研究者業績

今井一洋

イマイカズヒロ (Kazuhiro Imai)

基本情報

所属: 武蔵野大学薬学研究所薬学研究所客員教授,名誉教授（東京大学）

学位: Ph.D.
Master of pharmaceutical Sciences

J-GLOBAL ID: 200901058703864038
researchmap会員ID: 1000013291

研究キーワード

2

研究分野

1

ライフサイエンス / 薬系分析、物理化学 /

経歴

11

2012年 - 現在

武蔵野大学客員教授
2003年 - 現在

- 武蔵野大学教授
2003年 - 2012年

武蔵野大学教授
1993年 - 2003年

東京大学教授
1993年 - 2003年

東京大学

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学歴

4

委員歴

11

1998年 - 1999年

クロマトグラフィー科学会会長
1999年

日本薬理学会評議員、選考委員
1998年

Academia Iberoamericana de Pharmacia 会員
1995年 - 1997年

国際薬学連合薬科学部会代議員
1991年 - 1994年

日本臨床化学会評議員

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受賞

7

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論文

2

Alteration of intracellular secretory acute phase response proteins expressed in human hepatocyte induced by exposure with interleukin-6 Liquid chromatographic separation of proteins derivatized with a fluorogenic reagent at cysteinyl residues on

K. Nakata, R. Saitoh, J. Amano, A. Koshiyama, T. Ichibangase, N. Murao, K. Ohta, Y. Aso, M. Ishigai, K. Imai

Cytokine 2012年9月査読有り
A toxicoproteomic study on cardioproteactive effects of pre-administration of docetaxel in a mouse model of adriamycin-induced cardiotoxicity

Biochem. Pharm. 2010年

MISC

246

The Effects of Spacer Length on the Fluorescence Quantum Yields of the Benzofurazan Compounds Bearing a Donor-acceptor System.

Luminescence 17, 11-14 2002年
An Automated Analyzer for Methylated Arginines in Rat Plasma by High-Performance Liquid Chromatography with Post-Column Fluorescence Reaction.

Analyst 127, 54-59 2002年
A fluorogenic reagent, 4-mercapto-7-methylthio-2,1,3-benzoxadiazole for carboxylic acids, designed by prediction of the fluorescence intensity

S. Uchiyama, T. Santa, K. Imai

Analytical Chemistry 73(10) 2165-2170 2001年5月15日
BF3-methanol as a cyclization/cleavage/conversion reagent for suppression of amino acid racemization in Edman sequencing and L-configuration determination method

Natsuko Okiyama, Tomofumi Santa, Akira Toriba, Kazuhiro Imai

Analytica Chimica Acta 429(2) 293-300 2001年2月23日
Determination of Bradykinin in Rat Urine by Coupled-Column High Pressure Liquid Chromatography with Precolumn Derivatization with a Water-Soluble Fluorogenic Reagent.

Anal. Biochem. 297, 52-59 2001年
Deductive Prediction of Precision and Detection Limit in Bioluminescent Measurement Systems.

Anal.Chim. Acta. 441, 243-248 2001年
Oxidative Stress in the Absense of Inflammation in a Mouse Model for Hepatitis C Virus-associated Hepatocarcinogenesis.

Cancer Res. 61, 4365-4370 2001年
A Study of Chiral Recognition for NBD-Deribatives on a Pirkle-Type Chiral Stationary Phase.

Biomed. Chromatogr. 15, 227-234 2001年
Simultaneous Determination of D-lactic Acid and 3-Hydroxybutyric Acid in Rat Plasma Using a Colomn-Switcing HPLC with Fluorescent Derivatization with 4-Nitro-7-piperazino-2, 1, 3-benzoxadiazole (NBD-PZ)

Biomed. Chromatogr. 15, 189-195 2001年
A Fluorogenic Reagent, 4-Mercapto-7-methylthio-2, 1, 3-benzoxadiazole for Carboxylic Acids, Designed by Prediction of the Fluorescence Intensity.

Anal. Chem. 73, 2165-2170 2001年
A Method for the Measurement of Catechol-O-Methyltransferase Activity Using Norepinephrine, an Endogenous Substrate.

Analyst 126, 637-640 2001年
A Fluorimetric, Column-Switching HPLC and its Application to an Elimination Study of LLU-α Enantiomers in Rat Plasma

Biomed. Chromatogr. 15, 95-99 2001年
Determination of Catecholamines and their 3-O-Methyl Metabolites in Mouse Plasma.

Biomed. Chromatogr. 15, 41-44 2001年
Localization, Transport, and Uptake of D-Aspatate in the Rat Adrenal and Pituitary Glands.

Arch. Biochem. Biophys. 385, 242-249 2001年
Determination of Bradykinin in Rat Urine by Coupled-Column High Pressure Liquid Chromatography with Precolumn Derivatization with a Water-Soluble Fluorogenic Reagent.

Anal. Biochem. 297, 52-59 2001年
Deductive Prediction of Precision and Detection Limit in Bioluminescent Measurement Systems.

Anal.Chim. Acta. 441, 243-248 2001年
Oxidative Stress in the Absense of Inflammation in a Mouse Model for Hepatitis C Virus-associated Hepatocarcinogenesis.

Cancer Res. 61, 4365-4370 2001年
A Study of Chiral Recognition for NBD-Deribatives on a Pirkle-Type Chiral Stationary Phase.

Biomed. Chromatogr. 15, 227-234 2001年
Simultaneous Determination of D-lactic Acid and 3-Hydroxybutyric Acid in Rat Plasma Using a Colomn-Switcing HPLC with Fluorescent Derivatization with 4-Nitro-7-piperazino-2, 1, 3-benzoxadiazole (NBD-PZ)

Biomed. Chromatogr. 15, 189-195 2001年
A Method for the Measurement of Catechol-O-Methyltransferase Activity Using Norepinephrine, an Endogenous Substrate.

Analyst 126, 637-640 2001年
A Fluorimetric, Column-Switching HPLC and its Application to an Elimination Study of LLU-α Enantiomers in Rat Plasma

Biomed. Chromatogr. 15, 95-99 2001年
Determination of Catecholamines and their 3-O-Methyl Metabolites in Mouse Plasma.

Biomed. Chromatogr. 15, 41-44 2001年
Localization, Transport, and Uptake of D-Aspatate in the Rat Adrenal and Pituitary Glands.

Arch. Biochem. Biophys. 385, 242-249 2001年
D-aspartate in a prolactin-secreting clonal strain of rat pituitary tumor cells (GH(3))

Z Long, JA Lee, T Okamoto, N Nimura, K Imai, H Homma

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 276(3) 1143-1147 2000年10月
Hydroxyprolylserine derivatives JBP923 and JBP485 exhibit the antihepatitis activities after gastrointestinal absorption in rats

KX Liu, Y Kato, T Kaku, F Santa, K Imai, A Yagi, T Ishizu, Y Sugiyama

JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS 294(2) 510-515 2000年8月
社会生活と分析化学医療と分析化学

ぶんせき 12 718-722 2000年
Study on the fluorescent 'on-off' properties of benzofurazan compounds bearing an aromatic substituent group and design of fluorescent 'on-off' derivatization reagents

S Uchiyama, T Santa, K Imai

ANALYST 125(10) 1839-1845 2000年
Ultramicroanalysis of Reducing Carbohydrates by Capillary Electrophoresis with Laser-Induced Fluorescence Detection as 7-Nitro-2,1,3-benzoxadiazole-Tagged N-Methylglycamine Derivatives.

S.Honda, J.Okeda, H.Iwanaga, S.Kawakami, A.Taga, S.Suzuki, K.Imai

Anal. Biochem. 286(1) 99-111 2000年
Production of LLU-α Following an Oral Administration of γ–Tocotrienol or γ-Tocopherol to Rats.

A.Hattori, T.Fukushima, H.Yoshimura, K.Abe, K.Imai

Biol. Pharm. Bull. 23(11) 1395-1397 2000年
An Automatic Analyzer for Catecholamines and Their 3-O-Methyl Metabolites Using a Micro Coulometric Flow Cell as a Postcolumn Reactor for Fluorogenic Reaction

K.Takezawa, M.Tsunoda, N.Watanabe, K.Imai

Anal. Chem. 72(17) 4009-4014 2000年
Semi-empirical PM3 calculations predict the fluorescence quantum yields(φ)of 4-monosubstituted benzofurazan compounds.

S.Uchiyama, T.Santa, N.Okiyama, K.Azuma, K.Imai

J. Chem. Soc., Perkin Trans. (6) 1199-1207 2000年
Development of water-soluble fluorogenic reagents having a 2,1,3-benzoxadiazole structure and their application to the determination of peptides

T Kajiro, T Fukushima, T Santa, K Imai

ANALYST 125(6) 1115-1121 2000年
Detection of 7-N,N-Dimethylaminosulfonyl-4-(2,1,3-benzoxadiazolyl) Carbamoyl Amino Acids Generated by Post-column Desulfuration in the Simultaneous Determination of the Sequence and D/L-Configuration of Peptides using a Fluorogenic Edman Reagent, 7-N,N・・・

A.Toriba, Y.Huang, T.Santa, K.Imai

Anal. Chim. Acta 415(1/2) 57-66 2000年

Detection of 7-N,N-Dimethylaminosulfonyl-4-(2,1,3-benzoxadiazolyl) Carbamoyl Amino Acids Generated by Post-column Desulfuration in the Simultaneous Determination of the Sequence and D/L-Configuration of Peptides using a Fluorogenic Edman Reagent, 7-N,N-Dimethylaminosulfonyl-4-(2,1,3-benzoxadiazolyl) Isothiocyanate
Development of an Amino Acid Sequence and D/L-Configuration Determination Method of Peptide with a New Fluorescence Edman Reagent, 7-Methylthio-4-(2, 1, 3-benzoxadiazolyl)Isothiocyanate

A.Toriba, K.Adzuma, T.Santa, K.Imai

Anal. Chem. 72(4) 732-739 2000年
Occurrence and Determination of a Natriuretic Hormone, 2, 7, 8-Trimethyl-2-(-carboxyethyl)-6-hydroxy Chroman, in Rat Plasma, Urine, and Bile.

A.Hattori, T.Fukushima, K.Imai

Anal. Biochem. 281(2) 209-215 2000年
New Approach for Measurement of Sympathetic Nervous Abnormality in Conscious, Spontaneously Hypertensive Rats.

M.Tsunoda, K.Takezawa, T.Santa, Y.Ina, K.Nagashima, K.Ohmori, S.Kobayashi, K.Imai

Jpn. J. Pharmacol. 83(1) 39-45 2000年
Fluorescent oxidation products derived from DBD-thiocarbamoyl amino acid in the modified Edman sequencing analysis.

Y.Huang, T.Santa, S.Uchiyama, K.Imai

Biomed. Choromatogr. 14(2) 133-136 2000年
Sensitive determination of anandamide in rat brain utilizing a coupled-column HPLC with fluorimetric detectin.

Y.Arai, T.Fukushima, M.Shirao, X.Yang, K.Imai

Biomed. Choromatogr. 14(2) 118-124 2000年
D-Serine Concentration in Blood Serum of Liver Transplanted Patients.

S.Okubo, F.Mashige, Y.Hashimoto, K.Nakahara, H.Kanazawa, Y.Matsushima, T.Fukushima, Y.Huang, K.Imai

Chromatogr. 21 43-47 2000年
Study on the fluorescent 'on-off' properties of benzofurazan compounds bearing an aromatic substituent group and design of fluorescent 'on-off' derivatization reagents

S. Uchiyama, T. Santa, K. Imai

Analyst 125(10) 1839-1845 2000年
Ultramicroanalysis of Reducing Carbohydrates by Capillary Electrophoresis with Laser-Induced Fluorescence Detection as 7-Nitro-2, 1, 3-benzoxadiazole-Tagged ┣DBN(/)-┫DB-Methylglycamine Derivatives.

Anal. Biochem. 286(1) 99-111 2000年
Production of LLU-α Following an Oral Administration of γ-Tocotrienol or γ-Tocopherol to Rats.

Akihiro HATTORI, Takeshi FUKUSHIMA, Hiroyuki YOSHIMURA, Kouichi ABE, Kazuhiro IMAI

Biol. Pharm. Bull. 23(11) 1395-1397 2000年
An Automatic Analyzer for Catecholamines and Their 3-┣DBO(/)-┫DB-Methyl Metabolites Using a Micro Coulometric Flow Cell as a Postcolumn Reactor for Fluorogenic Reaction.

Anal. Chem. 72(17) 4009-4014 2000年
Semi-empirical PM3 calculations predict the fluorescence quantum yields(φ)of 4-monosubstituted benzofurazan compounds.

J. Chem. Soc., Perkin Trans. (6) 1199-1207 2000年
Development of water-soluble fluorogenic reagents having a 2,1,3-benzoxadiazole structure and their application to the determination of peptides

T Kajiro, T Fukushima, T Santa, K Imai

ANALYST 125(6) 1115-1121 2000年
Detection of 7-┣DBN(/)-┫DB, ┣DBN(/)-┫DB-dimethylaminosulfony1-4-(2, 1, 3-benzoxadiazolyl)carbamoyl amino acids generated by post-column desulfuration in the simultaneous determination of the sequence and D/L-configuration of peptides using a fluorogeni・・・

Anal. Chim. Acta 415(1/2) 57-66 2000年

Detection of 7-┣DBN(/)-┫DB, ┣DBN(/)-┫DB-dimethylaminosulfony1-4-(2, 1, 3-benzoxadiazolyl)carbamoyl amino acids generated by post-column desulfuration in the simultaneous determination of the sequence and D/L-configuration of peptides using a fluorogenic Edman reagent, 7-┣DBN(/)-┫DB, ┣DBN(/)-┫DB-dimethylaminosulfony1-4-(2, 1, 3-benzoxadiazolyl)isothiocyanate.
Development of an Amino Acid Sequence and D/L-Configuration Determination Method of Peptide with a New Fluorescence Edman Reagent, 7-Methylthio-4-(2, 1, 3-benzoxadiazolyl)Isothiocyanate

Anal. Chem. 72(4) 732-739 2000年
Occurrence and Determination of a Natriuretic Hormone, 2, 7, 8-Trimethyl-2-(-carboxyethyl)-6-hydroxy Chroman, in Rat Plasma, Urine, and Bile.

Anal. Biochem. 281(2) 209-215 2000年
New Approach for Measurement of Sympathetic Nervous Abnormality in Conscious, Spontaneously Hypertensive Rats.

Makoto Tsunoda, Kazuko Takezawa, Tomofumi Santa, Yasuhiro Ina, Ken Nagashima, Kenji Ohmori, Satoshi Kobayashi, Kazuhiro Imai

Jpn. J. Pharmacol. 83(1) 39-45 2000年
Fluorescent oxidation products derived from DBD-thiocarbamoyl amino acid in the modified Edman sequencing analysis.

Biomed. Choromatogr. 14(2) 133-136 2000年

書籍等出版物

17

バイオ・ケミルミネセンスハンドブック（共著）

丸善 2006年
FUNCTIONAL GROUP ANALYSIS.

Elsevier Ltd. 2005年
FUNCTIONAL GROUP ANALYSIS.

Elsevier Ltd. 2005年
スタンダード薬学シリーズ物理系薬学 Ⅱ.化学物質の分析第1章酸と塩基“酸塩基平衡を説明できる”（共著）

東京化学同人 2004年
機器分析化学（共著）

丸善 2002年

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講演・口頭発表等

60

FD-LC-MS/MS法を用いた乳癌細胞株のプロテオーム解析

第48回日本臨床学会年次学術集会 2008年
乳癌細胞株７種のFD-LC-MS/MSプロテオーム解析による転移性乳癌のバイオマーカー探索

第69回分析化学討論会 2008年
紫外線により惹起される皮膚障害に対するユビキノール-10水溶性プロドラッグの効果

日本薬学会第128年会 2008年
ユビキノール-10水溶性プロドラッグの発毛促進効果

日本薬学会第128年会 2008年
FD-LC-MS/MS法によるマウス肝臓タンパク質の加齢変動解析

日本薬学会第128年会 2008年

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所属学協会

11

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共同研究・競争的資金等の研究課題

2

生体成分の分析化学的研究

ライフサイエンス基礎科学研究 1977年 - 2006年
Analytical Chemical Studies on Biological Substances

Basic Science Research on Life Science 1977年 - 2006年

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