Curriculum Vitaes

Ken'ichi Inada

(稲田健一)

Profile Information

Affiliation: School of Medicine Faculty of Medicine, Fujita Health University

Degree: MD.PhD(Tokai University)

J-GLOBAL ID: 200901082865010243
researchmap Member ID: 0000002032

Research Interests

2

Research Areas

2

Research History

1

Associate Professor, Fujita Health University School of Medicine, Faculty of Medicine, 1st Department of Pathology

Misc.

129

Mizoshita T, Inada K, Tsukamoto T, Nozaki K, Joh T, Itoh M, Yamamura Y, Ushijima T, Nakamura S, Tatematsu M. Expression of the intestine-specific transcription factors, Cdx1 and Cdx2, correlates shift to an intestinal phenotype in gastric cancer cells.

J Cancer Res Clin Oncol., 130(1) 29-36, 2004
Mizoshita T, Inada K, Tsukamoto T, Nozaki K, Joh T, Itoh M, Yamamura Y, Ushijima T, Nakamura S, Tatematsu M. Expression of the intestine-specific transcription factors, Cdx1 and Cdx2, correlates shift to an intestinal phenotype in gastric cancer cells.

J Cancer Res Clin Oncol., 130(1) 29-36, 2004
Stem cells and gastric cancer: Role of gastric and intestinal mixed intestinal metaplasia

M Tatematsu, T Tsukamoto, K Inada

CANCER SCIENCE, 94(2) 135-141, Feb, 2003
Koike M, Inada K, Nakanishi H, Matsuura A, Nakamura S, Tatematsu M. Cellular differentiation status of epithelial polyps of the colorectum : the gastric foveolar cell-type in hyperplastic polyps.

Histopathology., 42(4) 357-64, 2003
Nozaki K, Shimizu N, Ikehara Y, Inoue M, Tsukamoto T, Inada K, Tanaka H, Kumagai T, Kaminishi M, Tatematsu M. Effect of early eradication on Helicobacter pylori-related gastric carcinogenesis in Mongolian gerbils.

NOZAKI K, SHIMIZU N, IKEHARA Y, INOUE M, TSUKAMOTO T, TANAKA H, KUMAGAI T, KAMINISHI M, TATEMATSU M

Cancer Sci., 94(3) 235-239, 2003
Effect of a tyrosine kinase inhibitor ST1571 in a patient with hepatic metastases from a duodenal gastrointestinal stromal tumor

A Sawaki, K Ohashi, K Yamao, K Inada, Y Shimizu, A Matsuura, T Nakamura, T Suzuki, K Hara, K Okubo, R Ohno

JOURNAL OF GASTROENTEROLOGY, 38(7) 690-694, 2003
Mizoshita T, Tsukamota T, Nakanishi H, Inada K, Ogasawara N, Joh T, Itoh M, Yamamura Y, Tatematsu M. Expression of Cdx2 and the phenotype of advanced gastric cancers : relationship with prognosis.

J Cancer Res Clin Oncol., 129(12) 727-34, 2003
Nishiumi N, Abe Y, Inoue Y, Hatanaka H, Inada K, Kijima H, Yamazaki H, Tatematsu M, Ueyama Y, Iwasaki M, Inoue H, Nakamura M. Use of 11p15 mucins as prognostic factors in small adenocarcinoma of the lung.

Clin Cancer Res., 9(15) 5616-9, 2003
Tsukamoto T, Inada K, Tanaka H, Mizoshita T, Mihara M, Ushijima T, Yamamura Y, Nakamura S, Tatematsu M. Down-regulation of a gastric transcription factor, Sox2, and ectopic expression of intestinal homeobox genes, Cdx1 and Cdx2 : inverse correlation du・・・

J Cancer Res Clin Oncol., 2003

Tsukamoto T, Inada K, Tanaka H, Mizoshita T, Mihara M, Ushijima T, Yamamura Y, Nakamura S, Tatematsu M. Down-regulation of a gastric transcription factor, Sox2, and ectopic expression of intestinal homeobox genes, Cdx1 and Cdx2 : inverse correlation during progression from gastric/intestinal-mixed to complete intestinal metaplasia.
Koike M, Inada K, Nakanishi H, Matsuura A, Nakamura S, Tatematsu M. Cellular differentiation status of epithelial polyps of the colorectum : the gastric foveolar cell-type in hyperplastic polyps.

Histopathology., 42(4) 357-64, 2003
Tatematsu M, Tsukamoto T, Inada K. Stem cells and gastric cancer : role of gastric and intestinal mixed intestinal metaplasia.

Cancer Sci., 94(2) 135-141, 2003
Nozaki K, Shimizu N, Ikehara Y, Inoue M, Tsukamoto T, Inada K, Tanaka H, Kumagai T, Kaminishi M, Tatematsu M. Effect of early eradication on Helicobacter pylori-related gastric carcinogenesis in Mongolian gerbils.

Cancer Sci., 94(3) 235-239, 2003
Sawaki A, Ohashi K, Yamao K, Inada K, Shimizu Y, Matsuura A, Nakamura T, Suzuki T, Hara K, Okubo K, Ohno R. Effect of a tyrosine kinase inhibitor STI571 in a patient with hepatic metastases from a duodenal gastrointestinal stromal tumor.

J Gastroenterol, 38(7) 690-694, 2003
Mizoshita T, Tsukamota T, Nakanishi H, Inada K, Ogasawara N, Joh T, Itoh M, Yamamura Y, Tatematsu M. Expression of Cdx2 and the phenotype of advanced gastric cancers : relationship with prognosis.

J Cancer Res Clin Oncol., 129(12) 727-34, 2003
Nishiumi N, Abe Y, Inoue Y, Hatanaka H, Inada K, Kijima H, Yamazaki H, Tatematsu M, Ueyama Y, Iwasaki M, Inoue H, Nakamura M. Use of 11p15 mucins as prognostic factors in small adenocarcinoma of the lung.

Clin Cancer Res., 9(15) 5616-9, 2003
Tsukamoto T, Inada K, Tanaka H, Mizoshita T, Mihara M, Ushijima T, Yamamura Y, Nakamura S, Tatematsu M. Down-regulation of a gastric transcription factor, Sox2, and ectopic expression of intestinal homeobox genes, Cdx1 and Cdx2 : inverse correlation du・・・

J Cancer Res Clin Oncol., 2003

Tsukamoto T, Inada K, Tanaka H, Mizoshita T, Mihara M, Ushijima T, Yamamura Y, Nakamura S, Tatematsu M.<br /> Down-regulation of a gastric transcription factor, Sox2, and ectopic expression of intestinal homeobox genes, Cdx1 and Cdx2 : inverse correlation during progression from gastric/intestinal-mixed to complete intestinal metaplasia.
Sugiyama Y, Kato T, Nakazato H, Ito K, Mizuno I, Kanemitsu T, Matsumoto K, Yamaguchi A, Nakai K, Inada K, Tatematsu M. Retrospective study on thymidylate synthase as a predictor of outcome and sensitivity to adjuvant chemotherapy in patients with curat・・・

Anticancer Drugs., 13(9) 931-8, 2002

Sugiyama Y, Kato T, Nakazato H, Ito K, Mizuno I, Kanemitsu T, Matsumoto K, Yamaguchi A, Nakai K, Inada K, Tatematsu M. Retrospective study on thymidylate synthase as a predictor of outcome and sensitivity to adjuvant chemotherapy in patients with curatively resected colorectal cancer.
Synergistic Promoting Effects of Helicobacter pylori Infection and High-salt Diet on Gastric Carcinogenests in Mongolian Gerbils

Jpn. J. Cancer Res., 93,1083-1089, 2002
Reversibility of heterotopic proliferative glands in glandular stomach of Helicobacter pylori-infected Mongolian

Gerbils on eradication, Jpn. J. Cancer Res., 93,374-381, 2002
Independent variation in susceptibilities of six different mouse strains to induction of pepsinogh-altered pyloric glands and gastric tumor intestinalization by N-methyl-N-nitrosoureer

Cancer Lett, 179,121-132, 2002
Helicobacter pylori 感染と胃癌発生

日本消化器病学会雑誌, 99(3), 247-252, 2002
Sugiyama Y, Kato T, Nakazato H, Ito K, Mizuno I, Kanemitsu T, Matsumoto K, Yamaguchi A, Nakai K, Inada K, Tatematsu M. Retrospective study on thymidylate synthase as a predictor of outcome and sensitivity to adjuvant chemotherapy in patients with curat・・・

Anticancer Drugs., 13(9) 931-8, 2002

Sugiyama Y, Kato T, Nakazato H, Ito K, Mizuno I, Kanemitsu T, Matsumoto K, Yamaguchi A, Nakai K, Inada K, Tatematsu M.<br /> Retrospective study on thymidylate synthase as a predictor of outcome and sensitivity to adjuvant chemotherapy in patients with curatively resected colorectal cancer.
Synergistic Promoting Effects of Helicobacter pylori Infection and High-salt Diet on Gastric Carcinogenests in Mongolian Gerbils

Jpn. J. Cancer Res., 93,1083-1089, 2002
A phenotypic shift from gastric-intestinal to solely intestinal cell types in intestinal metaplasia in rat stomach following treatment with X-rays

Hirofumi Yuasa, Ken-Ichi Inada, Hiromitsu Watanabe, Masae Tatematsu

Journal of Toxicologic Pathology, 15(2) 85-93, 2002
Reversibility of heterotopic proliferative glands in glandular stomach of Helicobacter pylori-infected Mongolian

Gerbils on eradication, Jpn. J. Cancer Res., 93,374-381, 2002
Independent variation in susceptibilities of six different mouse strains to induction of pepsinogh-altered pyloric glands and gastric tumor intestinalization by N-methyl-N-nitrosoureer

Cancer Lett., 179,121-132, 2002
Polymorphisms of Two Fucosyltransberase Genes (Lewis and Secretor Genes) Involving Type I Lewis Antigens Are Associated with the Presence of Anti-Helicobacter pylori IgG Antibody

Cancer Epidemiol. Biomark. Prev., 10,971-977, 2001
Real-time reverse transcriptase polymerase chain reaction of urinary cytokeratin 20 detects transitional cell carcinoma cells.

J.Urol., 166, 2134-2141, 2001
Squential histopathological changes in vivo after suicide gene therapy of gastric cancer induced by N-methyl-N'-nitro-N-nitrosoguanidine in rats.

Jpn.J.Cancer Res., 92, 673-679, 2001
Identification of Paneth cells in pyloric glands associated with gastric and intestinal mixed type intestinal metaplasia of the human stomach.

Virchows Arch., 439, 14-20, 2001
Polymorphisms of Two Fucosyltransberase Genes (Lewis and Secretor Genes) Involving Type I Lewis Antigens Are Associated with the Presence of Anti-Helicobacter pylori IgG Antibody

Cancer Epidemiol. Biomark. Prev., 10,971-977, 2001
Real-time reverse transcriptase polymerase chain reaction of urinary cytokeratin 20 detects transitional cell carcinoma cells.

J.Urol., 166, 2134-2141, 2001
Squential histopathological changes in vivo after suicide gene therapy of gastric cancer induced by N-methyl-N'-nitro-N-nitrosoguanidine in rats.

Jpn.J.Cancer Res., 92, 673-679, 2001
Identification of Paneth cells in pyloric glands associated with gastric and intestinal mixed type intestinal metaplasia of the human stomach.

Virchows Arch, 439, 14-20, 2001
Expression of cathepsin e and its suppression with intestinalization in epithelial cells and tumor cells in rat glandular stomach treated with N-methyl-N'-nitro-N-nitrosoguanidine

Hirofumi Yuasa, Satoshi Yoneyama, Masao Ichinose, Kazumasa Miki, Tetsuya Tsukamoto, Ken-Ichi Inada, Masae Tatematsu

Journal of Toxicologic Pathology, 14(1) 29-35, 2001
Mouse strain susceptibility to diethylnitrosamine induced hepatocarcinogenesis is cell autonomous whereas sex-susceptibility is due to the micro-environment:analysis with C3H<->BALB/c sexually chimeric mice.

Jpn.J.Cancer Res., 91, 665-673, 2000
Summation of initiation activities of low doses of the non-hepatocarcinogen 1.2-dimethylhydrazine in the liver after carbon tetrachloride administration.

Cancer Letters, 148, 59-63, 2000
Eradication diminishes enhancing effects of Helicobacter pylori infection on glandular stomach carcinogenesis in Mongolian gerbils.

Cancer Res., 60, 1512-1514,, 2000
Mouse strain susceptibility to diethylnitrosamine induced hepatocarclinogenesis is cell autonomous whereas sex-susceptibility is due to the micro-environment:analysis with C3H<->BALB/c sexually chimeric mice.

Jpn.J.Cancer Res., 91, 665-673, 2000
Summation of initiation activities of low doses of the non-hepatocarcinogen 1.2-dimethylhydrazine in the liver after carbon tetrachloride administration.

Cancer Letters, 148, 59-6, 2000
Eradication diminishesenhancing effects of Helicobacter pylori infection on glandular stomach carcinogenesis in Mongolian gerbils.

Cancer Res., 60, 1512-1514, 2000
Induction of apoptosis in metastatic foci from human gastric cancer xenografts in nude mice and reduction of circulating tumor cells in blood by 5-FU and 1-hexylcarbamoyl-5-fluorouracil.

J. Cancer Res. Clin. Oncol., 125, 660-668, 1999
Helicobacter pylori infection enhances glandular stomach carcinogenesis in Mongolian gerbils treated with chemical carcinogens.

Carcinogenesis:, 20, 4, 669-676, 1999
Effects of low dose catechol on glandular stomach carcinogenesis in BALB/c mice initiated with N-methyl-N-nitrosourea.

Cancer Lett., 139, 167-172, 1999
Chemosensitivity of micrometastases and circulating tumor cells to uracil and tegafur as evaluated using LacZ gene-tagged Lewis lung carcinoma cell.

Cancer Lett., 142, 31-41,, 1999
Induction of apoptosis in metastatic foci from human gastric cancer xenografts in nude mice and reduction of circulating tumor cells in blood by 5-FU and 1-hexylcarbamoyl-5-fluorouracil.

J. Cancer Res. Clin. Oncol., 125, 660-668, 1999
Helicobacter pylori infection enhances glandular stomach carcinogenesis in Mongolian gerbils treated with chemical carcinogens.

Carcinogenesis:, 20, 4, 669-676,, 1999
Effects of low dose catechol on glandular stomach carcinogenesis in BALB/c mice initiated with N-methyl-N-nitrosourea.

Cancer Lett., 139, 167-172, 1999
Chemosensitivity of micrometastases and circulating tumor cells to uracil and tegafur as evaluated using LacZ gene-tagged Lewis lung carcinoma cell.

Cancer Lett., 142, 31-41, 1999
Phenotypic shift in human differentiated gastric cancers from gastric to intestinal epithelial cell type during disease progression.

Gastric Cancer, 1, 134-141, 1998

Books and Other Publications

39

器官培養法を用いたヒト胃粘膜腸上皮化生腺管の細胞動態 -腺管分離法による解析-

消化器癌発生学会編、消化器癌の発生と進展10、靖文社、東京、, 1998
p53 knockoutマウスにおけるN-methyl-N-nitrosourea誘発胃癌

消化器癌発生学会編、消化器癌の発生と進展10、靖文社、東京, 1998
MNU誘発キメラマウス腺胃腫瘍の組織発生と発育進展形式の検討

消化器癌発生学会編、消化器癌の発生と進展10、靖文社、東京、, 1998
Helicobacter pylori感染の胃癌発生増強作用 -スナネズミモデルの検討-

消化器癌発生学会編、消化器癌の発生と進展10、靖文社、東京、, 1998
Helicobacter pylori infection enhances glandular stomach carcinogenesis in Mongolian gerbils treated with chemical carcinogens.

J. Jpn. Society Gastroenterol. Carcinogenesis (in Japanese), 1998

Professional Memberships

7

Research Projects

4

消化管粘膜における細胞分化

共同研究, 1999
Celluler differentiation of gastrointestinal mucosa

Cooperative Research, 1999
腸上皮化生

科学研究費補助金, 1995
Intestinal metaplasia

Grant-in-Aid for Scientific Research, 1995

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