須田 隆

We report the surgical technique for subxiphoid robotic thymectomy with combined superior vena cava (SVC) resection. A blood-drainage cannula was inserted into the left internal jugular vein as a blood-drainage route. A blood infusion cannula was inserted into the left femoral vein. During SVC clamping, an assistant pumped blood through the circuit to prevent clotting. The tumour, SVC, thymus, part of the pericardium and part of the right lung were excised en bloc through a subxiphoid incision. We limited reconstruction to the right brachiocephalic-SVC anastomosis. Robotic-assisted thymectomy via the subxiphoid approach enables SVC replacement, which was previously feasible only with open surgery.

BACKGROUND: Uniportal thoracoscopic surgery has gained popularity as a minimally invasive approach for anatomical lung resection. While outcomes from high-volume centers have been reported, evidence describing nationwide real-world practice across institutions with varying experience is scarce. This study aimed to evaluate the current status and perioperative outcomes of uniportal thoracoscopic anatomical pulmonary resections in Japan. METHODS: We conducted a multicenter retrospective study under the Japanese Uniportal Video-assisted Thoracoscopic Surgery Interest Group. Patients with primary lung cancer who underwent uniportal thoracoscopic lobectomy or segmentectomy in Japan between April 2018 and March 2023 were included. Clinical information was collected from participating institutions, and patient characteristics, operative variables, and perioperative outcomes were evaluated. The primary outcome was the incidence of procedure-related complications, with secondary outcomes including operative time and other perioperative parameters. RESULTS: A total of 3,546 patients were analyzed, comprising 2,780 lobectomies and 766 segmentectomies. The proportion of segmentectomies gradually increased during the study period. In the lobectomy group, the median operative time was 170 min, with prolonged air leak in 7.6% and significant vessel injury in 3.4%. In the segmentectomy group, the median operative time was 154 min, with prolonged air leak in 4.6% and significant vessel injury in 3.5%. Thirty-day mortality was 0.3% in both groups, and conversion to multiport or thoracotomy occurred in 1.8-3.6% of cases. CONCLUSIONS: This nationwide analysis indicates that uniportal thoracoscopic anatomical pulmonary resection is performed safely in Japan, with perioperative outcomes comparable to those reported internationally. Although operative times were slightly longer than those in single-institution series, complication rates remained low, indicating that uniportal thoracoscopic anatomical pulmonary resection is being conducted with acceptable perioperative outcomes in real-world practice.

Uniportal video-assisted thoracoscopic surgery (VATS) is considered the optimal access method for pneumothorax surgery. Currently, uniportal VATS is used worldwide because it requires an incision in only one intercostal space, which simplifies postoperative pain control, due to reduced acute pain, and the incidence of chronic pain is also potentially lower. It is essential to tailor the surgical technique to each individual case, ensure reliable closure of air leaks, and minimize the risk of recurrence. This article introduces the practical aspects of uniportal VATS for pneumothorax, focusing on the pitfalls. Moreover, detailed methodologies for the lateral intercostal approach for uniportal lung wedge resection, and subxiphoid uniportal bilateral lung resection are provided. During lung resection (bullectomy) for primary spontaneous pneumothorax, the reinforcement-equipped cartridge is used to prevent recurrence, and an oxidized regenerated cellulose sheet is applied as a covering material. In the case of secondary spontaneous pneumothorax, in addition to the oxidized regenerated cellulose sheet, the most appropriate reinforcement material is applied after the surgical procedure. During lung resection, the planned resection line should be marked as needed to clearly define the resection area and ensure no residual lesions are left behind. When partial lung resection is challenging, or in cases of air leakage from a pedunculated bulla, suture closure or ligation may be required. The most common approaches include direct suturing of the damaged pleura or ligating the base of the bulla. Given the condition of the underlying lung, reinforcement with covering materials is essential in all cases. This article includes numerous visual materials, including figures and videos, to illustrate the uniportal VATS technique for pneumothorax. Irrespective of the technique used, it is necessary for clinicians to undergo training, refine their skills, and select the appropriate instruments.

OBJECTIVE: Thymomas sometimes are located in the cervical region, and strategies are needed to safely remove these tumors. The purpose of this study was to evaluate the feasibility and safety of subxiphoid robotic thymectomy (SRT) for anterior mediastinal tumors located in cervical region. METHODS: This was a retrospective database review of patients who underwent SRT from January 2011 to April 2024. Of the 81 patients who underwent SRT for anterior mediastinal tumors, 79 patients were included, excluding 2 patients who underwent reconstruction using artificial blood vessels. RESULTS: In total, 41 patients in whom part of the tumor was located above or in contact with the innominate vein were classified as group A, and 38 patients in which the tumor was located caudal to the innominate vein were classified as group B. The patients in group A were significantly younger (median, 54 years vs 63 years; P = .035). There were no differences in perioperative data between the 2 groups: operative time (median, 192 vs 188 minutes; P = .961), intraoperative blood loss (median: 5 vs 5 g; P = .235), combined resection rate (17.1% vs 21.1%; P = .776), duration of thoracic drain insertion (median: 1 vs 1 day; P = .221), postoperative hospital stay (median: 4 vs 4 day; P = .694), and postoperative complications (9.8% vs 5.3%; P = .677). Conversion to other approaches and perioperative mortality were not observed in either group. CONCLUSIONS: SRT, which enables full visualization of the innominate vein from the midline view, may offer increased safety for complicated thymectomies, including those requiring combined resection of the innominate vein, and may demonstrate safety comparable with that of procedures performed for cases caudal to the innominate vein.

BACKGROUND: Postoperative pneumonia is a serious lung cancer surgery complication. Perioperative oral management can help prevent its development. OBJECTIVES: This study aimed to determine the characteristics of patients who developed postoperative pneumonia despite perioperative oral management. METHODS: This study included 396 consecutive patients who underwent lung cancer surgery under general anesthesia at Fujita Health University Okazaki Medical Center from April 2020, the opening of the hospital, to the end of December 2023. Patient data, including age, gender, body mass index, underlying disease, smoking index, spirogram, operative time, amount of blood loss during operation, and operative procedure, were obtained from medical records. Oral examinations were conducted to determine the number of remaining teeth and whether dental caries are present and to examine tooth mobility and probing pocket depths > 4 mm. Furthermore, the patients were asked whether they had regular dental checkups. The patients were divided into the pneumonia and no-pneumonia groups following lung surgery, and the factors involved in postoperative pneumonia were investigated. RESULTS: A total of 390 patients were analyzed (six were excluded), of whom 33 developed postoperative pneumonia. Among them, 17 were excluded from the analysis due to preoperative interstitial pneumonia. Consequently, the incidence of postoperative pneumonia was 16 of 373 patients (4.3%). Significant differences were observed between the groups in terms of age, sex, chronic obstructive pulmonary disease, smoking index, operative time, number of remaining teeth, and regular dental checkups. Logistic regression analysis using these significant items revealed that fewer than 20 remaining teeth were significantly associated with the development of postoperative pneumonia (p = 0.043). CONCLUSIONS: The results of this study indicated that the incidence of postoperative pneumonia following perioperative oral function management was maintained as low as that reported previously. The importance of dental intervention in the perioperative period was also elucidated. A high number of patients who developed postoperative pneumonia despite these interventions had fewer than 20 remaining teeth, suggesting that more attention should be paid to perioperative oral management, including the prevention of aspiration pneumonia.

OBJECTIVES: Uniportal video-assisted thoracoscopic surgery (U-VATS) is gaining global recognition as a minimally invasive approach. However, its current status and issues in Japan remain unclear. This study aimed to assess U-VATS adoption and barriers among Japanese thoracic surgeons through a nationwide survey. METHODS: The Japanese Uniportal VATS Interest Group conducted an online survey of 3287 thoracic surgeons on the Japan Association for Chest Surgery mail list. Responses were collected from October 25 to November 30, 2024, yielding 851 valid responses (25.9%) from 497 institutions (78.0% of JACS-registered institutions). RESULTS: The adoption rate of U-VATS among the institutions was 42.5%. However, the proportions of thoracic surgeons who primarily performed lobectomy, segmentectomy, and wedge resection using U-VATS were 10.3%, 10.2%, and 22.0%, respectively. The main reasons for non-adoption included concerns regarding safety and surgical precision (57.2%), preference for other approaches (50.9%), and lack of instruments (48.8%). Among surgeons with no prior U-VATS experience, 34.1% were willing to adopt it. To facilitate broader adoption, respondents highlighted the need for troubleshooting resources (61.3%), high-precision surgical videos (59.0%), and hands-on training programs (51.5%). CONCLUSION: Despite the relatively high institutional adoption rate, the proportion of thoracic surgeons using U-VATS as the primary approach remained low. Key barriers include concerns about safety and surgical precision, limited educational opportunities, and a lack of scientific evidence on U-VATS in Japan. To promote the wider adoption of U-VATS, it is essential to develop structured educational programs and generate evidence to ensure both safety and surgical precision.

OBJECTIVES: Uniportal video-assisted thoracoscopic surgery (U-VATS) is gaining global recognition as a minimally invasive approach. However, its current status and issues in Japan remain unclear. This study aimed to assess U-VATS adoption and barriers among Japanese thoracic surgeons through a nationwide survey. METHODS: The Japanese Uniportal VATS Interest Group conducted an online survey of 3287 thoracic surgeons on the Japan Association for Chest Surgery mail list. Responses were collected from October 25 to November 30, 2024, yielding 851 valid responses (25.9%) from 497 institutions (78.0% of JACS-registered institutions). RESULTS: The adoption rate of U-VATS among the institutions was 42.5%. However, the proportions of thoracic surgeons who primarily performed lobectomy, segmentectomy, and wedge resection using U-VATS were 10.3%, 10.2%, and 22.0%, respectively. The main reasons for non-adoption included concerns regarding safety and surgical precision (57.2%), preference for other approaches (50.9%), and lack of instruments (48.8%). Among surgeons with no prior U-VATS experience, 34.1% were willing to adopt it. To facilitate broader adoption, respondents highlighted the need for troubleshooting resources (61.3%), high-precision surgical videos (59.0%), and hands-on training programs (51.5%). CONCLUSION: Despite the relatively high institutional adoption rate, the proportion of thoracic surgeons using U-VATS as the primary approach remained low. Key barriers include concerns about safety and surgical precision, limited educational opportunities, and a lack of scientific evidence on U-VATS in Japan. To promote the wider adoption of U-VATS, it is essential to develop structured educational programs and generate evidence to ensure both safety and surgical precision.

We report subxiphoid uniportal robotic thymectomy without intercostal access using the da Vinci Xi multi-port robot system. A 4-cm vertical incision was made 1 cm caudal to the xiphoid process. The AIRSEAL ROBOTIC SOLUTION, an air seal system compatible with the da Vinci port was used to insufflate CO2 at 8 mmHg. During port insertion, the left and right hands were crossed into the wound, with the camera, left hand, and right hand inserted in the order from the anterior chest to the dorsal side. To reduce the interference between the ports at the head, a key technique is to pull the camera port forward to prevent it from colliding with the other ports. Subxiphoid uniportal robotic thymectomy using the da Vinci Xi is a technique that combines excellent surgical visibility from the subxiphoid process, minimal invasiveness and enhanced operability provided by the robotic system.

We performed the first case of major lung resection using the hinotori™ surgical robot system, which is a new surgical support robot system developed in Japan. A left lower lobectomy and subcarinal lymph node dissection were performed. The operation time was 3 h and 5 min, the cockpit time (console time) was 2 h and 5 min, and the blood loss was 40 g. Although the hinotori™ surgical robot system requires further improvements to be used for lung cancer surgery, even in its current state, there is no difference in operability compared to the da Vinci robot, and it is possible to perform the same surgery. Further evaluation with additional cases is required in future.

BACKGROUND: We previously reported on subxiphoid uniportal thymectomy (SUT) and subxiphoid robotic thymectomy (SRT). This descriptive study aimed to evaluate the feasibility and safety of both SUT and SRT techniques. METHODS: Between March 2011 and December 2022, 268 patients underwent subxiphoid thymectomy. In cases demonstrating no evidence of invasion into other organs, SUT was selected due to its minimal invasiveness. In cases where the tumor was in contact with the innominate vein or those with suspected invasion into other organs, SRT with additional intercostal ports was selected due to the enhanced operability provided by the robotic system. The patients' backgrounds and the perioperative outcomes of each technique were evaluated. RESULTS: SUT was performed in 207 patients, while SRT was performed in 61 patients. In the SUT group, 15 patients required an additional intercostal port, and 2 patients required a median sternotomy; the SUT completion rate was 91.78%. The median operative time was 117.00 [interquartile range (IQR), 88.00-148.50] min, with a median blood loss of 5.00 (IQR, 1.00-5.00) mL. Combined resection was performed in 11 (5.31%) patients, and postoperative complications were observed in 4 patients (1.93%). None of the patients in the SRT group required median sternotomy. The median operative time was 203.00 (IQR, 158.00-278.00) min, with a median blood loss of 5.00 (IQR, 5.00-22.00) mL. Combined resection was performed in 14 patients (22.95%), and postoperative complications were observed in 5 patients (8.20%). No mortalities occurred in either group. CONCLUSIONS: Subxiphoid thymectomy is a safe and feasible technique for both early and advanced stages of the disease requiring complex surgical procedures.

The potential advantages of video-assisted thoracoscopic surgery (VATS) for children include better cosmetic outcomes and reduced risk of postoperative musculoskeletal deformities. The uniportal approach is expected to promote minimally invasive surgery and help reduce the incidence of postoperative musculoskeletal deformities. Uniportal VATS was performed safely in three children (mean age of 23.3 months) with congenital pulmonary airway malformation or extralobar pulmonary sequestration. Our findings suggest that minimally invasive lobectomy may be achieved through uniportal VATS in children.

BACKGROUND: Lung cancer frequently occurs in lungs with background idiopathic interstitial pneumonias (IIPs). Limited resection is often selected to treat lung cancer in patients with IIPs in whom respiratory function is already compromised. However, accurate surgical margins are essential for curative resection; underestimating these margins is a risk for residual lung cancer after surgery. We aimed to investigate the findings of lung fields adjacent to cancer segments affect the estimation of tumor size on computed tomography compared with the pathological specimen. METHODS: This analytical observational study retrospectively investigated 896 patients with lung cancer operated on at Fujita Health University from January 2015 to June 2020. The definition of underestimation was a ≥10 mm difference between the radiological and pathological maximum sizes of the tumor. RESULTS: The lung tumors were in 15 honeycomb, 30 reticulated, 207 emphysematous, and 628 normal lungs. The ratio of underestimation in honeycomb lungs was 33.3% compared to 7.4% without honeycombing (P=0.004). Multivariate analysis showed that honeycombing was a significant risk factor for tumor size underestimation. A Bland-Altman plot represented wide 95% limits of agreement, -40.8 to 70.2 mm, between the pathological and radiological maximum tumor sizes in honeycomb lungs.

A 49-year-old female was underwent laparoscopic right hemicolectomy for ascending colon cancer and liver metastasis. Then, she was underwent laparoscopic hepatectomy. She received BEV plus mFOLFOX6 therapy as postoperative adjuvant chemotherapy, but she had liver recurrence. She received FOLFOXIRI therapy. Although tumor tended to progressive, it was localized, so laparoscopic hepatectomy was performed again. She received AFL plus FOLFIRI therapy. Fourteen months after hepatic resection, disseminated nodules and lung metastases were found. However, both of peritoneal dissemination, and lung metastasis were localized, so it was judged that peritoneal dissemination and lung metastasis could be resectable. Then, peritoneal dissemination resection and sigmoid colectomy were performed, and then lung resection was performed to perform R0 resection. R0 resection and multimodal therapy for simultaneous and heterotopic metastases of colorectal cancer can contribute to provide a long-term prognosis.

OBJECTIVE: To determine whether robotic-assisted lobectomy (RAL) affects perioperative outcomes and long-term efficacy in non-small cell lung cancer (NSCLC) patients, compared with traditional video-assisted lobectomy (VAL). SUMMARY BACKGROUND DATA: RAL is a promising treatment for NSCLC. However, its efficacy has not been fully evaluated. METHODS: A single-center, open-labeled prospective randomized clinical trial was launched in May 2017 to compare the efficacy of RAL and VAL. By May 2020, 320 patients were enrolled. The perioperative results of RAL and VAL were compared. RESULTS: The 320 enrolled patients were randomly assigned to the RAL group (n = 157) and the VAL group (n = 163). Perioperative outcomes were comparable between the two groups, including the length of hospital stay (P = 0.76) and the rate of postoperative complications (P = 0.45). No perioperative mortality occurred in either group. The total amount of chest tube drainage (830 ml [IQR, 550-1130 ml] vs. 685 ml [IQR, 367.5-1160 ml], P = 0.007) and hospitalization costs ($12821 [IQR, $12145-$13924] vs. $8009 [IQR, $7014-$9003], P < 0.001) were significantly higher in the RAL group. RAL group had a significantly higher number of lymph nodes (LNs) harvested (11 [IQR, 8-15] vs. 10 [IQR, 8-13], P = 0.02), higher number of N1 LNs (6 [IQR, 4-8] vs. 5 [IQR, 3-7], P = 0.005), and more LN stations examined (6 [IQR, 5-7] vs. 5 [IQR, 4-6], P < 0.001). CONCLUSIONS: Both RAL and VAL are safe and feasible for the treatment of NSCLC. RAL achieved similar perioperative outcomes, together with higher LN yield. Further follow-up investigations are required to evaluate the long-term efficacy of RAL. (ClinicalTrials.gov identifier: NCT03134534).

We report a lateral approach using the grasping technique for uniportal major lung resection. Grasping dissected tissue with grasping forceps enables the dissected surface to be three-dimensionally dissected from important organs, such as blood vessels, which, therefore, makes the procedure safe. Furthermore, there is an incision wound on the middle axillary line at the 6th intercostal space, and therefore, either the anterior or posterior side of the hilum can be easily observed, and a stapler can pass through all structures of the hilum easily.

INTRODUCTION: Thoracoscopic lobectomy for primary lung cancer is performed at many institutions. However, few reports are available on postoperative prognosis for progressive stages. In 2004, we adopted lobectomy by video-assisted thoracoscopic surgery (VATS), which would be applicable to the clinical stages up to stage IIIA. This study reports long-term outcomes of surgery for primary lung cancer at several stages, including IIIA. METHODS: We compared the long-term outcomes of 315 VATS cases with those of 159 open thoracotomy cases. RESULTS: The overall 5-year survival rate was 78.1% for the VATS group and 61.9% for the open thoracotomy group. A statistically significant difference between the survival curves of the two groups was observed (P = .001). When analyzing the survival curves for both groups by pathological (p) stage, significant differences were observed for p-stages IB and IIIA, with the VATS group producing better results than the open thoracotomy group. CONCLUSION: The long-term outcomes of patients with primary lung cancer at our institution were more favorable in the group undergoing VATS lobectomy than in the group undergoing open thoracotomy.

OBJECTIVES: The aim of the present study was to examine some initial results and learning curves concerning subxiphoid single-port thymectomy (SSPT), thereby clarifying the safety of this surgical approach and describing the precautions for adopting it. METHODS: From March 2011 to August 2019, a total of 203 patients underwent thymectomy for either anterior mediastinal tumours or myasthenia gravis at Fujita Health University Hospital. Of these 203 patients, 147 patients who had undergone SSPT were selected as participants for the present study. RESULTS: Of the 147 cases, transition to a different approach was required in three (2.0%) cases: two (1.3%) cases transitioned to median sternotomy, whereas one (0.7%) case transitioned to the side chest trans-intercostal approach. The two cases that transitioned to median sternotomy were the second cases for different operators after they began performing this technique. There were six (4.0%) cases with complications and no deaths. The operation time cumulative summation learning curve analysis revealed that the curves descended from the 38th case. In the 83 cases handled by one surgeon, the learning curves descended from the 31st case. CONCLUSIONS: SSPT is a safe modality with few complications and no associated cases of mortality reported. Operators are required to experience 31-38 cases until the operation time for SSPT was stabilized. Special care should be exercised to prevent vascular damage in the vicinity of the innominate veins during the early stages after SSPT introduction.

Subxiphoid uniportal bilateral lung wedge resection, in which all manipulations are performed via a 3-cm wound positioned below the xiphoid process, can be performed in the supine position without the patient having to change positions. It also enables one-stage bilateral lung resection. We report the surgical procedure and initial results of subxiphoid uniportal bilateral lung wedge resection. A 3-cm transverse incision was made 1 cm caudally below the xiphoid process. A port for uniportal surgery was inserted. After CO2 insufflation at 8 mmHg, the lung was grasped and lifted with bent grasping forceps, and by bending the tip of a stapler, the surgeon resected the affected portion of the bilateral lungs. In this approach, there is one incision, no intercostal nerve damage and bilateral surgery can be performed in the same procedure; therefore, the technique may have the benefit of lesser invasiveness for the patient. Furthermore, a detailed comparison of subxiphoid uniportal bilateral lung wedge resection with the one-stage lateral intercostal approach with a larger subject sample is needed.

In recent years, uniportal video-assisted thoracoscopic surgery, which performs all surgical procedures from 1 wound, has been spreading for the purpose of performing less invasive surgery. The uniportal surgery requires a device because it interferes with instruments, but is a surgical technique that is cosmetically excellent and can be expected to reduce postoperative pain. This new minimally invasive surgical technique is now widely spread, especially in Asia and Europe. In addition, uniportal surgery using the subxiphoid approach has attracted attention. This method has an advantage that intercostal neuropathy does not occur because it does not pass through the intercostal space, and is a useful method for patients. These uniportal surgery is expected to be further developed as a new minimally invasive surgery. In the future, it is necessary to develop more operable devices and instruments, including robot systems, and to prove the usefulness of uniportal surgery.

OBJECTIVE: We compared post-thoracotomy pain syndrome (PTPS) incidence in patients who underwent uniportal or multiportal video-assisted thoracoscopic surgery (VATS). METHODS: We included 223 patients who underwent either uniportal or multiportal VATS between January 2017 and October 2018 (pulmonary lobectomies and pulmonary segmentectomies-uniportal: n=19, multiportal: n=133; wedge lung resections-uniportal: n=16, multiportal: n=55). We retrospectively studied incidences of PTPS in all subgroups. RESULTS: Incidences of PTPS were significantly less for uniportal procedures for both the pulmonary lobectomy/segmentectomy group (P=0.024) and the wedge lung resection group (P=0.0315) than for multiportal procedures. CONCLUSION: Patients who underwent uniportal VATS procedures had lower incidences of PTPS than the multiportal VATS group. The uniportal VATS approach is therefore beneficial for patients.

OBJECTIVE: Precise prediction of postoperative pulmonary function is extremely important for accurately evaluating the risk of perioperative morbidity and mortality after major surgery for lung cancer. This study aimed to compare the accuracy of a single-photon emission computed tomography/computed tomography (SPECT/CT) method that we recently developed for predicting postoperative pulmonary function versus the accuracy of both the conventional simplified calculating (SC) method and the method using planar images of lung perfusion scintigraphy. METHODS: The relationship between the postoperative observed % values of the forced expiratory volume in 1 second (FEV1) or diffusing capacity for carbon monoxide (DLCO or DLCO') and the % predicted postoperative (%ppo) values of FEV1, DLCO, or DLCO' calculated by the three methods were analyzed in 30 consecutive patients with lung cancer undergoing lobectomy. RESULTS: The relationship between the postoperative observed % values and %ppo values calculated by the three methods exhibited a strong correlation (Pearson r>0.8, two-tailed p<0.0001). The limits of agreement between the postoperative % values and %ppo values did not differ among the three methods. The absolute values of the differences between the postoperative % values and %ppo values for FEV1 and DLCO' were comparable among the three methods, whereas those for DLCO of SPECT/CT were significantly higher than those of the planar method. Conversely, in patients with preoperative %DLCO' of <80% predicted, the absolute values of the differences between the postoperative %DLCO' and %ppoDLCO' of SPECT/CT tended to be smaller than those of the SC and planar methods. CONCLUSION: The accuracy of SPECT/CT for predicting postoperative pulmonary function is comparable with that of conventional methods in most cases, other than in some patients with diffusion impairment.

Background: This study aimed to investigate the initial results of an endoscopic surgical approach for the treatment of intramediastinal ectopic parathyroid adenoma and to evaluate the effectiveness of a single-incision resection using the subxiphoid approach. Methods: Five cases of patients (1.89%) were diagnosed with ectopic mediastinal parathyroid tumor and underwent resection from 2008 to 2017 in Fujita Health University Hospital. They were retrospectively analyzed. Results: Four patients underwent single-port mediastinal tumor resection using the subxiphoid approach and 1 patient underwent multi-port mediastinal tumor resection using the lateral thoracic approach. The operation time was 134±83.52 min, and the amount of blood loss was 81.8±173.41 mL. The rate of conversion to thoracotomy was 0%, and no intraoperative or postoperative complications were observed. The amount of postoperative oral analgesics was 112.83±209.12 tablets, and their administration period was 561.6±1,229.5 days. The length of hospital stay was 4±2.35 days, and the duration of chest tube drainage was 1.33±1.95 days. The patient who underwent multi-port mediastinal tumor resection using the lateral thoracic approach reported postoperative pain. Serum calcium levels decreased from 10.56±1.52 mg/dL preoperatively to 8.96±0.5 mg/dL postoperatively, and serum phosphorous levels increased from 2.84±0.42 mg/dL preoperatively to 3.6±0.51 mg/dL postoperatively. Intact-PTH hormone levels decreased from 221±169.84 pg/dL preoperatively to 70.2±44.28 pg/dL postoperatively. No recurrence of hyperparathyroidism has been observed in any patient. Conclusions: The single-incision mediastinal tumor resection via the subxiphoid approach, without going through the intercostal space, is considered as a useful endoscopic surgical approach for the treatment of mediastinal ectopic parathyroid adenomas due to the limited occurrence of post-thoracotomy pain syndrome and the superior esthetic outcomes associated with the procedure as compared to thoracotomy and median sternotomy.