Shosuke Ito

(伊藤祥輔)

Profile Information

Affiliation: Professor, Institute for Melanin Chemistry, Fujita Health University

Degree: Doctor of Science, Doctor of Medicine
医学博士

J-GLOBAL ID: 200901053326272218
researchmap Member ID: 1000102729

Research Interests

Research Areas

Education

- 1972

Nagoya University
- 1972

Graduate School, Division of Natural Science, Nagoya University
- 1967

School of Science, Osaka University
- 1967

Faculty of Science, Osaka University

Committee Memberships

Awards

Papers

250

A Cell-Based Evaluation of the Tyrosinase-Mediated Metabolic Activation of Leukoderma-Inducing Phenols, II: The Depletion of Nrf2 Augments the Cytotoxic Effect Evoked by Tyrosinase in Melanogenic Cells

Tomoko Nishimaki-Mogami, Shosuke Ito, Kazumasa Wakamatsu, Takumi Akiyama, Norimasa Tamehiro, Norihito Shibata

Biomolecules, Jan 13, 2025
メラノジェネシス標的低分子NPrCAPとナノマグネタイト粒子結合による次世代型低侵襲性メラノーマ化学・温熱・免疫療法(CTI療法)の産学共同開発

神保孝一, 肥田時征, 川上聡経, 伊藤祥輔, 若松一雅, 井藤彰, 本多裕之, 田村保明, 鳥越俊彦

日本皮膚科学会雑誌, 134(12) 3017-3034, Nov, 2024
Pterostilbene, a Dimethyl Derivative of Resveratrol, Exerts Cytotoxic Effects on Melanin-Producing Cells through Metabolic Activation by Tyrosinase

Hitomi Tanaka, Tomoko Nishimaki-Mogami, Norimasa Tamehiro, Norihito Shibata, Hiroki Mandai, Shosuke Ito, Kazumasa Wakamatsu

International Journal of Molecular Sciences, Sep 17, 2024
Sperm Size Decreases With Increasing Pheomelanin Pigmentation but Not With the Amount of Glutathione in the Barn Swallow

Masaru Hasegawa, Emi Arai, Hitomi Tanaka, Shosuke Ito, Kazumasa Wakamatsu

Zoological Science, 41(5), Jul 11, 2024
Genetic insights into Tietz albinism‐deafness syndrome: A new dominant‐negative mutation in MITF

Kohei Yamamoto, Ken Okamura, Kazumasa Wakamatsu, Shosuke Ito, Kozue Akabane, Yosuke Arai, Junnosuke Kawaguchi, Yutaka Hozumi, Tamio Suzuki

Pigment Cell & Melanoma Research, Jul, 2024

Misc.

210

Melanin biology and translational research strategy; melanogenesis and nanomedicine as the basis for melanoma-targeted DDS and chemothermoimmunotherapy

K. Jimbow, T. Takada, M. Sato, A. Sato, T. Kamiya, I. Ono, T. Yamashita, Y. Tamura, S. Sato, A. Miyamoto, A. Ito, H. Honda, K. Wakamatsu, S. Ito

PIGMENT CELL & MELANOMA RESEARCH, 21(2) 243-244, Apr, 2008
Characterization of melanin in human iridal and choroidal melanocytes from eyes with various colored irides

Kazumasa Wakamatsu, Dan-Ning Hu, Steven A. McCormick, Shosuke Ito

PIGMENT CELL & MELANOMA RESEARCH, 21(1) 97-105, Feb, 2008
NPrCAP/マグネタイトの新規標的DDSの開発とメラノーマ化学・温熱・免疫(CTI)療法

高田知明, 山下利春, 小野一郎, 酒本亜紀子, 佐藤牧人, 神保孝一, 佐藤昇志, 田村保明, 本多裕之, 井藤彰, 伊藤祥輔, 若松一雅

日本皮膚科学会雑誌, 118(1) 65, Jan 20, 2008
メラノーマ標的ナノパーティクルNPrCAP/Mを用いた化学温熱免疫療法における腫瘍免疫機構の解析

佐藤亜紀子, 田村保明, 佐藤昇志, 山下和春, 高田知明, 佐藤牧人, 井藤彰, 本多裕之, 若松一雅, 伊藤祥輔, 神保孝一

Therm Med, 24(Supplement) 99, 2008
Pael receptor is involved in dopamine metabolism in the nigrostriatal system

Yuzuru Imai, Haruhisa Inoue, Ayane Kataoka, Wang Hua-Qin, Masao Masuda, Toshio Ikeda, Kayoko Tsukita, Mariiko Soda, Tohru Kodama, Tatsu Fuwa, Yoshiko Honda, Satoshi Kaneko, Sadayuki Matsumoto, Kazumasa Wakamatsu, Shosuke Ito, Masami Miura, Toshihiko Aosaki, Shigeyoshi Itohara, Ryosuke Takahashi

NEUROSCIENCE RESEARCH, 59(4) 413-425, Dec, 2007
Analysis of a new coat color mutant mouse strain along with aging

Yasunari Sato, Ryutaro Ishida, Eriko Inada, Shigekazu Tanaka, Masaru Tamura, Hiroshi Masltya, Shigeharu Wakana, Toshihiko Shiroishi, Kazumasa Wakamatsu, Shosuke Ito, Hiroaki Yamamoto

GENES & GENETIC SYSTEMS, 82(6) 533-533, Dec, 2007
Childhood malnutrition is associated with a reduction in the total melanin content of scalp hair

Colin A. McKenzie, Kazumasa Wakamatsu, Neil A. Hanchard, Terrence Forrester, Shosuke Ito

BRITISH JOURNAL OF NUTRITION, 98(1) 159-164, Jul, 2007
High levels of melanin-related metabolites in plasma from pink-eyed dilution mice

Kazumasa Wakamatsu, Tomohisa Hirobe, Shosuke Ito

PIGMENT CELL RESEARCH, 20(3) 222-224, Jun, 2007
メラノーマ標的ナノ微粒子(NPrCAP/ML)によるメラノーマ温熱免疫療法の開発

神保孝一, 山下利春, 小野一郎, 松坂英信, 高田知明, 佐藤牧人, 酒本亜紀子, 佐藤昇志, 田村保明, 宮本篤, 本多裕之, 伊藤祥輔, 若松一雅, 井藤彰

新しい医療機器研究, 12 39-40, Mar 25, 2007
4-S-Cysteaminylphenol-loaded magnetite cationic liposomes for combination therapy of hyperthermia with chemotherapy against malignant melanoma

Akira Ito, Masatake Fujioka, Tatsuro Yoshida, Kazumasa Wakamatsu, Shosuke Ito, Toshiharu Yamashita, Kowichi Jimbow, Hiroyuki Honda

CANCER SCIENCE, 98(3) 424-430, Mar, 2007
Serum levels of pigmentation markers are elevated in patients undergoing hemodialysis

Kazutaka Murakami, Kazumasa Wakamatsu, Yukiko Nakanishi, Hiroki Takahashi, Satoshi Sugiyama, Shosuke Ito

BLOOD PURIFICATION, 25(5-6) 483-489, 2007
Mid-infrared absorption spectrum of 5,6-dihydroxyindole-2-carboxylic acid

Hidekazu Okuda, Atsushi Nakamura, Kazumasa Wakamatsu, Shosuke Ito, Takayuki Sota

CHEMICAL PHYSICS LETTERS, 433(4-6) 355-359, Jan, 2007
Pael receptor induces death of dopaminergic neurons in the substantia nigra via endoplasmic reticulum stress and dopamine toxicity, which is enhanced under condition of parkin inactivation

Yasuko Kitao, Yuzuru Imai, Kentaro Ozawa, Ayane Kataoka, Toshio Ikeda, Mariko Soda, Kazuhiko Nakimawa, Hiroshi Kiyama, David M. Stern, Osamu Hori, Kazumasa Wakamatsu, Shosuke Ito, Shigeyoshi Itohara, Ryosuke Takahashi, Satoshi Ogawa

HUMAN MOLECULAR GENETICS, 16(1) 50-60, Jan, 2007
Evaluation of melanin-related metabolites as markers of solar ultraviolet-B radiation

Kazumasa Wakamatsu, Shosuke Ito

PIGMENT CELL RESEARCH, 19(5) 460-464, Oct, 2006
Development of new target therapy in melanoma treatment: Melanoma chemistry, warm temperature, and immunotherapy by melarno-genesis target nano particles and tyrosine (phenol) inductor.

神保孝一, 山下利春, 小野一郎, 松坂英信, 高田知明, 佐藤牧人, 酒本亜紀子, 佐藤昇志, 田村保明, 宮本篤, 本多裕之, 井藤彰, 伊藤祥輔, 若松一雅

日本臨床皮膚科医会雑誌, 23(6) 524-530, Sep 15, 2006
Topical drug rescue strategy and skin protection based on the role of Mc1r in UV-induced tanning

John A. D'Orazio, Tetsuji Nobuhisa, Rutao Cui, Michelle Arya, Malinda Spry, Kazumasa Wakamatsu, Vivien Igras, Takahiro Kunisada, Scott R. Granter, Emi K. Nishimura, Shosuke Ito, David E. Fisher

NATURE, 443(7109) 340-344, Sep, 2006
マグネタイト結合型システアミニールフェノール(NPrCAP/M)のメラノーマ細胞親和性と細胞死誘導

佐藤牧人, 山下利春, 小野一郎, 田村保明, 佐藤昇志, 若松一雅, 伊藤祥輔, 井藤彰, 本多裕之, 神保孝一

日本癌学会学術総会記事, 65th 446, Aug 28, 2006
メラノーマ標的ナノパーティクルNPrCAP/Mを用いた化学温熱免疫(CTI)療法における腫瘍免疫機構の解析

酒本亜紀子, 田村保明, 佐藤昇志, 山下利春, 高田知明, 佐藤牧人, 小野一郎, 井藤彰, 本多裕之, 若松一雅, 伊藤祥輔, 神保孝一

日本癌学会学術総会記事, 65th 497, Aug 28, 2006
4‐S‐CAP包埋型MCLによる悪性黒色腫に対する温熱化学療法

吉田達郎, 藤岡正剛, 井藤彰, 若松一雅, 伊藤祥輔, 神保孝一, 本多裕之

日本生物工学会大会講演要旨集, 58th 202, Aug 3, 2006
Melanin content and MC1R function independently affect UVR-induced DNA damage in cultured human melanocytes

Jennifer E. Hauser, Ana Luisa Kadekaro, Renny J. Kavanagh, Kazumasa Wakamatsu, Silva Terzieva, Sandy Schwemberger, George Babcock, M. B. Rao, Shosuke Ito, Zalfa A. Abdel-Malek

PIGMENT CELL RESEARCH, 19(4) 303-314, Aug, 2006
Interaction of Hermansky-Pudlak syndrome genes in the regulation of lysosome-related organelles

Rashi Gautam, Edward K. Novak, Jian Tan, Kazumasa Wakamatsu, Shosuke Ito, Richard T. Swank

TRAFFIC, 7(7) 779-792, Jul, 2006
The slaty mutation affects eumelanin and pheomelanin synthesis in mouse melanocytes

T Hirobe, K Wakamatsu, S Ito, Y Kawa, Y Soma, M Mizoguchi

EUROPEAN JOURNAL OF CELL BIOLOGY, 85(6) 537-549, Jun, 2006
Determination of eumelanin in human urine

K Wakamatsu, A Takasaki, B Kagedal, T Kageshita, S Ito

PIGMENT CELL RESEARCH, 19(2) 163-169, Apr, 2006
Diversity of pigmentation in cultured human melanocytes is due to differences in the type as well as quantity of melanin

K Wakamatsu, R Kavanagh, AL Kadekaro, S Terzieva, RA Sturm, S Leachman, Z Abdel-Malek, S Ito

PIGMENT CELL RESEARCH, 19(2) 154-162, Apr, 2006
Highly sensitive detection of melanoma at an early stage based on the increased serum secreted protein acidic and rich in cysteine and glypican-3 levels.

Yoshiaki Ikuta, Tetsuya Nakatsura, Toshiro Kageshita, Satoshi Fukushima, Shosuke Ito, Kazumasa Wakamatsu, Hideo Baba, Yasuharu Nishimura

Clinical cancer research : an official journal of the American Association for Cancer Research, 11(22) 8079-88, Nov 15, 2005 Peer-reviewed
Mutations in dopachrome tautomerase (Dct) affect eumelanin/pheomelanin synthesis, but do not affect intracellular trafficking of the mutant protein

GE Costin, JC Valencia, K Wakamatsu, S Ito, F Solano, AL Milac, WD Vieira, Y Yamaguchi, F Rouzaud, AJ Petrescu, ML Lamoreux, VJ Hearing

BIOCHEMICAL JOURNAL, 391 249-259, Oct, 2005
Inactivation of Drosophila DJ-1 leads to impairments of oxidative stress response and phosphatidylinositol 3-kinase/Akt signaling

YF Yang, S Gehrke, ME Haque, Y Imai, J Kosek, LC Yang, MF Beal, Nishimura, I, K Wakarnatsu, S Ito, R Takahashi, BW Lu

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 102(38) 13670-13675, Sep, 2005
Common anti-apoptotic roles of parkin and alpha-synuclein in human dopaminergic cells (vol 332, pg 233, 2005)

Y Machida, T Chiba, A Takayanagi, Y Tanaka, M Asanuma, N Ogawa, A Koyama, T Iwatsubo, S Ito, PH Jansen, N Shimizu, K Tanaka, Y Mizuno, N Hattori

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 334(3) 970-970, Sep, 2005
A novel P gene mutation and the frequency of type 2 oculocutaneous albinism among Japanese albino patients

S Ito, T Suzuki, K Inagaki, N Suzuki, Y Tomita

JOURNAL OF INVESTIGATIVE DERMATOLOGY, 125(3) A24-A24, Sep, 2005
Three novel mutations in the membrane-associated transporter protein gene with oculocutaneous albinism type 4

K Inagaki, T Suzuki, S Ito, N Suzuki, Y Tomita

JOURNAL OF INVESTIGATIVE DERMATOLOGY, 125(3) A25-A25, Sep, 2005
Slc7a11 gene controls production of pheomelanin pigment and proliferation of cultured cells

S Chintala, W Li, ML Lamoreux, S Ito, K Wakamatsu, EV Sviderskaya, DC Bennett, YM Park, WA Gahl, M Huizing, RA Spritz, S Ben, EK Novak, J Tan, RT Swank

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 102(31) 10964-10969, Aug, 2005
Eumelanin and pheomelanin concentrations in human epidermis before and after UVB irradiation

A Hennessy, C Oh, B Diffey, K Wakamatsu, S Ito, J Rees

PIGMENT CELL RESEARCH, 18(3) 220-223, Jun, 2005
An oxygen transporter hemocyanin can act on the late pathway of melanin synthesis

K Adachi, K Wakamatsu, S Ito, N Miyamoto, T Kokubo, T Nishioka, T Hirata

PIGMENT CELL RESEARCH, 18(3) 214-219, Jun, 2005
Comparisons of the structural and chemical properties of melanosomes isolated from retinal pigment epithelium, iris and choroid of newborn and mature bovine eyes

Y Liu, L Hong, K Wakamatsu, S Ito, BB Adhyaru, CY Cheng, CR Bowers, JD Simon

PHOTOCHEMISTRY AND PHOTOBIOLOGY, 81(3) 510-516, May, 2005
Comparison of structural and chemical properties of black and red human hair melanosomes

Y Liu, L Hong, K Wakamatsu, S Ito, B Adhyaru, CY Cheng, CR Bowers, JD Simon

PHOTOCHEMISTRY AND PHOTOBIOLOGY, 81(1) 135-144, Jan, 2005
Erratum to "Tyrosinase-related proteins suppress tyro sinase-mediated cell death of melanocytes and melanoma cells" (vol 298, pg 317, 2004)

HH Rad, T Yamashita, HY Jin, K Hirosaki, K Wakamatsu, S Ito, K Jimbow

EXPERIMENTAL CELL RESEARCH, 301(2) 338-338, Dec, 2004
Characterization of pigment component in the planarian Dugesia ryukyuensis

Sumitaka Hase, Kazumasa Wakamatsu, Shosuke Ito, Kazuya Kobayashi, Yukiko Sato, Midori Matsumoto, Motonori Hoshi, Sumiko Negishi

ZOOLOGICAL SCIENCE, 21(12) 1330-1330, Dec, 2004
Melanin acts as a cause an atypical potent UVB photosensitizer to mode of cell death in murine skin

S Takeuchi, WG Zhang, K Wakamatsu, S Ito, VJ Hearing, KH Kraemer, DE Brash

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 101(42) 15076-15081, Oct, 2004
Identification of glypican-3 as a novel tumor marker for melanoma

T Nakatsura, T Kageshita, S Ito, K Wakamatsu, M Monji, Y Ikuta, S Senju, T Ono, Y Nishimura

CLINICAL CANCER RESEARCH, 10(19) 6612-6621, Oct, 2004
Pheomelanin production in the epidermis from newborn agouti mice is induced by the expression of the agouti gene in the dermis

T Hirobe, S Takeuchi, E Hotta, K Wakamatsu, S Ito

PIGMENT CELL RESEARCH, 17(5) 506-514, Oct, 2004
A novel RFP-RET transgenic mouse model with abundant eumelanin in the cochlea

H Hayashi, M Sone, S Ito, K Wakamatsu, M Kato, Nakashima, I, T Nakashima

HEARING RESEARCH, 195(1-2) 35-40, Sep, 2004
Red hair, fair skin and melanoma - melanocortin 1 receptor

JL Rees, K Waterston, L Naysmith, C Oh, A Hennessy, Y Bisset, B Diffey, S Ito, K Wakamatsu

EXPERIMENTAL DERMATOLOGY, 13(9) 568-568, Sep, 2004
Tyrosinase-related proteins suppress tyrosinase-mediated cell death of melanocytes and melanoma cells

HH Rad, T Yamashita, HY Jin, K Hirosaki, K Wakamatsu, S Ito, K Jimbow

EXPERIMENTAL CELL RESEARCH, 298(2) 317-328, Aug, 2004
Mutations of the RNA-specific adenosine deaminase gene (ADAR1) are involved in dyschromatosis symmetrica hereditaria

N Suzuki, T Suzuki, Y Miyamura, K Inagaki, M Kono, S Ito, K Fukai, H Takama, Y Tomita

JOURNAL OF INVESTIGATIVE DERMATOLOGY, 123(2), Aug, 2004
The chemical structure of melanin [multiple letters]

William L. Cheun, John D. Simon, Shosuke Ito

Pigment Cell Research, 17(4) 422-424, Aug, 2004
Ion-exchange and adsorption of Fe(III) by Sepia melanin

Y Liu, L Hong, VR Kempf, K Wakamatsu, S Ito, JD Simon

PIGMENT CELL RESEARCH, 17(3) 262-269, Jun, 2004
You can't judge a pigment by its color: Carotenoid and melanin content of yellow and brown feathers in swallows, bluebirds, penguins, and domestic chickens

KJ McGraw, K Wakamatsu, S Ito, PM Nolan, P Jouventin, FS Dobson, RE Austic, RJ Safran, LM Siefferman, GE Hill, R Parker

CONDOR, 106(2) 390-395, May, 2004
Comparison of in vivo anti-melanoma effect of enantiomeric alpha-methyl- and alpha-ethyl-4-S-cysteaminylphenol

J Yukitake, H Otake, S Inoue, K Wakamatsu, S Ito

MELANOMA RESEARCH, 14(2) 115-120, Apr, 2004
Quantitative measures of the effect of the melanocortin 1 receptor on human pigmentary status

L Naysmith, K Waterston, T Ha, N Flanagan, Y Bisset, A Ray, K Wakamatsu, S Ito, JL Rees

JOURNAL OF INVESTIGATIVE DERMATOLOGY, 122(2) 423-428, Feb, 2004
Pheomelanin production in the epidermis from newborn agouti mice is induced by the expression of the agout gene in the dermis

Pigment Cell Research, 17, 506-514, 2004

Books and Other Publications

Chemistry of Melanins. In "The Pigmentary System. Sec Ed. "

Blackwell Publishing, 2006
Advances in chemical analysis of melanins. In"The Pigmentary System and Its Disorders"(共著)

Oxford University Press, New York, 1998
Spectrophotometric and HPLC characterization of hair melanins(共著)

Excerpta Medica International Congress Series 1096. International Symposium on Melanogenesis and Malignant Melanoma, 1996
Biochemistry and Physiology of Melanin in "Pigmentation and Pigmentary Disorders" (共著)

CRC Press, Inc., 1993

Professional Memberships

Works

Research Projects

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