研究者業績
Profile Information
- Affiliation
- Assistant Professor, Mind-Brain Research & Innovation center for Drug Generation, Fujita Health University
- Degree
- Bachelor of Bioengineering(Mar, 2018, University of Yamanashi)Master of Agriculture(Mar, 2020, University of Yamanashi)Ph.D. in Bioengineering(Sep, 2025, University of Yamanashi)
- Other name(s) (e.g. nickname)
- Mizuki Yamamoto
- Researcher number
- 41044366
- J-GLOBAL ID
- 202601005857882883
- researchmap Member ID
- R000114077
Research Areas
1Research History
3-
Apr, 2026 - Present
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Apr, 2025 - Mar, 2026
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Apr, 2020 - Mar, 2023
Papers
10-
Bioscience, Biotechnology, and Biochemistry, 88(2) 147-153, Nov, 2023 Peer-reviewedABSTRACT This research is based on a Systematic Evolution of Ligands by EXponential enrichment, also referred to as in vitro selection against the extracellular domain of human interleukin-17 receptor A (IL-17RA). Pull-down assay via quantitative polymerase chain reaction and chemiluminescence detection showed that the cloned RNA with the enriched sequence bound to human IL-17RA and inhibited the interaction between IL-17RA and human interleukin-17A (IL-17A). We also revealed that the newly discovered IL-17RA-binding RNA aptamer bound to cellular IL-17RA, inhibited the cellular IL-17RA/IL-17A interaction, and antagonized cellular IL-17A signaling.
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Biochemical and Biophysical Research Communications, 614 17-21, Jul, 2022 Peer-reviewed
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Biochemical and Biophysical Research Communications, 610 188-195, Jun, 2022 Peer-reviewed
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Chemical Communications, 58(34) 5237-5240, Jun, 2022 Peer-reviewedWe report novel spontaneous peptide cyclization by intramolecular nucleophilic aromatic substitutions using ribosomally incorporatable and intramolecularly cysteine-reactive fluorobenzoic acid-derived linkers.
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Biochemical and Biophysical Research Communications, 553 148-153, May, 2021 Peer-reviewed
Misc.
34-
日本薬学会年会要旨集(Web), 144th, 2024
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日本薬学会年会要旨集(Web), 144th, 2024
Books and Other Publications
3-
ペプチド医薬品開発のためのスクリーニング・安定化・製剤化技術, Dec, 2017