and the controls. RESULTS: Expression levels of two miRNAs were significantly different in patients before CR compared with controls and patients after CR. The expression of hsa-miR-125b-1-3p was significantly downregulated and that of hsa-miR-1290 was significantly upregulated in patients before CR. CONCLUSIONS: When performing CR, expression of certain circulating miRNAs in patients with HF is restored to nonpathological levels. The benefits of CR for HF may result from regulation of miRNAs through multiple effects of gene expression.
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Journal of cardiology 72(6) 452-457 2018年12月
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Heart and vessels 32(3) 279-286 2017年3月
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Drug and chemical toxicology 40(1) 110-114 2017年1月
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Heart and vessels 31(6) 957-62 2016年6月
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Internal medicine (Tokyo, Japan) 55(3) 323-323 2016年
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心臓 47(10) 1213-1218 2015年<p> ビタミンB1欠乏症, 特に衝心脚気は現代では非常に稀な病態であるが, 1990年代から食生活の変化に伴い若年者に加え, 高齢者の症例も散見されるようになった.</p><p> 症例は意識障害にて救急搬送された中年男性で, 胸水・腹水含め, 全身性の著明な浮腫を伴っていた. 心臓超音波検査では重度のび漫性左室収縮低下を認めたが, 生活歴・食事歴よりビタミン欠乏を疑い, ビタミン補充治療を施行するも改善に乏しかった. ビタミン利用障害の可能性も考慮し, 大量補充療法を施行したところ, 速やかな意識状態の正常化を認め, 浮腫も改善した. 最終的には心機能も正常範囲に回復し, 社会生活への復帰が可能となった. 改善後, ビタミンB1負荷検査にて, ビタミンB1の利用障害が認められた.</p><p> 本症例のような偏食を伺わせる生活歴を持った原因不明の循環不全においては, 高拍出性心不全の病態でなくても, 脚気心の可能性を念頭に置く必要がある. 通常のビタミン補充療法で改善を認めない場合でも, ビタミンB1の利用障害が存在している可能性を考慮し, 典型的なWernicke脳症の症状を呈さなくても, 心不全に意識障害を併発している場合には, 早期から高用量のビタミンB1投与も検討する必要があると考えられた.</p>
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Internal medicine (Tokyo, Japan) 54(1) 31-5 2015年
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International heart journal 56(4) 415-20 2015年
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心臓 46(9) 1223-1230 2014年目的 : サルコイドーシスは一般的には自然寛解する予後良好な疾患と考えられているが, 心病変は本症による死亡原因の1位であり, 特に早期の心病変にはステロイドの有効性が認められているため的確な診断が必要とされる. 18F-FDG PETはその診断能が注目されており, 89%の症例で心臓サルコイドーシスが診断可能であったという報告もある. われわれはサルコイドーシスと診断した症例に対し18F-FDG PET/CTを用い心臓サルコイドーシスの検出を試み, さらに201Tl心筋血流シンチグラフィと比較し, 18F-FDG PET/CTの心臓サルコイドーシスの診断における有用性を検討した. 方法 : サルコイドーシスと診断された患者のうち, 18F-FDG PET/CTを施行した7症例につき検討した. 結果・考察 : 診断基準にて心臓サルコイドーシスと診断された3例において18F-FDGの集積が心臓に認められた. 心臓サルコイドーシスではないと判定された残り4例には心臓に集積は認めなかった. 201Tl心筋血流シンチグラフィと比較してもより鋭敏に病変をとらえることができた. 結論 : 18F-FDG PET/CTは疾患特異性が高く, 鋭敏に炎症像もとらえることができることから, 心臓サルコイドーシスの早期診断に有用であると考えられた.
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Journal of cardiology 61(5) 365-71 2013年5月
講演・口頭発表等
9-
第19回日本心血管インターベンション治療学会 2010年