Curriculum Vitaes
Profile Information
Research Areas
1Research History
1-
Aug, 2023 - Present
Awards
2Papers
23-
European heart journal. Digital health, 7(2) ztag021, Mar, 2026AIMS: In percutaneous coronary intervention (PCI), a suboptimal choice of guiding catheter may compromise coaxial alignment and backup support, prolonging procedures and increasing radiation and contrast exposure. We assessed whether a computed tomography (CT)-driven, artificial intelligence (AI)-guided preprocedural simulation could improve procedural efficiency and safety. METHODS AND RESULTS: In a single-centre prospective registry with historical controls, 55 consecutive elective procedures performed with CT-based AI-assisted guiding-catheter selection were compared with 55 procedures performed without assistance. The primary endpoint was total procedure time from arterial access to completion. Secondary endpoints included time to coronary engagement, radiation dose, contrast volume, and guiding-catheter-related events. Computed tomography--based AI assistance was associated with shorter procedures (mean 68.5 vs. 91.8 min), shorter engagement time, lower radiation dose, and lower contrast use. Guiding-catheter exchanges were fewer, and catheter-related events were lower (3.6 vs. 16.4%; risk ratio 0.22; 95% confidence interval 0.05-0.98). Procedural success was 100% in both groups with no in-hospital major adverse cardiac or cerebrovascular events. CONCLUSION: A CT-driven, CT-based AI-guided simulation for guiding-catheter selection was associated with greater procedural efficiency and a favourable profile in elective PCI. This approach, which standardizes catheter choice and is associated with fewer empirical catheter exchanges, warrants confirmation in multicentre randomized studies and may help optimize resource utilization in routine PCI.
-
日本心血管インターベンション治療学会抄録集, 33回 CC1-3, Jul, 2025
-
日本心血管インターベンション治療学会抄録集, 33回 MO38-3, Jul, 2025
-
日本心血管インターベンション治療学会抄録集, 33回 MP68-1, Jul, 2025
-
Catheterization and cardiovascular interventions : official journal of the Society for Cardiac Angiography & Interventions, 106(1) 120-127, Jul, 2025We present a novel, simple, and low-cost "side-hole" technique for a patient with ST-segment elevation myocardial infarction (STEMI) caused by an occlusion of an anomalous origin of the culprit coronary artery (AOCCA). In a case where standard guiding catheters failed to engage the anomalous left coronary artery (LCA), we created an approximately 3 mm side-hole near the tip of a 5 Fr diagnostic catheter and then introduced a guidewire and microcatheter directly into the anomalous left main trunk (LMT). Subsequently, we withdrew this diagnostic catheter and exchanged it for a guiding catheter over the guide wire, enabling rapid primary PCI. This approach facilitated rapid wire passage, minimized additional device use, and helped reduce overall reperfusion time. It may be especially useful in urgent STEMI cases where a suitable guiding catheter for AOCCA lesions cannot be readily identified.
Misc.
52-
日本不整脈心電学会カテーテルアブレーション関連大会(Web), 2025, 2025
-
日本循環器学会学術集会(Web), 89th, 2025
-
Japan Endovascular Treatment Conference (Web), 2025, 2025
-
日本不整脈心電学会カテーテルアブレーション関連大会(Web), 2024, 2024
-
日本不整脈心電学会カテーテルアブレーション関連大会(Web), 2024, 2024
-
Fujita medical journal, 8(2) 65-66, May, 2022
-
Fujita medical journal, 7(1) 18-22, 2021OBJECTIVES: MicroRNAs (miRNA) are functional RNAs that have emerged as pivotal gene expression regulators in cardiac disease. Although several cardiomyocyte miRNAs have been reported to play roles in heart failure progression among patients with idiopathic dilated cardiomyopathy (DCM), the role of circulating miRNAs has not yet been well-examined. METHODS: After total RNA extraction from the peripheral blood samples of three control participants and six patients with DCM, miRNA profiling was performed using miRNA arrays. Based on the results of this initial screening, real-time polymerase chain reaction (RT-PCR) was used to perform a quantitative analysis of blood samples from a larger number of matched patients (DCM, n=20; controls, n=5). Finally, the correlations between specific miRNA expression levels and hemodynamic parameters were analyzed. RESULTS: A primary screening of 2,565 miRNAs resulted in the identification of nine miRNA candidates. Quantitative RT-PCR results revealed significantly increased miR-489 expression levels in the DCM group. Moreover, there was a significant positive correlation between miR-489 expression level and left ventricular ejection fraction. CONCLUSIONS: Our results suggest that circulating miR-489 could be a potential noninvasive diagnostic biomarker for DCM. Additionally, the quantification of circulating miR-489 may have value as a potential prognostic marker for patients with DCM.
-
Fujita medical journal, 7(3) 76-82, 2021OBJECTIVES: There are benefits of exercise-based cardiac rehabilitation (CR) in patients with heart failure (HF), but their underlying molecular mechanisms remain elusive. The effect of CR on the expression profile of circulating microRNAs (miRNAs), which are short noncoding RNAs that regulate posttranscriptional expression of target genes, is unknown. If miRNAs respond to changes following CR for HF, then serum profiling of miRNAs may reveal cardioprotective mechanisms of CR. METHODS: This study enrolled three hospitalized patients with progressed systolic HF and three normal volunteer controls. In patients, CR was initiated after improvement of HF, which included 2 weeks of bicycle ergometer and resistance exercises. Genome-wide expression profiling of circulating miRNAs was performed using microarrays for the patients (mean±SD age, 60.0±12.2 years) and controls (58.7±0.58 years). Circulating miRNA expression profiles were compared between patients with HF before and after CR and the controls. RESULTS: Expression levels of two miRNAs were significantly different in patients before CR compared with controls and patients after CR. The expression of hsa-miR-125b-1-3p was significantly downregulated and that of hsa-miR-1290 was significantly upregulated in patients before CR. CONCLUSIONS: When performing CR, expression of certain circulating miRNAs in patients with HF is restored to nonpathological levels. The benefits of CR for HF may result from regulation of miRNAs through multiple effects of gene expression.
-
Journal of cardiology, 72(6) 452-457, Dec, 2018
-
Heart and vessels, 32(3) 279-286, Mar, 2017
-
Drug and chemical toxicology, 40(1) 110-114, Jan, 2017
-
Heart and vessels, 31(6) 957-62, Jun, 2016
-
Internal medicine (Tokyo, Japan), 55(3) 323-323, 2016
-
Internal medicine (Tokyo, Japan), 54(1) 31-5, 2015
-
International heart journal, 56(4) 415-20, 2015
-
Journal of cardiology, 61(5) 365-71, May, 2013
Presentations
9-
第19回日本心血管インターベンション治療学会, 2010