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  2. murayama kazuhiro

murayama kazuhiro

  (村山 和宏)

Profile Information

Affiliation
Fujita Health University
Degree
博士(医学）(Mar, 2009, 藤田医科大学)
J-GLOBAL ID
201501003183664994
researchmap Member ID
7000012853

Research Interests

 3

Research Areas

 1

Research History

 1

Education

 1

Committee Memberships

 1

Awards

 3

Papers

 103
  • Eiji Fujiwara, Jun Muto, Kazuhiro Murayama, Seiji Yamada, Yuichi Hirose
    Operative Neurosurgery, Dec 3, 2024  
    BACKGROUND AND IMPORTANCE: The usefulness of intraoperative real-time fluorescence navigation using indocyanine green (ICG) for metastatic brain tumors, schwannomas, and meningiomas is well established. However, its application in cases of radiation-induced brain necrosis remains unexplored. Surgical intervention is performed in symptomatic and medically refractory cases; however, radiation-necrotic lesions often exhibit a diffuse pattern with unclear surgical boundaries, making it challenging for surgeons to identify the lesion during the surgery. METHODS: Four patients with intracranial necrotic tissues received 1.5 mg/kg ICG 1 hour before observation during the surgery. We used near-infrared fluorescence to identify the necrotic location. CLINICAL PRESENTATION: Case 1: A 61-year-old man with lung cancer and metastatic brain tumor history exhibited left-sided weakness a year after craniotomy and radiotherapy. A new lesion required surgery, where ICG fluorescence imaging highlighted a significant contrast in the resection cavity, aiding in successful lesion removal without complications. Case 2: A 51-year-old man with resected glioblastoma developed paralysis. ICG fluorescence during surgery confirmed necrosis and enabled the lesion's removal despite potential inaccuracies due to brain shift, without ICG-related complications. Near-infrared fluorescence could visualize necrotic tissues in all 4 cases. The mean signal-to-background ratio of the necrotic tissues in delayed window ICG was 3.5 ± 0.7. The ratio of the gadolinium-enhanced T1 tumor signal to the brain (T1-weighted background ratio) was 2.3 ± 0.4. CONCLUSION: This report is the first to demonstrate the efficacy of ICG intraoperative fluorescence imaging in identifying radiation-induced necrotic brain tissues.
  • Hirotaka Ikeda, Yoshiharu Ohno, Kaori Yamamoto, Kazuhiro Murayama, Masato Ikedo, Masao Yui, Yunosuke Kumazawa, Yurika Shimamura, Yui Takagi, Yuhei Nakagaki, Satomu Hanamatsu, Yuki Obama, Takahiro Ueda, Hiroyuki Nagata, Yoshiyuki Ozawa, Akiyoshi Iwase, Hiroshi Toyama
    Cancers, 16(9), Apr 28, 2024  
    BACKGROUND: Diffusion-weighted images (DWI) obtained by echo-planar imaging (EPI) are frequently degraded by susceptibility artifacts. It has been suggested that DWI obtained by fast advanced spin-echo (FASE) or reconstructed with deep learning reconstruction (DLR) could be useful for image quality improvements. The purpose of this investigation using in vitro and in vivo studies was to determine the influence of sequence difference and of DLR for DWI on image quality, apparent diffusion coefficient (ADC) evaluation, and differentiation of malignant from benign head and neck tumors. METHODS: For the in vitro study, a DWI phantom was scanned by FASE and EPI sequences and reconstructed with and without DLR. Each ADC within the phantom for each DWI was then assessed and correlated for each measured ADC and standard value by Spearman's rank correlation analysis. For the in vivo study, DWIs obtained by EPI and FASE sequences were also obtained for head and neck tumor patients. Signal-to-noise ratio (SNR) and ADC were then determined based on ROI measurements, while SNR of tumors and ADC were compared between all DWI data sets by means of Tukey's Honest Significant Difference test. RESULTS: For the in vitro study, all correlations between measured ADC and standard reference were significant and excellent (0.92 ≤ ρ ≤ 0.99, p < 0.0001). For the in vivo study, the SNR of FASE with DLR was significantly higher than that of FASE without DLR (p = 0.02), while ADC values for benign and malignant tumors showed significant differences between each sequence with and without DLR (p < 0.05). CONCLUSION: In comparison with EPI sequence, FASE sequence and DLR can improve image quality and distortion of DWIs without significantly influencing ADC measurements or differentiation capability of malignant from benign head and neck tumors.
  • Jun Muto, Yutaka Mine, Yuya Nishiyama, Kazuhiro Murayama, Motoharu Hayakawa, Mitsuhiro Hasegawa, John K.Y. Lee, Yuichi Hirose
    World Neurosurgery, Mar, 2023  
  • Shunsuke Nakae, Masanobu Kumon, Akio Katagata, Kazuhiro Murayama, Yuichi Hirose
    Brain Sciences, 13(3) 396-396, Feb 25, 2023  
    Vagus nerve stimulation (VNS) is an effective surgical option for intractable epilepsy. Although the surgical procedure is not so complicated, vagus nerve detection is sometimes difficult due to its anatomical variations, which may lead to surgical manipulation-associated complications. Thus, this study aimed to visualize the vagus nerve location preoperatively by fused images of three-dimensional computed tomography angiography (3D-CTA) and magnetic resonance imaging (MRI). This technique was applied to two cases. The neck 3D-CTA and MRI were performed, and the fused images were generated using the software. The vagus nerve and its anatomical relationship with the internal jugular vein (IJV) and common carotid artery were clearly visualized. The authors predicted that the vagus nerve was detected by laterally pulling the IJV according to the images. Intraoperatively, the vagus nerve was located as the authors predicted. The time of the surgery until the vagus nerve detection was &lt;60 min in both cases. This novel radiological technique for visualizing the vagus nerve is effective to quickly detect the vagus nerve, which has anatomical variations, during the VNS.
  • Kazuhiro Murayama, Yoshiharu Ohno, Masao Yui, Kaori Yamamoto, Masato Ikedo, Shigeo Ohba, Satomu Hanamatsu, Akiyoshi Iwase, Hirotaka Ikeda, Yuichi Hirose, Hiroshi Toyama
    Journal of computer assisted tomography, Feb 10, 2023  
    OBJECTIVE: Although amide proton transfer-weighted (APTw) imaging is reported by 2-dimensional (2D) spin-echo-based sequencing, 3-dimensional (3D) APTw imaging can be obtained by gradient-echo-based sequencing. The purpose of this study was to compare the efficacy of APTw imaging between 2D and 3D imaging in patients with various brain tumors. METHODS: A total of 49 patients who had undergone 53 examinations [5 low-grade gliomas (LGG), 16 high-grade gliomas (HGG), 6 malignant lymphomas, 4 metastases, and 22 meningiomas] underwent APTw imaging using 2D and 3D sequences. The magnetization transfer ratio asymmetry (MTRasym) was assessed by means of region of interest measurements. Pearson correlation was performed to determine the relationship between MTRasym for the 2 methods, and Student's t test to compare MTRasym for LGG and HGG. The diagnostic accuracy to differentiate HGG from LGG of the 2 methods was compared by means of the McNemar test. RESULTS: Three-dimensional APTw imaging showed a significant correlation with 2D APTw imaging (r = 0.79, P < 0.0001). The limits of agreement between the 2 methods were -0.021 ± 1.42%. The MTRasym of HGG (2D: 1.97 ± 0.96, 3D: 2.11 ± 0.95) was significantly higher than those of LGG (2D: 0.46 ± 0.89%, P < 0.01; 3D: 0.15 ± 1.09%, P < 0.001). The diagnostic performance of the 2 methods to differentiate HGG from LGG was not significantly different (P = 1). CONCLUSIONS: The potential capability of 3D APTw imaging is equal to or greater than that of 2D APTw imaging and is considered at least as valuable in patients with brain tumors.
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Misc.

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Professional Memberships

 4

Research Projects

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教育方法・教育実践に関する発表、講演等

 2
  • 件名（英語）
    第36回日本脳神経CI学会 ランチョンセミナー
    終了年月日（英語）
    2013/02/23
  • 件名（英語）
    院内ISLS
    終了年月日（英語）
    2013/03/05
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