Curriculum Vitaes

Kazuhiro Imai

(今井一洋)

Profile Information

Affiliation: Professor,Director,Vice President, Research Institute of Pharmaceutical Sciences, Musashino University

Degree: Ph.D.
Master of pharmaceutical Sciences

J-GLOBAL ID: 200901058703864038
researchmap Member ID: 1000013291

Research Interests

2

Research Areas

1

Life sciences / Pharmaceuticals - analytical and physicochemistry /

Research History

11

2012 - Present

Visiting Professor, Musashino University, Research Institute of Pharmaceutical Sciences
2003 - Present

- 武蔵野大学教授
2003 - 2012

Professor, - Musashino University,
1993 - 2003

The University of Tokyo
1993 - 2003

The University of Tokyo, Professor

Education

4

Committee Memberships

11

1998 - 1999

会長, クロマトグラフィー科学会
1999

評議員、選考委員, 日本薬理学会
1998

会員, Academia Iberoamericana de Pharmacia
1995 - 1997

薬科学部会代議員, 国際薬学連合
1991 - 1994

評議員, 日本臨床化学会

Awards

7

Papers

2

Alteration of intracellular secretory acute phase response proteins expressed in human hepatocyte induced by exposure with interleukin-6 Liquid chromatographic separation of proteins derivatized with a fluorogenic reagent at cysteinyl residues on

K. Nakata, R. Saitoh, J. Amano, A. Koshiyama, T. Ichibangase, N. Murao, K. Ohta, Y. Aso, M. Ishigai, K. Imai

Cytokine, Sep, 2012 Peer-reviewed
A toxicoproteomic study on cardioproteactive effects of pre-administration of docetaxel in a mouse model of adriamycin-induced cardiotoxicity

Biochem. Pharm., 2010

Misc.

246

Determination of rat blood S-D-lactoylglutathione by a column-switching high-performance liquid chromatography with precolumn fluorescence derivatization with 4-fluoro-7-nitro-2,1,3-benzoxadiazole

E Uchino, T Fukushima, M Tsunoda, T Santa, K Imai

ANALYTICAL BIOCHEMISTRY, 330(2) 186-192, Jul, 2004
Distinguishing the 5,5-dimethyl-1-pyrroline N-oxide (DMPO)-OH radical quenching effect from the hydroxyl radical scavenging effect in the ESR spin-trapping method

LX Li, Y Abe, K Kanagawa, N Usui, K Imai, T Mashino, M Mochizuki, N Miyata

ANALYTICA CHIMICA ACTA, 512(1) 121-124, Jun, 2004
Precision, limit of detection and range of quantitation in competitive ELISA

Y Hayashi, R Matsuda, T Maitani, K Imai, W Nishimura, K Ito, M Maeda

ANALYTICAL CHEMISTRY, 76(5) 1295-1301, Mar, 2004
Possible role of D-serine in the pathophysiology of Alzheimer's disease

K Hashimoto, T Fukushima, E Shimizu, SI Okada, N Komatsu, N Okamura, K Koike, H Koizumi, C Kumakiri, K Imai, M Iyo

PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY, 28(2) 385-388, Mar, 2004
Fluorogenic derivatization reagents suitable for isolation and identification of cysteine-containing proteins utilizing high-performance liquid chromatography-tandem mass spectrometry

M Masuda, C Toriumi, T Santa, K Imai

ANALYTICAL CHEMISTRY, 76(3) 728-735, Feb, 2004
Determination of serum D-lactic and L-lactic acids in normal subjects and diabetic patients by column-switching HPLC with pre-column fluorescence derivatization

H Hasegawa, T Fukushima, JA Lee, K Tsukamoto, K Moriya, Y Ono, K Imai

ANALYTICAL AND BIOANALYTICAL CHEMISTRY, 377(5) 886-891, Nov, 2003
Study on interactions of endocrine disruptors with estrogen receptor-β using fluorescence polarization

Sachiko Suzuki, Ken-Ichi Ohno, Tomofumi Santa, Kazuhiro Imai

Analytical Sciences, 19(8) 1103-1108, Aug 1, 2003
High-performance liquid chromatography-fluorescent assay of catechol-O-methyltransferase activity in rat brain

M Masuda, M Tsunoda, K Imai

ANALYTICAL AND BIOANALYTICAL CHEMISTRY, 376(7) 1069-1073, Aug, 2003
An identification method for altered proteins in tissues utilizing fluorescence derivatization, liquid chromatography, tandem mass spectrometry, and a database-searching algorithm

C Toriumi, K Imai

ANALYTICAL CHEMISTRY, 75(15) 3725-3730, Aug, 2003
First fluorescent photoinduced electron transfer (PET) reagent for hydroperoxides

M Onoda, S Uchiyama, A Endo, H Tokuyama, T Santa, K Imal

ORGANIC LETTERS, 5(9) 1459-1461, May, 2003
生命機能の分子認識と捕捉の高精密化に関する分析化学的研究

今井一洋

薬学雑誌, 123(11) 901-917, 2003
Study on Interactions of Endocrine Disruptors with Estrogen Receptor-β Using Fluorescence Polarization.

Anal.Sci., 19, 1103-1108, 2003
Decreased Serum Levels of D-Serine in Patients With Schizophrenia.

Arch.Gen.Psychiatry, 60, 572-576, 2003
Reduced Membrane-Bound Catechol-O-Methyltransferase in the Liver of Spontaneously Hypertensive Rats.

Hypertens.Res., 26, 923-927, 2003
Recent Progress in Derivatization Methods for LC and CE Analysis.

J.Pharm.Biomed.Anal., 30, 1655-1687, 2003
Fluorescent derivatization reagents for thiols bearing a new type of fluorophores:7-fluoro-2, 1, 3-benzoselenadia zole-4-sulfonate and 7-fluoro-2, 1, 3-benzothiadiazole-4-sulfonate

Proc. Japan Acad., 79, Ser. B/ , 137-140, 2003
Altered expression of insulins I and II and their mRNAs in the islets of Langerhans in dexamethasone-induced diabetic rats

C Toriumi, K Imai

BIOMEDICAL CHROMATOGRAPHY, 17(1) 26-32, Jan, 2003
Enumeration of Bacterial Cell Numbers by Amplified Firefly Bioluminescence without Cultivation.

SAKAKIBARA T, MURAKAMI S, IMAI K

Anal. Biochem.,, 312(1) 48-56, 2003
Decreased Serum Levels of D-Serine in Patients With Schizophrenia.

Arch.Gen.Psychiatry, 60, 572-576, 2003
Reduced Membrane-Bound Catechol-O-Methyltransferase in the Liver of Spontaneously Hypertensive Rats.

Hypertens.Res., 26, 923-927, 2003
Recent Progress in Derivatization Methods for LC and CE Analysis.

J.Pharm.Biomed.Anal., 30, 1655-1687, 2003
Study on interactions of endocrine disruptors with estrogen receptor using fluorescence polarization

K Ohno, S Suzuki, T Fukushima, M Maeda, T Santa, K Imai

ANALYST, 128(8) 1091-1096, 2003
Fluorescent derivatization reagents for thiols bearing a new type of fluorophores:7-fluoro-2, 1, 3-benzoselenadia zole-4-sulfonate and 7-fluoro-2, 1, 3-benzothiadiazole-4-sulfonate

Proc. Japan Acad., 79, Ser. B/ , 137-140, 2003
Enumeration of Bacterial Cell Numbers by Amplified Firefly Bioluminescence without Cultivation.

Anal. Biochem.,, 312(1) 48-56, 2003
Altered expression of insulins I and II and their mRNAs in the islets of Langerhans in dexamethasone-induced diabetic rats

C Toriumi, K Imai

BIOMEDICAL CHROMATOGRAPHY, 17(1) 26-32, Jan, 2003
Novel d-gamma-tocopherol derivative as a prodrug for d-gamma-tocopherol and a two-step prodrug for S-gamma-CEHC

J Takata, R Hidaka, A Yamasaki, A Hattori, T Fukushima, M Tanabe, K Matsunaga, Y Karube, K Imai

JOURNAL OF LIPID RESEARCH, 43(12) 2196-2204, Dec, 2002
Design and synthesis of a hydrophilic fluorescent derivatization reagent for carboxylic acids, 4-N-(4-N-aminoethyl)piperazino-7-nitro-2,1,3-benzoxadiazole (NBD-PZ-NH2), and its application to capillary electrophoresis with laser-induced fluorescence detection

T Santa, D Matsumura, CZ Huang, C Kitada, K Imai

BIOMEDICAL CHROMATOGRAPHY, 16(8) 523-528, Dec, 2002
Novel d-gamma-tocopherol derivative as a prodrug for d-gamma-tocopherol and a two-step prodrug for S-gamma-CEHC

J Takata, R Hidaka, A Yamasaki, A Hattori, T Fukushima, M Tanabe, K Matsunaga, Y Karube, K Imai

JOURNAL OF LIPID RESEARCH, 43(12) 2196-2204, Dec, 2002
Rat liver and kidney catechol-O-methyltransferase activity measured by high-performance liquid chromatography with fluorescence detection

M Tsunoda, K Takezawa, M Masuda, K Imai

BIOMEDICAL CHROMATOGRAPHY, 16(8) 536-541, Dec, 2002
Design and synthesis of a hydrophilic fluorescent derivatization reagent for carboxylic acids, 4-N-(4-N-aminoethyl)piperazino-7-nitro-2,1,3-benzoxadiazole (NBD-PZ-NH2), and its application to capillary electrophoresis with laser-induced fluorescence detection

T Santa, D Matsumura, CZ Huang, C Kitada, K Imai

BIOMEDICAL CHROMATOGRAPHY, 16(8) 523-528, Dec, 2002
Assay of catechol-O-methyltransferase activity in human erythrocytes using norepinephrine as a natural substrate

M Masuda, M Tsunoda, Y Yusa, S Yamada, K Imai

ANNALS OF CLINICAL BIOCHEMISTRY, 39 589-594, Nov, 2002
A method to evaluate the renin-angiotensin system in rat renal cortex using a microdialysis technique combined with HPLC fluorescence detection

T Kajiro, Y Nakajima, T Fukushima, K Imai

ANALYTICAL CHEMISTRY, 74(17) 4519-4525, Sep, 2002
Estrogen receptor binding assay method for endocrine disruptors using fluorescence polarization

K Ohno, T Fukushima, T Santa, N Waizumi, H Tokuyama, M Maeda, K Imai

ANALYTICAL CHEMISTRY, 74(17) 4391-4396, Sep, 2002
A photoinduced electron-transfer reagent for peroxyacetic acid, 4-ethylthioacetylamino-7-phenylsulfonyl-2,1,3-benzoxadiazole, based on the method for predicting the fluorescence quantum yields

M Onoda, S Uchiyama, T Santa, K Imai

ANALYTICAL CHEMISTRY, 74(16) 4089-4096, Aug, 2002
Development of 7-(N,N-dimethylaminosulfonyl)-5-N-(4-N- aminoethyl)piperazino-2,1,3-benzoxadiazole as a water-soluble fluorogenic reagent for the sensitive liquid chromatographic determination of saturated carboxylic acids

CZ Huang, T Santa, K Imai

ANALYST, 127(6) 741-747, Jun, 2002
A rapid assay method for catechol-O-methyltransferase activity by flow injection analysis

N Aoyama, M Tsunoda, K Nakagomi, K Imai

BIOMEDICAL CHROMATOGRAPHY, 16(4) 255-260, Jun, 2002
Determination of insulin in a single islet of Langerhans by high-performance liquid chromatography with fluorescence detection

C Toriumi, K Imai

ANALYTICAL CHEMISTRY, 74(10) 2321-2327, May, 2002
An automated fluorescence protein sequencer using 7-methylthio-4-(2,1,3-benzoxadiazolyl) isothiocyanate (MTBD-NCS) as an Edman reagent

N Okiyama, T Santa, A Toriba, K Nakagomi, K Imai, H Hiranuma, H Tanaka

BIOMEDICAL CHROMATOGRAPHY, 16(3) 183-186, May, 2002
Development of Hydrophilic Fluorogenic Derivatization Reagents for Thiols: 4-(N-acetylaminosulfony1)-7-fluoro-2, 1, 3-benzoxadiazole and 4-(N-trichloroacetylaminosulfony1)-7-fluoro-2, 1, 3-benzoxadiazole.

OKABE K, WADA R, OHNO K, UCHIYAMA S, SANTA T, IMAI K

J. Chromatogr., 982(1) 111-118, 2002
'Synthesis and Fluorescence Properties of 4, 5-, 4, 6- and 5, 6- Disubstituted Benzofurzan(2, 1, 3-Benzoxadiazole)Compounds.'

Heterocycles., 58(1) 65-173, 2002
Estrogen Receptor Binding Assay Method for Endocrine Disruptors Using Fluorescence Polarization.

Anal. Chem., 74, 4391-4396, 2002
Simultaneous Determination of 3, 4-dihydroxyphenylacetic Acid and Homovanillic Acid using Higu Performance Liquid Chromatography-fluorescence Detection and Application to Rat Kidney Microdialysate.

Anal. Biochem., 307, 153-158, 2002
Development of 7-(N,N-Dimethylaminosulfonyl)-N-(4-N-aminoethy)piperazino-2, 1, 3-benzoxadiazole as a Water-soluble Fluorogenic Reagent for the Sensitive Liquid Chromatographic Determination of Saturated Carboxylic Acids.

Analyst, 127, 741-747, 2002
The Effects of Spacer Length on the Fluorescence Quantum Yields of the Benzofurazan Compounds Bearing a Donor-acceptor System.

Luminescence, 17, 11-14, 2002
An Automated Analyzer for Methylated Arginines in Rat Plasma by High-Performance Liquid Chromatography with Post-Column Fluorescence Reaction.

Analyst, 127, 54-59, 2002
Development of Hydrophilic Fluorogenic Derivatization Reagents for Thiols: 4-(N-acetylaminosulfony1)-7-fluoro-2, 1, 3-benzoxadiazole and 4-(N-trichloroacetylaminosulfony1)-7-fluoro-2, 1, 3-benzoxadiazole.

J. Chromatogr., 982(1) 111-118, 2002
'Synthesis and Fluorescence Properties of 4, 5-, 4, 6- and 5, 6- Disubstituted Benzofurzan(2, 1, 3-Benzoxadiazole)Compounds.'

Heterocycles., 58(1) 65-173, 2002
Photophysical study of 5-substituted benzofurazan compounds as fluorogenic probes

S Uchiyama, K Takehira, S Kohtani, T Santa, R Nakagaki, S Tobita, K Imai

PHYSICAL CHEMISTRY CHEMICAL PHYSICS, 4(18) 4514-4522, 2002
Simultaneous Determination of 3, 4-dihydroxyphenylacetic Acid and Homovanillic Acid using Higu Performance Liquid Chromatography-fluorescence Detection and Application to Rat Kidney Microdialysate.

Anal. Biochem., 307, 153-158, 2002
Determination of fluoxetine enantiomers in rat plasma by pre-column fluorescence derivatization and column-switching high-performance liquid chromatography

XJ Guo, T Fukushima, FM Li, K Imai

ANALYST, 127(4) 480-484, 2002

Books and Other Publications

17

バイオ・ケミルミネセンスハンドブック（共著）

丸善, 2006
FUNCTIONAL GROUP ANALYSIS.

Elsevier Ltd., 2005
FUNCTIONAL GROUP ANALYSIS.

Elsevier Ltd., 2005
スタンダード薬学シリーズ物理系薬学 Ⅱ.化学物質の分析第1章酸と塩基“酸塩基平衡を説明できる”（共著）

東京化学同人, 2004
機器分析化学（共著）

丸善, 2002

Presentations

60

FD-LC-MS/MS法を用いた乳癌細胞株のプロテオーム解析

第48回日本臨床学会年次学術集会, 2008
乳癌細胞株７種のFD-LC-MS/MSプロテオーム解析による転移性乳癌のバイオマーカー探索

第69回分析化学討論会, 2008
紫外線により惹起される皮膚障害に対するユビキノール-10水溶性プロドラッグの効果

日本薬学会第128年会, 2008
ユビキノール-10水溶性プロドラッグの発毛促進効果

日本薬学会第128年会, 2008
FD-LC-MS/MS法によるマウス肝臓タンパク質の加齢変動解析

日本薬学会第128年会, 2008

Professional Memberships

11

Research Projects

2

生体成分の分析化学的研究

ライフサイエンス基礎科学研究, 1977 - 2006
Analytical Chemical Studies on Biological Substances

Basic Science Research on Life Science, 1977 - 2006

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