Tsuneo Imai

Using anti-S100α and S100β antibodies without any cross reactivity which were purified by affinity chromatography, an immunohistochemicalstudy was conducted on 72 benign breast lesions (from 34 cases of mastopathy and38 cases of fibroadenoma) and 72 malignant breast lesions (invasive ductal carcinoma). Both S100α- and S100β-positive cells occupied more than 30% of proliferation in all the benign lesions. On the other hand, malignant lesion with S100α-positive cells occupied more than 30% of proliferation was confirmed in 70 cases (97.2%), but the lesion with S100β-positive cells in more than 30% of occupation rate was found only in 3 cases (4.2%). These findings indicate that there is a decreasing tendency of S100β-positive cells in breastcancers.<br> We think that this exploration using such very specific antibodies capable of clarifying hidden findings from usual antibody tests can be an adjuvantexamination for breast lesions which present difficulty in differential diagnosis only by HE staining.

From 1979 through 1992, we have conducted operations for differentiated thyroid carcinoma in 392 cases, 18 of which were under the age of 20. As in the case of adults, the same basic surgical approach was used for the young patients: 1) total thyroidectomy, 2) bilateral lymph node dissection, and 3) parathyroid autotransplantation. We attempted to determine the strengths and weaknesses of our operative approach by comparing for diameter of neoplasms, lymph node metastases and the like with adults, including the Quality of Life in the postoperative course. Tumor diameter was more than t2 in 80% of the cases, and in 60% of adults. Lymph node metastases were found in about 90% of the patients, and in 76% of the adults. Evidence of progressive carcinoma was found operatively in more young persons than adults, but there was no recurrence in all 18 cases. Postoperative complications included only a mildly lowered parathyroid function in one case and postoperative cheloid in 3 cases. No problem whatsover was noted in growth or development of the patients less than 10 years of age; 3 females who had come of age had children. Thus our surgical approach is considered appropriate, and promises sufficient radicality and favorable postoperative course.