岡本 薫

Abstract Eczema herpeticum (EH) is a disseminated cutaneous infection with herpes simplex virus (HSV) that develops in patients with atopic dermatitis. The kinetics and clinical significance of HSV viremia in EH are poorly understood. Herein, we report HSV DNAemia in a child with EH 12 months after the completion of chemotherapy for Hodgkin lymphoma.

Objectives: Fish roe is a common allergen in Japan. We have previously reported that although immunoglobulin (IgE) from patients with salmon roe (SR) or pollock roe (PR) allergies cross-react, 70% of patients with SR allergy can consume PR without developing any symptoms. However, a correlation between clinical cross-reactivity and serological cross-reactivity remains to be demonstrated. Methods: Serum samples were collected from 15 patients with SR allergy who had consumed cooked PR previously. Among these volunteers, four had experienced immediate symptoms after consuming cooked PR, while the others had exhibited no symptoms of PR allergy. A competitive enzyme-linked immunosorbent assay (ELISA) was performed to analyze the serological cross-reactivity with SR and PR. Immunoblotting inhibition assays were performed using serum samples that had been pre-incubated with SR or PR extracts. Results: In ELISAs, binding to SR was inhibited by >50% when the serum samples from patients with both SR and PR allergies were pre-incubated with PR extract (p=0.0256). In immunoblots, pre-incubation of serum samples with PR extract inhibited detection of the 16-kDa protein, which likely corresponds to the major SR allergen beta' component, significantly more for samples from patients with both SR and PR allergies (100%) than for samples from those with only an SR allergy (18.2%) (p=0.011). Conclusions: The superior competitive binding of the sera from patients with both SR and PR allergies to PR compared with that to SR may induce clinical cross-reactivity between SR and PR.

某県の歯科医院と市中病院2施設に対してラテックスアレルギー(LA)に関する意識調査を行なった。回答はA病院勤務者419名、B病院勤務者325名、歯科医院勤務者458名より得られた。今回、この調査結果を2005年に報告された明石らによる全国調査と比較した。ゴム手袋で蕁麻疹を起こすことを知っていた割合は60%から90%になっていた。また、アナフィラキシーを起こす可能性があることを知っていた割合は33%から60%になっていた。一方、果物との交差反応性があることを知っていた割合は10%以下から10〜40%に、更に特定のグループに多いことを知っていた割合は10%以下から約50%と、それぞれ認知度が高くなっていることが確認された。特にLAに関する知識が高かったB病院ではラテックスフリー手袋の使用率が高く、ラテックス手袋使用時もパウダーフリーの割合が高いことが明らかとなった。