Curriculum Vitaes
Profile Information
- Affiliation
- School of Medicine Faculty of Medicine, Fujita Health University
- Degree
- 医学博士(藤田保健衛生大学)
- J-GLOBAL ID
- 200901003157012581
- researchmap Member ID
- 1000102561
Research Areas
1Papers
102-
BMC Gastroenterology, 22(1), Dec, 2022
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Heterotopic ossification in primary rectal cancer with squamous cell carcinoma-like differentiation.Fujita medical journal, 8(4) 134-138, Nov, 2022OBJECTIVES: Heterotopic ossification (HO), which occurs when bone tissue forms outside the skeleton, is extremely rare in rectal cancer. Adenocarcinoma is the histological type of all reported primary colorectal cancers with HO. However, in the present case, we observed areas of adenocarcinoma with squamous cell carcinoma-like differentiation. Here we conducted histopathological and immunohistochemical analyses to identify the mechanisms of HO development, to differentiate between adenocarcinoma and squamous cell carcinoma-like phenotypes, and to understand the associated prognostic implications. CASE REPORT: A 62-year-old woman was admitted to our hospital with symptoms of intermittent hematochezia without abdominal pain. Colonoscopy revealed stenosis with a protuberant mass in the rectum. Abdominopelvic contrast-enhanced computed tomography showed irregular wall thickness of the rectum, multiple lymph node metastases, and liver metastases. The rectal tumor exhibited calcified deposits with marked hyperintensity. We then performed Hartmann's operation and D3 lymph node resection. The biopsy specimen revealed tubular and solid adenocarcinoma nests and squamous carcinoma-like components over a necrotic extent without secreted mucin. She received chemotherapy (mFOLFOX6 with bevacizumab) as the first option and is alive 5 months after surgery. CONCLUSION: To the best of our knowledge, this is the first case of heterotopic ossification in a primary rectal cancer with squamous cell carcinoma-like differentiation that was surgically resected. This case suggests that BMP-2 transformed fibroblasts and pluripotent stem cells into osteocytes. We conclude that the squamous cell carcinoma-like lesion was squamous metaplasia of adenocarcinoma.
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日本消化器外科学会雑誌, 55(Suppl.2) 291-291, Oct, 2022
Misc.
454-
日本臨床外科学会雑誌, 74(増刊) 449-449, Oct, 2013
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日本外科学会雑誌, 114(2) 487-487, Mar 5, 2013
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Hindawi Publishing Corporation Case Reprts in Hepatolgy, 2013
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World Journal of Gastrointestina Surgery, 5(6) 173-177, 2013AIM: To study our novel caudal approach laparoscopic posterior-sectionectomy with parenchymal transection prior to mobilization under laparoscopy-specific view. METHODS: Points of the procedure are: (1) Patients are put in left lateral position and posterior sector is not mobilized; (2) Glissonian pedicle of the sector is encircled and clamped extra-hepatically and divided afterward during the transection; (3) Dissection of inferior vena cava (IVC) anterior wall behind the liver is started from caudal. Simultaneously, liver transection is performed to search right hepatic vein (RHV) from caudal; (4) Liver transection proceeds to the bifurcation of the vessels from caudal to cranial, exposing the surfaces of IVC and RHV. Since the remnant liver sinks down, the cutting surface is well-opend; and (5) After the completion of transection, dissection of the resected liver from retroperitoneum is easily performed using the gravity. This approach was performed for a 63 years old woman with liver metastasis close to RHV. RESULTS: RHV exposure is required for R0 resection of the lesion. Although the cutting plane is horizontal in supine position and the gravity obstructs the exposure in the small subphrenic space, the use of specific characteristics of laparoscopic hepatectomy, such as the good vision for the dorsal part of the liver and IVC and facilitated dissection using the gravity with the patient positioning, made the complete RHV exposure during the liver transection easy to perform. The operation time was 341 min and operative blood loss was 1356 mL. Her postoperative hospital stay was uneventfull and she is well without any signs of recurrences 14 mo after surgery. CONCLUSION: The new procedure is feasible and useful for the patients with tumors close to RHV and the need of the exposure of RHV.
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World Journal of Hepatology, 5(9) 487-495, 2013
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日本内視鏡外科学会雑誌, 17(7) 254-254, Dec, 2012
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日本臨床外科学会雑誌, 73(増刊) 691-691, Oct, 2012
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日本肝胆膵外科学会・学術集会プログラム・抄録集, 24回 199-199, May, 2012
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日本外科学会雑誌, 113(臨増2) 680-680, Mar, 2012
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Japanese Journal of Gastroenterological Surgery, 45(11) 1112-1120, 2012
Presentations
91Research Projects
3-
Grants-in-Aid for Scientific Research, Japan Society for the Promotion of Science, 2004 - 2005
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Grants-in-Aid for Scientific Research, Japan Society for the Promotion of Science, 2001 - 2002
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Grants-in-Aid for Scientific Research, Japan Society for the Promotion of Science, 1999 - 2000