Matsuura Akihiro

(松浦晃洋)

Profile Information

Affiliation: School of Medicine, Faculty of Medicine, Fujita Health University

Degree: 博士(医学）

J-GLOBAL ID: 200901081481766743
researchmap Member ID: 5000025202

学園の研究の統括を行なっています。放射光による病理診断を実施しています

お知らせ
大学の研究統括部になりました。よろしくお願いいたします

Research Areas

Nanotechnology/Materials / Nanobioscience / Synchrotron-radiation based diagnosis

Research History

Apr, 2019 - Present

Professor, Research general headquarters, Fujita Health University
2000 - Present

Professor, School of Medicine, Fujita Health University
1996 - 1999

Associate Professor, School of Medicine, Sapporo Medical University
1991 - 1996

Assistant Professor, School of Medicine, Sapporo Medical University
1988 - 1991

Research Associate, School of Medicine, Sapporo Medical University

Committee Memberships

Oct, 2015 - Present

委員, 藤田保健衛生大学研究戦略委員会
Oct, 2015 - Present

委員, 藤田保健衛生大学研究マネジメント委員会
Apr, 2015 - Present

委員長, 藤田保健衛生大学医学研究倫理審査委員会
2015 - Present

Executive secretary, International Society of Trace Element Research in Humans
2012 - Present

幹事, ウイルソン病研究会

Papers

207

Diagnostic copper imaging of Wilson disease by synchrotron radiation X-ray fluorescence technique

Matsura A, Kinebuchi M

Proceedings of the 106th Annunal Meeting of the Japanese Society of Pathology, 106 2D3, May, 2017 Peer-reviewed
Precise diagnosis of pre symptomatic Wilson disease by integrating synchrotron X-ray

Matsuura A, Kinebuchi M

J Trace Elem Med Biol, 41S 34, 2017 Peer-reviewed
Current status of Wilson disease in Japan 2017: challenges toward precise diagnosis by synchrotron-generated X-ray

Matsuura A, Kinebuchi M

Photon Factory Activity Report, 2017 Peer-reviewed
Medical application of synchrotron radiation: high precision diagnosis of diseases due to specific elements abnormality

Matsuura A, Kinebuchi M

KEK Synchrotron radiation CDR ver.3, 2017 Peer-reviewed
One autopsy case of Wilson's disease suspected of cardiac death while waiting for transplantation of brain death

Tanaka K, Kyo S, Oomori Y, Tanaka S, Matsuura A, Kinebuchi M

Wilson disease Kenkyu-kai-shi, 20 7, 2016
Diagnostic copper imaging of pathology examination by synchrotron-generated X-ray: basic principal and application to Wilson disease

Matsuura A, Kinebuchi M

Proceedings of International Copper Research Meeting, 10, 2016 Peer-reviewed
Trial of ultra high-resolution imaging on biological specimens by nanomeam X-ray fluorescence.

Matsura A, Kinebuchi M

SPring-8/SACLA Research Report, Epub ahead, 2016 Peer-reviewed
Wilson disease in Japan: current status and challenge to copper detection by synchrotron X-ray.

Matsura A, Kinebuchi M

Proceedings of the 105th Annunal Meeting of the Japanese Society of Pathology, 348, 2016 Peer-reviewed
Development of diagnostic method by establishment of Function of tumor-associated granulomatosis

Kinebuchi M, Matsuura A, Kondo M

Jpn J Dermatol, 126(5) 953, 2016 Peer-reviewed
Clinical Guideline of Wilson disease 2015

Matsura akihiro

29(2) 63-119, Dec, 2015 Peer-reviewed
Challenge to copper detection in Wilson disease by synchrotron generated X-ray

Matsura A, Kinebuchi M

J. Trace Elem. Med. Biol., 32S 25-25, Oct, 2015 Peer-reviewed
Calcium-overloaded sympathetic preganglionic neurons in a case of severe sepsis with anorexia nervosa.

Miyuki Kinebuchi, Akihiro Matsuura

Acute medicine & surgery, 2(3) 169-175, Jul, 2015 Peer-reviewed

Aim: We aimed to show the status of intracellular elements in sympathetic preganglionic neurons in an autopsy case of a 55-year-old woman with severe sepsis and cardiac dysfunction with anorexia nervosa. Methods: Our methods include a case report and pathological examinations of autopsied tissues using synchrotron-generated microbeam X-ray fluorescence analysis. Results: A case report of severe sepsis and myocardial dysfunction. The patient had sudden short cardiac arrest without arrhythmia and sequelae, and echocardiogram showed negative inotropic change. The X-ray fluorescence analysis of autopsied tissues indicated an unusually high concentration of cytosolic calcium in sympathetic preganglionic neurons. However, there were no significant pathological findings of damage in the heart or the cardiovascular autonomic nuclei in the central nervous system. Conclusion: The data indicate that dysfunction of the sympathetic preganglionic neurons exists in a patient of severe sepsis and cardiac dysfunction with anorexia nervosa.
Ultra high-resolution copper imaging by the nanobeam X-ray fluorescence.

Matsuura A, Kinebuchi M

Proceedings of X-ray Imaging Optics, 13 25, 2015 Peer-reviewedInvited
Detector Setting of X-ray Fluorescence Analysis for Histological Specimens

Matsura A, Kinebuchi M

Photon Factory Activity Report, 2014#32(B) 30, 2015 Peer-reviewed
Pathological diagnosis of Wilson disease

Matsura akihiro

Wilson disease guideline 2015 Kodama H Ed, 2015 Peer-reviewedInvited
Ultra high resolution imaging of copper accumulation by the nano beam X-ray fluorescence

Matsura A, Kinebuchi M

SPring-8/SACLA Research Report, 13 25, 2015 Peer-reviewedInvited
Clinical research and ethical considerations

Matsuura A

The Japanese Journal of Rehabilitation Medicine, 51 634-639, 2014 Peer-reviewed
Ultra high-resolution imaging of copper accumulation by nano beam X-ray fluorescence.

Matsura A, Kinebuchi M

SPring-8 experiment summary report support project 2013, Y2013(Part B) 31-31, 2014 Peer-reviewed
Refinement of X-ray dluorescence analysis of biological specimens.

Matsuura A, Kinebuchi M

Photon Factory activity report 2013, 31 315, 2014
Synchrotron X-ray fluorescence microscopy of biological specimens: Basic instrument arrangement and a trial measurement.

Matsura A, Kinebuchi M

Photon Factory activity report, 31(309) 309, 2014 Peer-reviewed
New age pathologists with the synchrotron: How to apply the synchrotron-based X-ray fluorescence analysis to pathological diagnosis

Matsura A, Kinebuchi M

J Nanomed Nanotechnol, 5 121, 2014 Peer-reviewed
Copper imaging by microbeam X-ray fluorescence analysis for diagnosis of presymptomatic Wilson disease.

Matsuura A, Kinebuchi M, Terada Y

SPring-8 experiment summary report support project 2012 (2012B1002), 2012(B) 1002-1002, 2013 Peer-reviewed
Tissue element imaging by third generation synchrotron radiation - Application to genetic disease analysis

Matsuura A, Kinebuchi M

Spring-8 Safety Assurance Association Sixth Report, 6 1, 2012 Peer-reviewedInvited
Correlation of histological grade and copper accumulation in Wilsonian hepatitis-analysis by tissue element imaging.

Matsuura A, Kinebuchi M, Terada Y

SPring-8 Research Report of Nanotechnology Support Peoject, H23(B) 86-87, 2012 Peer-reviewed
Clinicopathological significance of trace elements in livers of with acute liver failure due to copper.

Matsuura A, Kinebuchi M, Terada Y

SPring-8 Research Report of Nanotechnology Support Project, H23(A) 85-86, 2012 Peer-reviewed
倫理委員会に関する諸問題：グループ発表

松浦晃洋

メデカルエシックス44、医学系大学倫理委員会連絡会議編, 108-128, 2012
倫理委員会に関する諸問題：グループディスカッション５班迅速審査

松浦晃洋

メデカルエシックス44、医学系大学倫理委員会連絡会議編, 97-99, 2012
倫理委員会に関する諸問題：G「迅速審査」

松浦晃洋

メデカルエシックス44医学系大学倫理委員会連絡会議編, 75-81, 2012
Histological grading of Wilsonian hepatitis and copper localization

Matsuura A, Kinebuchi M, Terada Y

Spring-8 Research report of nanotechnology support project 2011, 85-86, 2011 Peer-reviewed
Trace elements in the livers of Wilson disease with acute hepatic failure

Matsuura A

Spring-8 Research report of nanotechnology support project 2011(2011B1715), 2011A 50-51, 2011 Peer-reviewed
Topological distribution of trace elements in human neural tissues and its pathologic change

Matsuura A, Kinebuchi M, Terada Y

SPring-8 Result report of nanotechnology support project, 2010B 47-48, 2010 Peer-reviewed
Pathological analysis of trace elements in spinal cord by high-resolution X-ray mapping

Matsuura A, Kinebuchi M, Terada Y

SPring-8 User Experiment Report, 2010A 25, 2010 Peer-reviewed
Characteristic features of tissue element in presymptomatic patients with Wilson disease

Matsuura A, Kinebuchi M, Terada Y

SPring-8 User Experiment Report 2010, 2010A 22-23, 2010 Peer-reviewed
Histopathologic basis of neuronal tissues by microbeam XRF analysis

Matsuura A

Result report of medical bio EX proposal. 2009B, 2009B 170-171, 2010 Peer-reviewed
Uneven distribution of elements in the liver associated with development of hepatic Wilson disease using high-resolution tissue element imaging of microbeam X-ray fluorescence analysis

Matsuura A, Kinebuchi M, Terada Y

SPring-8 Result report of medical bio EX proposal. 2010A, 2010A 166-167, 2010 Peer-reviewed
Analysis of elementals distributions in a degenerative cell of central nervous system using high-resolution tissue elements imaging of microbeam X-ray fluorescence analysis

Matsuura A

Result report of medical bio EX proposal. 2010A, 2010A 168-169, 2010 Peer-reviewed
Early changes of Wilson disease by tissue element imaging

Matsuura A

Result report of nanotechnology support project. 2010B, 2010B 1700-1701, 2010 Peer-reviewed
Diagnosis and pathological clarification of Wilson 's disease using high - resolution X-ray fluorescence analysis

Matsuura A, Kinebuchi M, Mizoguchi Y, Kamada Y

Journal of Japanese Pathology Association, 98 248, 2009 Peer-reviewed
Histopathological analysis of gastrointestinal injury by trace elementfs

Matsuura A, Kinebuchi M, Terada Y

Result Report of Medical Bio EX Proposal., 2009A 168-169, 2009 Peer-reviewed
Histopathological analysis of gastrointestinal injury by trace elements

Matsuura A, t

Result report of medical bio EX proposal. 2009A, 168-169, 2009
Evaluation of the therapeutic effect of a patient with intractable hepatitis associated with Wilson disease by the high resolution X-ray fluorescence mapping of trace elements

Matsuura A

Result report of nanotechnology support project. 2008B, 102-103, 2009
Histopathology of Wilson Disease ? Is the definitive diagnosis possible?

Matsuura A

Wilson Disease Study Bulletin, 13 12, 2009
Quantitative analysis of liver copper by the tissue element imaging

Matsuura A

SPring-8 Result report of medical nanotechnology support subject. 2009A, 2009A 170-171, 2009 Peer-reviewed
Analysis of the elemental content and distribution in normal and patients with Wilson disease with high-resolution tissue element imaging by microbeam X-ray fluorescence analysis

Matsuura A

Result report of medical bio EX proposal. 2009A, 2009A 168-169, 2009 Peer-reviewed
The signaling adaptor protein CD3 zeta is a negative regulator of dendrite development in young neurons

Stephane J. Baudouin, Julie Angibaud, Gildas Loussouarn, Virginie Bonnamain, Akihiro Matsuura, Miyuki Kinebuchi, Philippe Naveilhan, Helene Boudin

MOLECULAR BIOLOGY OF THE CELL, 19(6) 2444-2456, Jun, 2008 Peer-reviewed
Evaluation of the therapeutic effect of a patient with intractable hepatitis associated with Wilson disease by the high resolution X-ray fluorescence mapping of trace elements

Matsuura A, Kinebuchi M, Terada Y

SPring-8 Result report of nanotechnology support project, 2008B 102-103, 2008 Peer-reviewed
Early diagnosis of Wilson's disease by application of gene mutation analysis and fluorescent X-ray analysis

Matsuura A, Kinebuchi M, Mizoguchi Y, Ye S, Kamada Y

Proceedings of Annunal Meeting of the Japanese Society of Pathology, 97 255, 2008 Peer-reviewed
Histopathological dissection of an inherited disorder of copper deficiency by microbeam X-ray fluorescence analysis

Matsuura A, Kinebuchi M, Terada Y

SPring-8 Result report of medical bio EX proposal, 2008A 66-67, 2008 Peer-reviewed
Evaluation of therapeutic effect of Wilson disease by microbeam X-ray fluorescence analysis

Matsuura A, Kinebuchi M, Terada Y

SPring-8 Result report of nanotechnology support project, 2008A 92-93, 2008 Peer-reviewed
Histopathological analysis of renal injury by trace elements

Matsuura A, Kinebuchi M, Terada Y

SPring-8 Result report of medical bio EX proposal, 2008B 68-70, 2008 Peer-reviewed

Books and Other Publications

小児の栄養消化器肝臓病診療ガイドライン･指針

松浦晃洋 (Role: Contributor, Wilson病診療ガイドライン)

診断と治療社, Oct, 2015 (ISBN: 9784787820563)
器官病理学

笠原正典, 佐藤昇史

南山堂, 2013
医科免疫学改訂第６版

菊地浩吉, 上出利光

南江堂, 2009
病態病理学吉木敬、菊地浩吉、石倉浩編

matsura akihiro

2004
Pathology, Stevens and Lowe (translate to Japanese)

Matsura akihiro (Role: Joint translator)

2002

Presentations

Clinical evaluation of copper-histidine treatment for a genetic disease caused by a copper-transporter deficiency using synchrotron radiation-generated X-ray fluorescence

Kinebuchi M, Matsuura A

The 24th Congress of the International Commission for Optics, Aug 22, 2017
O-4 Precise diagnosis of pre symptomatic Wilson disease by integrating synchrotron X-ray

Matsuura A, Kinebuchi M

International Symposium of Trace Elements in Man and Animals, Jun 29, 2017
Where are the limits of standard treatment with histidine copper (interim report)

Matsuura A, Kinebuchi M

21th Wilson disease researchmeetig, May 20, 2017
Diagnostic copper imaging of pathology examination by synchrotron-generated X-ray: basic principle and application to Wilson disease

Matsura A, Kinebuchi M

10th International Copper Meeting, Sep 25, 2016
Wilson disease in Japan: current status and challenge to copper detection by synchrotron X-ray

Matsuura A, Kinebuchi M

The 105th Annual Meeting of the Japanese Society of Pathology, May 13, 2016

Teaching Experience

Graduiertenkolleg Molekularbiologische Analyse pathophysiologischer Prozesse und Abteilung Immunogenetik (Medizinische Fakultaet der Georg-August-Universitaet Goettingen)
免疫 (名古屋大学医学部大学院)
免疫 (北海道大学免疫科学研究所大学院)
膠原病 (藤田保険衛生大学)
倫理 (藤田保険衛生大学)

Professional Memberships

Research Projects

臓器の炎症におけるCD1dの病態生理学的意義

基盤研究B, 日本学術振興会, Apr, 2001 - Mar, 2004

松浦晃洋
加齢に伴うNKT細胞のCD1認識能の変化と病理学的意義

研究助成, 北海道老年医学研究境界, Apr, 1999 - Mar, 2000

松浦晃洋
NKT細胞の加齢における変化と自己免疫性肝炎発症に関する研究

研究助成, 北海道老年医学研究会, Apr, 1998 - Mar, 1999

松浦晃洋
新しい抗原提示分子CD1d抗原の発現と生体内抗原提示能

医学教育研究助成, 札幌医科大学学術振興会, Apr, 1997 - Mar, 1998

松浦晃洋
ストレス蛋白質に対するT細胞応答の分子機構

一般研究B, 文部省, Apr, 1995 - Mar, 1998

佐藤昇志

教育内容・方法の工夫（授業評価等を含む）

件名（英語）

病態病理実習（M4)におけるe-learningの導入・利用

開始年月日（英語）

2011

終了年月日（英語）

2013

概要（英語）

サーバーを介した画像情報の提供。自分で操作するバーチャルスライド方式を導入した。８コマ分

作成した教科書、教材、参考書

件名（英語）

器官病理学　

終了年月日（英語）

2013

概要（英語）

M3に病理学を再導入し、新たに基礎と臨床をつなぐ臓器毎の資料を作成。
件名（英語）

医科免疫学改訂第6版

終了年月日（英語）

2009

概要（英語）

講義毎に漸次増やしている。一部はそれに付加して教科書（器官病理学）の原稿とした。

教育方法・教育実践に関する発表、講演等

件名（英語）

倫理委員会の教育講演会および大学院選択式セミナー

開始年月日（英語）

2009

終了年月日（英語）

2013

概要（英語）

「研究に関する倫理」について講演・セミナーを行った。年2回。
件名（英語）

大学院講義

開始年月日（英語）

2008

終了年月日（英語）

2013

概要（英語）

大学院講義で「発がんの生物学」のセミナーを行った。年１回、腫瘍学基盤先端セミナーで座長を努めた

その他教育活動上特記すべき事項

件名（英語）

大学院がんプロコースの立ち上げとコーディネート

開始年月日（英語）

2009

終了年月日（英語）

2013

概要（英語）

大学院腫瘍学セミナー（腫瘍学基盤先端セミナー）を世話人としてオーガナイズ。年5回、がんセミナー（発がんの分子生物学・がんの生物学的基盤）担当　年1回。
件名（英語）

総研大学院大学学位審査外部委員

開始年月日（英語）

2009

終了年月日（英語）

2013

概要（英語）

Reviewを行う
件名（英語）

Pathology International(雑誌)刊行委員

開始年月日（英語）

2009

終了年月日（英語）

2013

概要（英語）

Reviewを行う

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