総合医科学研究所 遺伝子発見機構学
Profile Information
- Affiliation
- professor, Fujita Health Universityなし
- Degree
- PhD(Nagoya University)
- Researcher number
- 10109259
- J-GLOBAL ID
- 200901010615021362
- researchmap Member ID
- 1000102743
- External link
We performed two projects by using the phage antibody technology.
(1) Development of therapeutic antibodies against cancers
We identified 32 kinds of cancer-specific protein antigens that are either specifically or dominantly expressed on the cell surface of cancer tissues. We also succeeded in isolating of several hundreds of human monoclonal antibodies that can specifically and tightly bind to one of the above antigens. We search for the clones that are effective as drugs against various kinds of cancers. According to this strategy, we are going to start the clinical examinations.
(2) Analysis of the repertoire of neutralizing antibodies against influenza viruses in human
We established the strategy for analyzing the neutralizing antibody repertoire against influenza viruses in human. The results indicated that neutralizing antibodies are selected during repetitive infection of viruses whose sequences are gradually changed, and eventually antibodies that bind to the epitope commonly present on all the viruses become dominant in human bodies. This observation is very different from the common sense that is shared among the society of influenza researchers
(1) Development of therapeutic antibodies against cancers
We identified 32 kinds of cancer-specific protein antigens that are either specifically or dominantly expressed on the cell surface of cancer tissues. We also succeeded in isolating of several hundreds of human monoclonal antibodies that can specifically and tightly bind to one of the above antigens. We search for the clones that are effective as drugs against various kinds of cancers. According to this strategy, we are going to start the clinical examinations.
(2) Analysis of the repertoire of neutralizing antibodies against influenza viruses in human
We established the strategy for analyzing the neutralizing antibody repertoire against influenza viruses in human. The results indicated that neutralizing antibodies are selected during repetitive infection of viruses whose sequences are gradually changed, and eventually antibodies that bind to the epitope commonly present on all the viruses become dominant in human bodies. This observation is very different from the common sense that is shared among the society of influenza researchers
Research Interests
30Research Areas
4Research History
8-
Apr, 2011 - Present
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Apr, 2007 - Mar, 2011
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Apr, 1985 - Mar, 2007
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Jul, 1982 - Mar, 1985
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Sep, 1981 - Jun, 1982
Papers
62-
JOURNAL OF VIROLOGY, 88(13) 7130-7144, Jul, 2014 Peer-reviewed
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NATURE COMMUNICATIONS, 5 3614, Apr, 2014 Peer-reviewed
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JOURNAL OF MEDICAL VIROLOGY, 86(4) 558-567, Apr, 2014 Peer-reviewed
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PLOS ONE, 8(4) e61230, Apr, 2013 Peer-reviewed
Misc.
21-
日本外科学会雑誌, 110(2), Feb 25, 2009
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日本婦人科腫瘍学会雑誌 = The journal of the Japan Society of Gynecologic Oncology, 26(3) 214-215, Jun 25, 2008
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日本泌尿器科學會雜誌, 99(2) 484-484, Feb 20, 2008
Presentations
5-
Bio Asia, Hyderabad, India, Feb, 2010 Invited
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Protein Engineering Summit, Hanonover, Germanuy, Sep, 2009 Invited
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The 57th Fall Conferance of the Korean Association of Immunologists., Nov, 2008 Invited
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The sixth JSPS Science Forum in Stockholm, Frontiers in Influenza Research., Mar, 2007
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The third international workshop by Fujita Health University 21st centry COE, Feb, 2006
Teaching Experience
1-
免疫学 (藤田保健衛生大学)