研究者業績
基本情報
研究分野
1論文
76-
Journal of cardiology cases 32(4) 183-186 2025年10月UNLABELLED: As an alternative to implantable cardioverter defibrillators, the wearable cardioverter defibrillator (WCD; LifeVest®, Asahi KASEI Zoll Medical Co., Tokyo, Japan) is the only noninvasive cardioverter defibrillator available that can be worn directly on the skin. The first consensus statement on WCD use in Japan was published in 2014, and, similar to guidelines in other countries, its recommendations focus on adult patients. Pediatric cases involving WCD remain limited, and appropriate indications for its use in children are yet to be established. Here, we report the first pediatric case in Japan where WCD monitored a patient and delivered an appropriate shock to terminate a life-threatening ventricular tachycardia and ventricular fibrillation episode. During this time, the patient was recovering from takotsubo cardiomyopathy, presumably associated with refeeding syndrome secondary to Crohn's disease. No inappropriate shocks were delivered during the three-month monitoring period, and the WCD use was deemed safe. The continuous monitoring function of WCD aided in understanding the patient's conditions. Following treatment, the patient has recovered from Crohn's disease and his cardiac function has stabilized, and he has not experienced neurological sequelae or heart failure symptoms since. This case highlights the potential of WCD use in pediatric patients. LEARNING OBJECTIVE: The wearable cardioverter defibrillator (WCD; LifeVest®) is the only noninvasive cardioverter defibrillator available. However, current guidelines around the world primarily focus on adult patients. Cases of pediatric patients who are rescued by an appropriate shock by WCD are still limited and many aspects, such as device set-up, effectiveness, and risks require further study. This case supports that WCD in children can be safe and effective, demonstrating its potential to protect against ventricular tachycardia and ventricular fibrillation and prevent sudden cardiac death.
MISC
235-
CLINICAL AND EXPERIMENTAL RHEUMATOLOGY 28(4) 558-560 2010年7月 査読有り
-
MODERN RHEUMATOLOGY 20(2) 193-195 2010年4月 査読有り
-
Pediatr Int 38(9) 149-506 2009年 査読有り
-
アレルギー 56(8-9) 1058-1058 2007年9月
-
アレルギー 56(3-4) 396-396 2007年4月
-
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY 119(1) S193-S193 2007年1月
-
Allergol Int 56(2) 149-155 2007年Background: Phenytoin can induce diversified adverse reactions including generalized eruptions and the hypersensitivity syndrome. Delayed-type allergic mechanisms have been postulated to underlie these reactions. The tests most widely used to detect T-cell sensitization to drugs are the patch test and the lymphocyte transformation test (LTT), but their sensitivity is not sufficient. Simultaneous assessment of both the frequencies and the cytokine-producing phenotypes of allergen-specific T cells has become possible with the recently introduced carboxyfluorescein succinimidyl ester (CFSE) assay.<br> Methods: Seven patients who presented with phenytoin-induced maculopapular exanthema with and without fever were included in this study. Peripheral blood mononuclear cells (PBMCs) were labeled with CFSE and cultured with phenytoin for seven days. The cells were stained with anti-CD4 and cytokine-specific monoclonal antibodies (MoAbs), and analyzed with FACSCalibur.<br> Results: The phenytoin-specific proliferation of CD4+ cells in patients was significantly higher than in the four controls exposed to phenytoin, and in seven healthy children with no previous phenytoin intake. A significant difference in the percentages of CD4+ IFN-γ+ cells between patients and the seven healthy children was observed. The sensitivity and specificity of proliferation were 100% and 90.9%, and those of IFN-γ secretion were 71.4% and 100%, respectively.<br> Conclusions: Phenytoin-specific proliferation may be detected with greater sensitivity by the CFSE dilution assay than the conventional LTT. The assay revealed that both CD4+ and CD4- T cells proliferated and produced IFN-γ and TNF-α after stimulation with phenytoin. The CFSE dilution assay might be useful for the diagnosis and understanding of drug hypersensitivity.<br>
-
日本ラテックスアレルギー研究会会誌 10(1) 97-101 2006年12月スギ花粉症とキウイあるいはメロンアレルギーをもつ患者の血清を用い、ELISA inhibitionによってスギ花粉抗原と果物抗原の交差反応部分をIgEが認識しているかどうかを検討した。スギ花粉症と果物アレルギーを合併している9例を対象とした。果物アレルギーの主な症状は口腔アレルギー症状であった。原因果物として多かったのはメロン(7例)とキウイ(6例)であった。これらの血清で、スギ花粉により果物抗原に対するIgE結合能が抑制されるパターとスギ花粉抗原により果物抗原に対するIgE結合能が抑制されないパターンがえられた。交差部位を認識するIgEを持った患者血清を用いてinhibition immunoblotによる検討を行った。メロン抗原とキウイ抗原、いずれの抗原も低分子量タンパク質バンドに対する患者のIgE結合能がスギ抗原の添加により消失している像が見られた。
書籍等出版物
1講演・口頭発表等
8共同研究・競争的資金等の研究課題
2-
日本学術振興会 科学研究費助成事業 2020年4月 - 2025年3月
-
日本学術振興会 科学研究費助成事業 2021年4月 - 2024年3月