Curriculum Vitaes

Kohfuku Kohda

(幸田光復)

Profile Information

Affiliation: Professor, Research Institute of Pharmaceutical Sciences, Musashino University

Degree: (BLANK)
(BLANK)

J-GLOBAL ID: 200901008223441849
researchmap Member ID: 1000055199

Research Areas

1

Nanotechnology/Materials / Biochemistry /

Education

4

- 1975

The University of Tokyo
- 1975

Graduate School, Division of Pharmaceutical Sciences, The University of Tokyo
- 1969

Yokohama National University
- 1969

Faculty of Engineering, Yokohama National University

Awards

1

1984

佐藤記念国内賞

Misc.

238

Electrophilic amination of adenine. Formation of N-aminoadenines and their characteristics.

Nucleosides & Nucleotides, 15 219-233, 1996
Cytotoxicity of antitumor agents toward cultured murine leukemia L1210 cells under a serum-deprived apoptotic condition

T Kasamatsu, K Kohda, Y Kawazoe

ANTICANCER RESEARCH, 15(6B) 2597-2600, Nov, 1995
STRUCTURE-CYTOTOXICITY RELATIONSHIP OF TILIVALLINE DERIVATIVES

T SHIOIRI, T AOYAMA, N YAMAGAMI, N SHIMIZU, N MORI, K KOHDA

ANTI-CANCER DRUG DESIGN, 10(2) 167-176, Mar, 1995
Differential inactivation of O⁶-methylguanine-DNA methyltransferase activity by O⁶-arylmethylguanines. K. Mineura, M. Fukuchi, M. Kowada, I. Terashima, and K. Kohda

Int. J. Cancer, 63, 148-151, 1995
Mouse methyltransferase for repair of O⁶-methylguanine and O⁴-methylthymine in DNA. M. Kawate, K. Ihara, K. Kohda, K. Sakumi, and M. Sekiguchi

Carcinogenesis, 16, 1595-1602, 1995
Wide difference between the cytotoxicity of the 11-α- and 11-β-cyano analogues of tilivalline and their epimeric conversion. K. Kohda, N. Yamagami, T. Kasamatsu, T. Aoyama, and T. Shioiri

Biochem. Pharmacol., 49, 1063-1068, 1995
Potentiation of the cytotoxicity of chloroethylnitrosourea by O⁶-arylmethylguanines. K. Kohda, I. Terashima, K. Koyama, K. Watanabe, and K. Mineura

Biol. Pharm. Bull., 18, 424-430, 1995
Differential inactivation of O⁶-methylguanine-DNA methyltransferase activity by O⁶-arylmethylguanines. K. Mineura, M. Fukuchi, M. Kowada, I. Terashima, and K. Kohda

Int. J. Cancer, 63, 148-151, 1995
Mouse methyltransferase for repair of O⁶-methylguanine and O⁴-methylthymine in DNA. M. Kawate, K. Ihara, K. Kohda, K. Sakumi, and M. Sekiguchi

Carcinogenesis, 16, 1595-1602, 1995
Wide difference between the cytotoxicity of the 11-α- and 11-β-cyano analogues of tilivalline and their epimeric conversion. K. Kohda, N. Yamagami, T. Kasamatsu, T. Aoyama, and T. Shioiri

Biochem. Pharmacol., 49, 1063-1068, 1995
Potentiation of the cytotoxicity of chloroethylnitrosourea by O⁶-arylmethylguanines. K. Kohda, I. Terashima, K. Koyama, K. Watanabe, and K. Mineura

Biol. Pharm. Bull., 18, 424-430, 1995
3-AMINOTHYMIDINE INHIBITS GROWTH OF CULTURED HUMAN T-CELL ACUTE LYMPHOBLASTOID LEUKEMIA-CELLS

N ASHIDA, S ASANO, K KOHDA

ANTICANCER RESEARCH, 14(5A) 2061-2062, Sep, 1994
ENHANCING EFFECT OF O-6-ALKYLGUANINE DERIVATIVES ON CHLOROETHYLNITROSOUREA CYTOTOXICITY TOWARD TUMOR-CELLS

K MINEURA, IZUMI, I, K WATANABE, M KOWADA, K KOHDA, K KOYAMA, TERASHIMA, I, M IKENAGA

INTERNATIONAL JOURNAL OF CANCER, 58(5) 706-712, Sep, 1994
ENHANCED CYTOTOXICITY CAUSED BY INCREASED DNA STRAND BREAKAGE RESULTING FROM SYNERGISTIC POTENTIATION OF BLEOMYCIN WITH BACILLUS-THURINGIENSIS SUBSP ISRAELENSIS DELTA-ENDOTOXIN

Y YOKOYAMA, K KOHDA

ANTICANCER RESEARCH, 14(3A) 837-840, May, 1994
ENHANCED CYTOTOXICITY CAUSED BY INCREASED DNA STRAND BREAKAGE RESULTING FROM SYNERGISTIC POTENTIATION OF BLEOMYCIN WITH BACILLUS-THURINGIENSIS SUBSP ISRAELENSIS DELTA-ENDOTOXIN

Y YOKOYAMA, K KOHDA

ANTICANCER RESEARCH, 14(3A) 837-840, May, 1994
DEMETHYLATION OF O-6-METHYLGUANIUE IN DNA BY O-6-METHYLGUANINE-DNA METHYLTRANSFERASE - SYNTHESIS AND CHARACTERIZATION OF O-6,9-DIMETHYLGUANINE COORDINATED WITH CISPLATIN AT THE N7-POSITION

TERASHIMA, I, Y YAMAGATA, N YAMAGAMI, K KOHDA

CHEMICAL & PHARMACEUTICAL BULLETIN, 42(4) 903-906, Apr, 1994
DEMETHYLATION OF O-6-METHYLGUANIUE IN DNA BY O-6-METHYLGUANINE-DNA METHYLTRANSFERASE - SYNTHESIS AND CHARACTERIZATION OF O-6,9-DIMETHYLGUANINE COORDINATED WITH CISPLATIN AT THE N7-POSITION

TERASHIMA, I, Y YAMAGATA, N YAMAGAMI, K KOHDA

CHEMICAL & PHARMACEUTICAL BULLETIN, 42(4) 903-906, Apr, 1994
Reactions of 9-substituted 1-aminoadenines with nucleophiles and syntheses of 3-substituted 3H-imidazo[4, 5-e][1, 2, 4]triazolo[1, 5-c][1, 2, 3]triazines. S. Asano, K. Itano, Y. Yamagata, and K. Kohda

Nucleosides & Nucleotides, 13, 1453-1465, 1994
Inhibitory effect of fatty acids on 8-hydroxydeoxyguanosine formation in calf thymus DNA treated with bleomycin-Fe(Ⅱ). T. Kasamatsu, T. Nakagawa, and K. Kohda

Biol. Pharm. Bull., 17, 391-394, 1994
POTENTIAL OF O6-METHYLGUANINE OR O6-BENZYLGUANINE IN THE ENHANCEMENT OF CHLOROETHYLNITROSOUREA CYTOTOXICITY ON BRAIN-TUMORS

K MINEURA, IZUMI, I, K WATANABE, M KOWADA, K KOHDA, M KENAGA

ACTA NEUROCHIRURGICA, 128(1-4) 13-20, 1994
Reactions of 9-substituted 1-aminoadenines with nucleophiles and syntheses of 3-substituted 3H-imidazo[4, 5-e][1, 2, 4]triazolo[1, 5-c][1, 2, 3]triazines. S. Asano, K. Itano, Y. Yamagata, and K. Kohda

Nucleosides & Nucleotides, 13, 1453-1465, 1994
Inhibitory effect of fatty acids on 8-hydroxydeoxyguanosine formation in calf thymus DNA treated with bleomycin-Fe(Ⅱ). T. Kasamatsu, T. Nakagawa, and K. Kohda

Biol. Pharm. Bull., 17, 391-394, 1994
Electrophilic amination of imidazole moieties of 9-ethylguanine and 1-methylbenzimidazole derivatives and reactivities of N-aminated products. T. Kaiya, M. Ohta, and K. Kohda

Tetrahedron, 49, 8795-8804, 1993
Chemical characteristics of N-aminated nucleic acid bases. Nitrosation of aromatic N-amino group and accompanying reductive deamination. K. Hasebe, and K. Kohda

Nucleic Acids Symp. Ser., (29) 27-28, 1993
Identification of N⁴-(guanosin-7-yl)-4-aminoquinoline 1-oxide and its possible role in guanine C8 adducation. M. Tada, and K. Kohda

Nucleic Acids Symp. Ser., 29(25-26), 1993
Chemical characteristics of complexes of O⁶, 9-dimethylguanine with cis-platin and debenzylation rates of O⁶-benzylguanines. I. Terashima, K. Koyama, and K. Kohda

Nucleic Acids Symp. Ser., (29) 23-24, 1993
Syntheses and properties of N-aminopyrimidines. K. Kohda, I. Kobayashi, K. Itano, S. Asano, and Y. Kawazoe

Tetrahedron, 49, 3947-3958, 1993
Electrophilic amination of imidazole moieties of 9-ethylguanine and 1-methylbenzimidazole derivatives and reactivities of N-aminated products. T. Kaiya, M. Ohta, and K. Kohda

Tetrahedron, 49, 8795-8804, 1993
Chemical characteristics of N-aminated nucleic acid bases. Nitrosation of aromatic N-amino group and accompanying reductive deamination. K. Hasebe, and K. Kohda

Nucleic Acids Symp. Ser., (29) 27-28, 1993
Identification of N⁴-(guanosin-7-yl)-4-aminoquinoline 1-oxide and its possible role in guanine C8 adducation. M. Tada, and K. Kohda

Nucleic Acids Symp. Ser., 29(25-26), 1993
Chemical characteristics of complexes of O⁶, 9-dimethylguanine with cis-platin and debenzylation rates of O⁶-benzylguanines. I. Terashima, K. Koyama, and K. Kohda

Nucleic Acids Symp. Ser., (29) 23-24, 1993
Syntheses and properties of N-aminopyrimidines. K. Kohda, I. Kobayashi, K. Itano, S. Asano, and Y. Kawazoe

Tetrahedron, 49, 3947-3958, 1993
Hyperthermic potentiation of bleomycin cytotoxicity in the presence of ┣DBBacillus(/)-┫DB ┣DBthuringiensis(/)-┫DB subsp. ┣DBisraelensis(/)-┫DB d-endotoxin

┣DBAnticancer Res.(/)-┫DB, 12 1079-1082, 1992
Structures of N-aminoguanine hydrochloride salts. Y. Yamagata, K. Tomita, K. Kohda, and Y. Kawazoe

Acta Crystallogr., Sect.C, 48, 318-320, 1992
Hyperthermic potentiation of bleomycin cytotoxicity in the presence of ┣DBBacillus(/)-┫DB ┣DBthuringiensis(/)-┫DB subsp. ┣DBisraelensis(/)-┫DB d-endotoxin

┣DBAnticancer Res.(/)-┫DB, 12 1079-1082, 1992
Structures of N-aminoguanine hydrochloride salts. Y. Yamagata, K. Tomita, K. Kohda, and Y. Kawazoe

Acta Crystallogr., Sect.C, 48, 318-320, 1992
SPIN-SPIN COUPLING BETWEEN FLUORINE AND AROMATIC PROTONS OF 3-FLUOROQUINOLINE - DEPENDENCE ON THE ELECTRONIC-STRUCTURE OF THE RING NITROGEN

K SAEKI, K KOHDA, Y KAWAZOE, Y SAKAMOTO

HETEROCYCLES, 33(1) 35-38, Jan, 1992
Potentiation of antitumor activity of bleomycin towards solid tumors in mice by ┣DBBacillus(/)-┫DB ┣DBthuringiensis(/)-┫DB subsp. ┣DBIsraelensis(/)-┫DB toxin

┣DBAnticancer Res.(/)-┫DB, 11 1625-1628, 1991
Syntheses and properties of N-aminated purines and pyrimidines

┣DBNucleic Acids, Symposium Series(/)-┫DB, 25 3-4, 1991
Potentiation of bleomycin cytotoxicity in cultured mammalian cells by polyacrylic acid. III. Induction of DNA strand breakage and suppression of cellular heat production

┣DBAnticancer Res.(/)-┫DB, 11 957-960, 1991
Potentiation of bleomycin cytotoxicity by higy molecular weight polyacrylic acid. II. Involvement of rapid conformational change of polyacrylate

┣DBAnticancer Res.(/)-┫DB, 11 953-956, 1991
Separation and identification of N⁴-(guanosin-7-yl)-4-aminoquinoline l-oxide, a novel nucleic acid adduct of arcinogenic 4-nitroquinoline 1-oxide. K. Kohda, Y. Kawazoe, Y. Minoura, and M. Tada

Carcinoenesis, 12, 1523-1525, 1991
Detection of 8-hydroxy-2'-deoxyguanosine in DNA by the 32p-postlabeling method

田坂文代, 幸田光復

┣DBChem. Pharm. Bull.(/)-┫DB, 39(7) 1880-1882, 1991
Some cytotoxicological aspects of ethyl and fluoroethyl alkanesulfonates in ┣DBEscherichia(/)-┫DB ┣DBcoli(/)-┫DB : Role of fluorine substitution

┣DBChem. Pharm. Bull.(/)-┫DB, 39 1510-1512, 1991
Lignified materials as a potential medicinal resource. IV. Dehydrogenation polymers of some phenylpropenids and their capacity to stimulate polymorphonuclear cell iodination

坂上宏, 大原利成, 幸田光復, 川添豊

┣DBChem. Pharm. Bull.(/)-┫DB, 39(4) 950-955, 1991
Differential inhibition of retroviral reverse transcriptase by poly(2-fluoroadenylic acid), a template analogue

┣DBAIDS(/)-┫DB, 5 341-341, 1991
Dealkylation rates of O⁶-alkyldeoxyguanosine, O⁴-alkylthymidine and related compounds under an alkyl-transfer system. K. Kohda, M. Yasuda, N. Sawada, K. Itano, and Y. Kawazoe

Chemico-Biol. Interactions, 78, 23-32, 1991
Formation of ┣DBO⁶(/)-┫DB, 7-dimethylguanine residues in calf thymus DNA treated with carcinogenic ┣D5N-┫D5-methyl-┣D5N-┫D5-nitrosourea ┣DBin vitro(/)-┫DB

┣DBChem. Pharm. Bull.(/)-┫DB, 39 801-802, 1991
Potentiation of antitumor activity of bleomycin towards solid tumors in mice by ┣DBBacillus(/)-┫DB ┣DBthuringiensis(/)-┫DB subsp. ┣DBIsraelensis(/)-┫DB toxin

┣DBAnticancer Res.(/)-┫DB, 11 1625-1628, 1991
Syntheses and properties of N-aminated purines and pyrimidines

┣DBNucleic Acids, Symposium Series(/)-┫DB, 25 3-4, 1991

Books and Other Publications

14

Miscoding potential of the ┣DBN(/)-┫DB²-ethyl-2'-deoxyguanosine DNA adduct by the exonuclease-free Klenow fragment of ┣DBEscherichia coli(/)-┫DB DNA polymerase (]G0001[)(共著)

┣DBBiochemistry(/)-┫DB, 2001
Miscoding potential of the ┣DBN(/)-┫DB²-ethyl-2'-deoxyguanosine DNA adduct by the exonuclease-free Klenow fragment of ┣DBEscherichia coli(/)-┫DB DNA polymerase (]G0001[)(共著)

┣DBBiochemistry(/)-┫DB, 2001
Syntheses and properties of 1-methyl-3-phenylaminobenzimidazolium salts, models of DNA adducts of N7-arylaminodeoxyguanosinium salt.(共著)

┣DBChem. Res. Toxicol.(/)-┫DB, 2000
┣DBO(/)-┫DB⁶-(Fluorobenzyl)guanine and chloroethylnitrosourea in xenografted rat brain tumor in vivo.(共著)

┣DBActa Oncol.(/)-┫DB, 2000
Reactions of a series of ┣DBN(/)-┫DB-aminobenzimidazoles and ┣DBN(/)-┫DB-aminobenzimidazolium salts with 2, 4-pentanedione.(共著)

┣DBBioorg. Med. Chem.(/)-┫DB, 2000

Professional Memberships

3

Research Projects

2

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