東端晃

研究者氏名	東端晃
	ヒガシバタアキラ
URL
所属	国立研究開発法人宇宙航空研究開発機構
部署	有人宇宙技術部門きぼう利用センター
職名	技術領域主幹
J-Global ID	200901002313084710

研究分野

ライフサイエンス / 分子生物学 /

受賞

2017年9月

日本宇宙生物科学会, 日本宇宙生物科学会学会賞
東端晃

論文

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Comparative Analysis of Muscle Atrophy During Spaceflight, Nutritional Deficiency and Disuse in the Nematode Caenorhabditis elegans.

Ban-Seok Kim Alfredo V Alcantara Jr Je-Hyun Moon Atsushi Higashitani Nahoko Higashitani Timothy Etheridge Nathaniel J Szewczyk Colleen S Deane Christopher J Gaffney Akira Higashibata Toko Hashizume Kyoung-Hye Yoon Jin I Lee

International journal of molecular sciences 24(16) 2023年8月

While spaceflight is becoming more common than before, the hazards spaceflight and space microgravity pose to the human body remain relatively unexplored. Astronauts experience muscle atrophy after spaceflight, but the exact reasons for this and s...

Reactive oxygen species upregulate expression of muscle atrophy-associated ubiquitin ligase Cbl-b in rat L6 skeletal muscle cells

Takayuki Uchida Yoshihiro Sakashita Kanako Kitahata Yui Yamashita Chisato Tomida Yuki Kimori Akio Komatsu Katsuya Hirasaka Ayako Ohno Reiko Nakao Atsushi Higashitani Akira Higashibata Noriaki Ishioka Toru Shimazu Takeshi Kobayashi Yuushi Okumura Inho Choi Motoko Oarada Edward M. Mills Shigetada Teshima-Kondo Shin’ichi Takeda Eiji Tanaka Keiji Tanaka Masahiro Sokabe Takeshi Nikawa

American Journal of Physiology - Cell Physiology 314(6) C721-C731 2018年6月 [査読有り]

Unloading-mediated muscle atrophy is associated with increased reactive oxygen species (ROS) production. We previously demonstrated that elevated ubiquitin ligase casitas B-lineage lymphoma-b (Cbl-b) resulted in the loss of muscle volume (Nakao R,...

Root-tip-mediated inhibition of hydrotropism is accompanied with the suppression of asymmetric expression of auxin-inducible genes in response to moisture gradients in cucumber roots

Nobuharu Fujii Sachiko Miyabayashi Tomoki Sugita Akie Kobayashi Chiaki Yamazaki Yutaka Miyazawa Motoshi Kamada Haruo Kasahara Ikuko Osada Toru Shimazu Yasuo Fusejima Akira Higashibata Takashi Yamazaki Noriaki Ishioka Hideyuki Takahashi

PLoS ONE 13(1) e0189827 2018年1月 [査読有り]

In cucumber seedlings, gravitropism interferes with hydrotropism, which results in the nearly complete inhibition of hydrotropism under stationary conditions. However, hydrotropic responses are induced when the gravitropic response in the root is ...

Persistence of plant hormone levels in rice shoots grown under microgravity conditions in space: its relationship to maintenance of shoot growth

Kazuyuki Wakabayashi Kouichi Soga Takayuki Hoson Toshihisa Kotake Mikiko Kojima Hitoshi Sakakibara Takashi Yamazaki Akira Higashibata Noriaki Ishioka Toru Shimazu Motoshi Kamada

PHYSIOLOGIA PLANTARUM 161(2) 285-293 2017年10月 [査読有り]

We investigated the effects of microgravity environment on growth and plant hormone levels in dark-grown rice shoots cultivated in artificial 1 g and microgravity conditions on the International Space Station (ISS). Growth of microgravity-grown sh...

Gravitropism interferes with hydrotropism via counteracting auxin dynamics in cucumber roots: clinorotation and spaceflight experiments

Keita Morohashi Miki Okamoto Chiaki Yamazaki Nobuharu Fujii Yutaka Miyazawa Motoshi Kamada Haruo Kasahara Ikuko Osada Toru Shimazu Yasuo Fusejima Akira Higashibata Takashi Yamazaki Noriaki Ishioka Akie Kobayashi Hideyuki Takahashi

NEW PHYTOLOGIST 215(4) 1476-1489 2017年9月 [査読有り]

Roots of land plants show gravitropism and hydrotropism in response to gravity and moisture gradients, respectively, for controlling their growth orientation. Gravitropism interferes with hydrotropism, although the mechanistic aspects are poorly u...