Curriculum Vitaes

ENOMOTO TAKEMI

(榎本武美)

Profile Information

Affiliation: Professor, Musashino University

Degree: 学士(東京大学)
修士(東京大学)
博士(東京大学)

J-GLOBAL ID: 200901056088076439
researchmap Member ID: 1000183964

Research Interests

6

Research Areas

1

Life sciences / Molecular biology /

Research History

18

Education

7

- 1981

アルバートアインシュタイン医科大学
- 1975

The University of Tokyo
- 1975

Graduate School, Division of Pharmaceutical Sciences, The University of Tokyo
- 1972

The University of Tokyo
- 1972

Graduate School, Division of Pharmaceutical Sciences, The University of Tokyo

Misc.

267

Immunohistochemical expression and pathogenesis of BLM in the human brain and visceral organs

Y Hachiya, K Motonaga, M Itoh, T Masuko, T Enomoto, H Sonobe, S Takashima

NEUROPATHOLOGY, 21(2) 123-128, Jun, 2001
The N-terminal internal region of BLM is required for the formation of dots/rod-like structures which are associated with SUMO-1.

Suzuki, H, Seki, M, Kobayashi, T, Kawabe, Y, Kaneko, H, Kondo, N, Harata, M, Mizuno, S, Masuko, T, nomoto, T

Biochem. Biophys. Res. Commun., 286(2) 322-327, 2001

200100
Molecular cloning of a cDNA encoding mouse DNA helicase B, which has homology to Escherichia coli RecD protein, and identification of a mutation in the DNA helicase B from tsFT848 temperature-sensitive DNA replication mutant cells.

Tada, S, Kobayashi, T, Omori, A, Kusa, Y, Okumura, N, Kodaira, H, Ishimi, Y, Seki, M, nomoto, T

Nuc. Acids Res., 29(18) 3835-3840, 2001

200100
Involvement of SGS1 in DNA damage-induced heteroallelic recombination that requires RAD52.

Onoda, F, Seki, M, Miyajima, A, nomoto, T

Mol. Gen. Gnet., 264(5) 702-708, 2001

200100
A novel protein interacts with the Werner's syndrome gene product physically and functionally.

Kawabe, Y, Branzei, D, Suzuki, H, Masuko, T, Onoda, F, Heo, S.-J, Ikeda, H, Shimamoto, A, Fruichi, Y, Seki, M, nomoto, T

J. Biol. Chem., 276(23) 20364-20369, 2001

200100
The N-terminal internal region of BLM is required for the formation of dots/rod-like structures which are associated with SUMO-1.

Biochem. Biophys. Res. Commun., 286(2) 322-327, 2001

200100
Phage display cloning and characterization of monoclonal antibody genes and recombinant Fab fragment against the CD98 oncoprotein

Kunihiko Itoh, Kazuyuki Inoue, Kazumi Hirooka, Kumiko Maruyama, Mayumi Ohkawa, Kazuhiro Matsui, Hitoshi Tada, Takemi Enomoto, Yoshiyuki Hashimoto, Toshio Suzuki, Takashi Masuko

Japanese Journal of Cancer Research, 92(12) 1313-1321, 2001
Monoclonal antibody (5F3) defining renal cell carcinoma-associated antigen disialosyl globopentaosylceramide (V 3NeuAclV 6NeuAcGb5), and distribution pattern of the antigen in tumor and normal tissues

Akihiro Ito, Seiichi Saito, Takashi Masuko, Masayoshi Oh-Eda, Tetsu Matsuura, Makoto Satoh, Fatemeh Moosavi Nejad, Takemi Enomoto, Seiichi Orikasa, Sen-Itiroh Hakomori

Glycoconjugate Journal, 18(6) 475-485, 2001
Molecular cloning of a cDNA encoding mouse DNA helicase B, which has homology to Escherichia coli RecD protein, and identification of a mutation in the DNA helicase B from tsFT848 temperature-sensitive DNA replication mutant cells.

Nuc. Acids Res., 29(18) 3835-3840, 2001

200100
Involvement of SGS1 in DNA damage-induced heteroallelic recombination that requires RAD52.

Mol. Gen. Gnet., 264(5) 702-708, 2001

200100
A novel protein interacts with the Werner's syndrome gene product physically and functionally.

J. Biol. Chem., 276(23) 20364-20369, 2001

200100
Enhanced tumorigenicity caused by truncation of the extracellular domain of GP125/CD98 heavy chain

K Hara, H Kudoh, T Enomoto, Y Hashimoto, T Masuko

ONCOGENE, 19(54) 6209-6215, Dec, 2000
Different domains of Sgs1 are required for mitotic and meiotic functions

A Miyajima, M Seki, F Onoda, A Ui, Y Satoh, Y Ohno, T Enomoto

GENES & GENETIC SYSTEMS, 75(6) 319-326, Dec, 2000
Differential regulation of human RecQ family helicases in cell transformation and cell cycle

T Kawabe, N Tsuyama, S Kitao, K Nishikawa, A Shimamoto, M Shiratori, T Matsumoto, K Anno, T Sato, Y Mitsui, M Seki, T Enomoto, M Goto, NA Ellis, T Ide, Y Furuichi, M Sugimoto

ONCOGENE, 19(41) 4764-4772, Sep, 2000
Elevation of sister chromatid exchange in Saccharomyces cerevisiae sgs1 disruptants and the relevance of the disruptants as a system to evaluate mutations in Bloom's syndrome gene

Fumitoshi Onoda, Masayuki Seki, Atsuko Miyajima, Takemi Enomoto

Mutation Research - DNA Repair, 459(3) 203-209, Apr 28, 2000
Transformation of BALB3T3 cells caused by over-expression of rat CD98 heavy chain (HC) requires its association with light chain: mis-sense mutation in a cysteine residue of CD98HC eliminates its transforming activity.

Shishido, T, Uno, S, Kamohara, M, Tsuneoka-Suzuki, T, Hashimoto, Y, nomoto, T, Masuko, T

Int. J. Cancer, 87(3) 311-316, 2000

200000
Sgs1 helicase activity is required for mitotic but apparently not for meiotic functions.

Miyajima, A, Seki, M, Onoda, F, Shiratori, M, Odagiri, N, Ohta, K, Kikuchi, Y, Ohno, Y, nomoto, T

Mol. Cell. Biol., 20(17) 6399-6409, 2000

200000
Covalent modification of the Werner's syndrome gene product with the ubiquitin-related protein, SUMO-1.

Kawabe, Y, Seki, M, Seki, T, Wang, W-S, Imamura, O, Furuichi, Y, Saitoh, H, nomoto, T

J. Biol. Chem., 275(28) 20963-20966, 2000

200000
Possible association of BLM in decreasing DNA double strand breaks during DNA replication.

Wang, W, Seki,M, Narita, Y, Sonoda, E, Takeda, S, Yamada, K, Masuko, T, Katada, T, nomoto, T

EMBO J., 19(13) 3428-3435, 2000

200000
Transformation of BALB3T3 cells caused by over-expression of rat CD98 heavy chain (HC) requires its association with light chain: mis-sense mutation in a cysteine residue of CD98HC eliminates its transforming activity.

Int. J. Cancer, 87(3) 311-316, 2000

200000
Sgs1 helicase activity is required for mitotic but apparently not for meiotic functions.

Mol. Cell. Biol., 20(17) 6399-6409, 2000

200000
Covalent modification of the Werner's syndrome gene product with the ubiquitin-related protein, SUMO-1.

J. Biol. Chem., 275(28) 20963-20966, 2000

200000
Colocalization of GP125/CD98 with tropomyosin isoforms at the cell-cell adhesion boundary

Takao Shishido, Mayumi Ohkawa, Akihiro Itoh, Takemi Enomoto, Yoshiyuki Hashimoto, Takashi Masuko

Journal of Biochemistry, 127(2) 253-261, 2000
Possible association of BLM in decreasing DNA double strand breaks during DNA replication.

EMBO J., 19(13) 3428-3435, 2000

200000
Malignant transformation of NIH3T3 cells by overexpression of early lymphocyte activation antigen CD98.

Hara, K, Kudoh, H, nomoto, T, Hashimoto, Y, Masuko, T

Biochem. Biophys. Res. Commun., 262(3) 720-725, 1999

199900
Identification of truncated human glutamate transporter.

Matsumoto, Y, nomoto, T, Masuko, T

Tohoku J. Exp. Med., 187(2) 173-182, 1999

199900
Identification and immunological characterization of a novel 40-kDa protein linked to CD98 antigen.

Matsumoto, Y, Satoh-Ueno, K, Yoshimura, A, Hashimoto, Y, nomoto, T, Masuko, T

Cell Struct. Funct., 24(4) 217-226, 1999

199900
Detection by epitope-defined monoclonal antibodies of Werner DNA helicases in the nucleoplasm and their upregulation by cell transformation and immortalization.

Shiratori, M, Sakamoto, S, Suzuki, N, Tokutake, Y, Kawabe, Y, nomoto, T, Sugimoto, M, Goto, M, Matsumoto, T, Furuichi, Y

J. Cell Biol., 144(1) 1-9, 1999

199900
Malignant transformation of NIH3T3 cells by overexpression of early lymphocyte activation antigen CD98.

Biochem. Biophys. Res. Commun., 262(3) 720-725, 1999

199900
Identification of truncated human glutamate transporter.

Tohoku J. Exp. Med., 187(2) 173-182, 1999

199900
Identification and immunological characterization of a novel 40-kDa protein linked to CD98 antigen.

Cell Struct. Funct., 24(4) 217-226, 1999

199900
Detection by epitope-defined monoclonal antibodies of Werner DNA helicases in the nucleoplasm and their upregulation by cell transformation and immortalization.

J. Cell Biol., 144(1) 1-9, 1999

199900
Cloning of two isoforms of mouse DNA helicase Q1/RecQl cDNA; α form is expressed ubiquitously and β form specifically in the testis

Wen-Sheng Wang, Masayuki Seki, Tomoki Yamaoka, Takahiko Seki, Shusuke Tada, Toshiaki Katada, Hirokazu Fujimoto, Takemi Enomoto

Biochimica et Biophysica Acta - Gene Structure and Expression, 1443(1-2) 198-202, Nov 26, 1998
cDNA cloning of mouse BLM gene, the homologue to human Bloom's syndrome gene, which is highly expressed in the testis at the mRNA level

Takahiko Seki, Wen-Sheng Wang, Natsuko Okumura, Masayuki Seki, Toshiaki Katada, Takemi Enomoto

Biochimica et Biophysica Acta - Gene Structure and Expression, 1398(3) 377-381, Jul 9, 1998
Isolation of a cDNA encoding mouse DNA topoisomerase III which is highly expressed at the mRNA level in the testis

Takahiko Seki, Masayuki Seki, Toshiaki Katada, Takemi Enomoto

Biochimica et Biophysica Acta - Gene Structure and Expression, 1396(2) 127-131, Mar 9, 1998
Cloning of cDNA encoding a novel mouse DNA topoisomerase III (Topo III β ) possessing negatively supercoiled DNA relaxing activity, whose message is highly expressed in the testis.

Seki, T, Sek,i M, Onodera, R, Katada, T, nomoto, T

J. Biol. Chem., 273(44) 28553-28556, 1998

199800
Cloning of a cDNA encoding a novel importin-alpha homologue, Qip1: Discrimination of Qip1 and Rch1 from hSrp1 by their ability to interact with DNA helicase Q1/RecQL

T Seki, S Tada, T Katada, T Enomoto

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 234(1) 48-53, May, 1997
Differential modes of nuclear localization signal (NLS) recognition by three distinct classes of NLS receptors.

Miyamoto, Y, Imamoto, N, Sekimoto, T, Tachibana, T, Seki, T, Tada, S, nomoto, T, Yoneda, Y

J. Biol. Chem., 272(42) 26375-26381, 1997

199700
Changes in composition of newly synthesized sphingolipids of HeLa cells during the cell cycle: Suppression of sphingomyelin and higher-glycosphingolipid synthesis and accumulation of ceramide and glucosylceramide in mitotic cells.

Yokoyama, K, Suzuki, M, Kawashima, I, Karasawa, K, Nojima, S, nomoto, T, Tai, T, Suzuki, A, Setaka, M

Eur. J. Biochem., 249(2) 450-455, 1997

199700
Differential modes of nuclear localization signal (NLS) recognition by three distinct classes of NLS receptors.

J. Biol. Chem., 272(42) 26375-26381, 1997

199700
Changes in composition of newly synthesized sphingolipids of HeLa cells during the cell cycle: Suppression of sphingomyelin and higher-glycosphingolipid synthesis and accumulation of ceramide and glucosylceramide in mitotic cells.

Eur. J. Biochem., 249(2) 450-455, 1997

199700
Phosphorylation-independent stimulation of DNA topoisomerase II alpha activity.

Kimura, K, Saijo, M, Tanaka, M, nomoto, T

J. Biol. Chem., 271(18) 10990-10995, 1996

199600
Characterization of the properties of a human homologue of Escherichia coli RecQ from xeroderma pigmentosum group C and from HeLa cells.

Tada, S, Yanagisawa, J, Sonoyama,T, Miyajima, .A, Seki, M, Ui, M, nomoto, T

Cell Struct. Funct., 21(2) 123-132, 1996

199600
Analysis of M phase-specific phosphorylation of DNA topoisomerase II.

Kimura, K, Nozaki, N, nomoto, T, Tanaka, M, Kikuchi, A

J. Biol. Chem., 271(35) 21439-21445, 1996

199600
Phosphorylation-independent stimulation of DNA topoisomerase II alpha activity.

J. Biol. Chem., 271(18) 10990-10995, 1996

199600
Characterization of the properties of a human homologue of Escherichia coli RecQ from xeroderma pigmentosum group C and from HeLa cells.

Cell Struct. Funct., 21(2) 123-132, 1996

199600
Analysis of M phase-specific phosphorylation of DNA topoisomerase II.

J. Biol. Chem., 271(35) 21439-21445, 1996

199600
Stimulation of mouse DNA primase-catalyzed oligoribonucleotide synthesis by mouse DNA helicase B

Akiko Saitoh, Shusuke Tada, Toshiaki Katada, Takemi Enomoto

Nucleic Acids Research, 23(11) 2014-2018, Jun 11, 1995
STIMULATION OF MOUSE DNA PRIMASE-CATALYZED OLIGORIBONUCLEOTIDE SYNTHESIS BY MOUSE DNA HELICASE-B

A SAITOH, S TADA, T KATADA, T ENOMOTO

NUCLEIC ACIDS RESEARCH, 23(11) 2014-2018, Jun, 1995
STIMULATION OF DNA-SYNTHESIS BY MOUSE DNA HELICASE-B IN A DNA-REPLICATION SYSTEM CONTAINING EUKARYOTIC REPLICATION ORIGINS

K MATSUMOTO, M SEKI, C MASUTANI, S TADA, T ENOMOTO, Y ISHIMI

BIOCHEMISTRY, 34(24) 7913-7922, Jun, 1995

Books and Other Publications

14

生物系薬学IV 演習編

東京化学同人, Jun, 2011
生物系薬学II 第２版

東京化学同人, Dec, 2010
生物系薬学II 日本薬学会編

東京化学同人

200500
Molecular mechanism of Werner's syndrome edited by Michel Lebel Kluwer Academic

Plenum Publishers, New York,

200400
廣川タンパク質化学第４巻酵素福井哲也、伊藤正樹編

廣川書店

200300

Presentations

601

Optimization of intracellular reactive oxygen species levels by antioxidant proteins in vertebrate cells

Sugahara Memorial International Symposium, 2012
損傷乗り越え合成におけるWRNIP1とDNA polymerase etaの機能的関連の解析

日本薬学会第132年会北海道大学札幌市, 2012
システムバイオロジーの構築を指向した新戦略：FD-LC-MS/MS法の活用

日本薬学会第132年会北海道大学札幌市, 2012
Optimization of intracellular reactive oxygen species levels by antioxidant proteins in vertebrate cells

Sugahara Memorial International Symposium, 2012
Antioxidant protein, either SOD1, SOD2 or PRDX1 is required for normal cell growth in vertebrate cells.

Gordon Research Conference; Oxidative Stress and Disease Ventura CA USA, 2011

Professional Memberships

7

Works

56

Research Projects

2

新たなDNA修復、組み換え機構及びその発生学的役割

1995 - 1996
Novel mechanism and developmental roles of repair recombination

1995 - 1996

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