医学部 乳腺外科
Profile Information
- Affiliation
- Associate Professor, Department of Respiratory Medicine, Fujita Health University School of Medicine
- Degree
- Doctor of Philosophy(Medical Science)(Jan, 2010, Nagoya University)
- Contact information
- gotoyasu
fujita-hu.ac.jp - J-GLOBAL ID
- 201501020248290142
- researchmap Member ID
- 7000012732
Research Areas
1Research History
9-
Jul, 2018 - Jul, 2025
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Apr, 2014 - Jun, 2018
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Jun, 2009 - Mar, 2014
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Apr, 2008 - May, 2009
Education
2-
Apr, 2004 - Mar, 2008
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Apr, 1993 - Mar, 1999
Committee Memberships
5-
Apr, 2022 - Present
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Apr, 2022 - Present
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Mar, 2019 - Present
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Apr, 2018 - Present
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Apr, 2019 - Mar, 2022
Major Papers
248-
Nature genetics, 57(1) 65-79, Jan, 2025
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BMC pulmonary medicine, 24(1) 632-632, Dec 26, 2024
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Clinical cancer research : an official journal of the American Association for Cancer Research, 31(6) 1127-1141, Nov 4, 2024
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Cancer research and treatment, 57(2) 412-421, Oct 25, 2024
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Japanese journal of clinical oncology, 54(10) 1084-1092, Aug 19, 2024
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Targeted oncology, 19(3) 423-433, May, 2024
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日本呼吸器学会誌, 13(増刊) 190-190, Mar, 2024
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Respiration; international review of thoracic diseases, 103(4) 171-176, Feb 22, 2024
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Exploration of targeted anti-tumor therapy, 5(4) 826-840, 2024Despite innovative advances in molecular targeted therapy, treatment strategies using immune checkpoint inhibitors (ICIs) for epidermal growth factor receptor (EGFR)-mutant non-small cell lung cancer (NSCLC) have not progressed significantly. Accumulating evidence suggests that ICI chemotherapy is inadequate in this population. Biomarkers of ICI therapy, such as programmed cell death ligand 1 (PD-L1) and tumor-infiltrating lymphocytes (TILs), are not biomarkers in patients with EGFR mutations, and the specificity of the tumor microenvironment has been suggested as the reason for this. Combination therapy with PD-L1 and cytotoxic T-lymphocyte-associated protein 4 (CTLA-4) inhibitors is a concern because of its severe toxicity and limited efficacy. However, early-stage NSCLC may differ from advanced-stage NSCLC. In this review, we comprehensively review the current evidence and summarize the potential of ICI therapy in patients with EGFR mutations after acquiring resistance to treatment with EGFR-tyrosine kinase inhibitors (TKIs) with no T790M mutation or whose disease has progressed on osimertinib.
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Frontiers in immunology, 15 1348034-1348034, 2024
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Frontiers in immunology, 15 1399889-1399889, 2024
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Therapeutic advances in respiratory disease, 18 17534666241254980-17534666241254980, 2024
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Targeted oncology, 18(6) 915-925, Oct 30, 2023
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European journal of cancer (Oxford, England : 1990), 195 113373-113373, Oct 22, 2023 Peer-reviewed
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肺癌, 63(5) 427-427, Oct, 2023
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Targeted Oncology, 18(5) 657-665, Aug 23, 2023
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JAMA network open, 6(7) e2322915, Jul 3, 2023 Peer-reviewed
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Cancer medicine, 12(15) 15955-15969, Jun 23, 2023
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気管支学, 45(Suppl.) S237-S237, Jun, 2023
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Thorax, 78(8) 784-791, Apr 3, 2023 Peer-reviewed
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日本呼吸器学会誌, 12(増刊) 165-165, Mar, 2023
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日本呼吸器学会誌, 12(増刊) 206-206, Mar, 2023
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日本呼吸器学会誌, 12(増刊) 168-168, Mar, 2023
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Cancer science, 114(2) 606-618, Feb, 2023
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Cancer immunology, immunotherapy : CII, 72(6) 1699-1707, Jan 9, 2023
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The oncologist, 27(11) 903-e834-E834, Nov 3, 2022
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Clinical lung cancer, 23(7) 585-592, Nov, 2022
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JTO clinical and research reports, 3(9) 100388-100388, Sep, 2022
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Translational lung cancer research, 11(9) 1847-1857, Sep, 2022
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Clinical cancer research : an official journal of the American Association for Cancer Research, 28(20) 4402-4409, Aug 18, 2022
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Fujita medical journal, 8(1) 17-24, Feb, 2022OBJECTIVE: The prevalence of obstructive sleep apnea (OSA) in Japan is 9% among males and 3% among females. Up to 2.5 million patients are estimated to suffer from the disease, but limited number of facilities are capable of carrying out polysomnography (PSG), leaving more than 80% of these individuals are undiagnosed. In recent years, the development of new portable sleep monitoring (PMs) devices has been remarkable. We evaluate the correlation between the results of the LS-140 PMs device (Fukuda Denshi Tech Co. Ltd.), released in 2017, and those of PSG. METHODS: We obtained contemporaneous data from the same patients by equipping 58 patients with PMs (LS-140) devices while they underwent PSG. Our primary outcome was Case 2 of the intraclass correlation coefficient (ICC), i.e., the ICC (2.1). And we used a Bland-Altman analysis to compare the apnea-hypopnea index (AHI) given by PSG and the respiratory event index (REI) given by LS-140 and examined the sensitivity and specificity of the REI relative to the AHI in the diagnosis of OSA. We also carried out the same comparison but in terms of the presence or absence of periodic limb movements (PLMs). RESULTS: The ICC (2.1) between The REI and the AHI was 0.944, a rather high value (p<0.0001). The mean difference between AHI and REI values was -3.6 (p<0.0001), indicating a negative fixed bias. Sensitivity may decrease in groups with PLMs. CONCLUSION: The REI and the AHI are highly correlated, giving LS-140 sufficient diagnostic sensitivity and specificity to screen for OSA.
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Journal of cancer research and clinical oncology, 148(11) 2985-2994, Nov 26, 2021
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Journal of cancer research and clinical oncology, 148(9) 2437-2446, Sep 12, 2021
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Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer, 16(9) 1523-1532, Sep, 2021
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Biological & pharmaceutical bulletin, 44(9) 1280-1285, Sep 1, 2021
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Lung cancer (Amsterdam, Netherlands), 161 26-33, Aug 31, 2021
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TRANSLATIONAL LUNG CANCER RESEARCH, 10(8) 3582-3593, Aug, 2021
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Allergology international : official journal of the Japanese Society of Allergology, 70(3) 401-403, Jul, 2021
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BMC pulmonary medicine, 21(1) 181-181, May 29, 2021
Misc.
484Books and Other Publications
4Presentations
457Professional Memberships
13Research Projects
1-
医学研究・健康増進活動等助成, 一般財団法人 愛知健康増進財団, Apr, 2020 - Mar, 2021
教育方法・教育実践に関する発表、講演等
2-
件名(英語)第一回研修医のための呼吸器セミナー開始年月日(英語)2018/02/03終了年月日(英語)2018/02/03概要(英語)東海4県の医学系大学が集まり、初期研修医向けの呼吸器セミナーを開催
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件名(英語)第二回研修医のための呼吸器セミナー(主幹)開始年月日(英語)2019/02/02終了年月日(英語)2019/02/02概要(英語)呼吸器学会東海支部主催で初期研修医向けの呼吸器セミナーを開催(当大学が主幹で主催した)