ENOMOTO TAKEMI

(榎本武美)

Profile Information

Affiliation: Professor, Musashino University

Degree: 学士(東京大学)
修士(東京大学)
博士(東京大学)

J-GLOBAL ID: 200901056088076439
researchmap Member ID: 1000183964

Research Interests

Research Areas

Life sciences / Molecular biology /

Research History

Education

- 1981

アルバートアインシュタイン医科大学
- 1975

The University of Tokyo
- 1975

Graduate School, Division of Pharmaceutical Sciences, The University of Tokyo
- 1972

The University of Tokyo
- 1972

Graduate School, Division of Pharmaceutical Sciences, The University of Tokyo

Misc.

267

WRNIP1 accumulates at laser light irradiated sites rapidly via its ubiquitin-binding zinc finger domain and independently from its ATPase domain

Hironoshin Nomura, Akari Yoshimura, Takato Edo, Shin-ichiro Kanno, Syusuke Tada, Masayuki Seki, Akira Yasui, Takemi Enomoto

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 417(4) 1145-1150, Jan, 2012
Nucleosome surface containing nucleosomal DNA entry/exit site regulates H3-K36me3 via association with RNA polymerase II and Set2

Hirohito Endo, Yu Nakabayashi, Satoshi Kawashima, Takemi Enomoto, Masayuki Seki, Masami Horikoshi

GENES TO CELLS, 17(1) 65-81, Jan, 2012
Embryonic Lethality in Mice Lacking Mismatch-Specific Thymine DNA Glycosylase Is Partially Prevented by DOPS, a Precursor of Noradrenaline

Yusuke Saito, Tetsuya Ono, Naoki Takeda, Takehiko Nohmi, Masayuki Seki, Takemi Enomoto, Tetsuo Noda, Yoshihiko Uehara

TOHOKU JOURNAL OF EXPERIMENTAL MEDICINE, 226(1) 75-83, Jan, 2012
Roles of histone chaperone CIA/Asf1 in nascent DNA elongation during nucleosome replication

Katsuyuki Ishikawa, Tatsuya Ohsumi, Shusuke Tada, Ryo Natsume, Lena Rani Kundu, Naohito Nozaki, Toshiya Senda, Takemi Enomoto, Masami Horikoshi, Masayuki Seki

GENES TO CELLS, 16(10) 1050-1062, Oct, 2011
Roles of histone chaperone CIA/Asf1 in nascent DNA elongation during nucleosome replication

Katsuyuki Ishikawa, Tatsuya Ohsumi, Shusuke Tada, Ryo Natsume, Lena Rani Kundu, Naohito Nozaki, Toshiya Senda, Takemi Enomoto, Masami Horikoshi, Masayuki Seki

GENES TO CELLS, 16(10) 1050-1062, Oct, 2011

Books and Other Publications

生物系薬学IV 演習編

東京化学同人, Jun, 2011
生物系薬学II 第２版

東京化学同人, Dec, 2010
生物系薬学II 日本薬学会編

東京化学同人

200500
Molecular mechanism of Werner's syndrome edited by Michel Lebel Kluwer Academic

Plenum Publishers, New York,

200400
廣川タンパク質化学第４巻酵素福井哲也、伊藤正樹編

廣川書店

200300

Presentations

601

Functional analysis of RecQL4 using RecQL4 mutated cells.

The 6th 3R Symposium Tsumagoi, 2008
Effects of deregulating Cdc6 during the initiation of DNA replication.

The 6th 3R Symposium Tsumagoi, 2008
Analyses of the role of budding yeast Rmi1, a member of the Sgs1-Top3 complex, in sister chromatid cohesion

The 6th 3R Symposium Tsumagoi, 2008
Accumulation of sumoylated Rad52 in checkpoint mutants

The 6th 3R Symposium Tsumagoi, 2008
Analysis of DNA replication checkpoint factor Claspin in vertebrate cells

2008
Functions of the Bloom syndrome responsible gene product in DNA replication and sister chromatid cohesion.

2008
WRNIP1 interacts with RAD18-RAD6 and competes with them in binding to replication fork like structure.

2008
Requisite conditions for sumoylation of Rad52 and enhancement of the modification in checkpoint mutants

BMB2008, 2008
Nascent DNA elongation is repressed by deregulated Cdt1 in Xenopus egg extracts.

BMB2008, 2008
Budding yeast Rmi1 (a member of the Sgs1-Top3 complex) and sister chromatid cohesion: what's the connection?

BMB2008, 2008
Systematic domain analyses of the second subunit of DNA polymerase delta, Pol31, revealed the importance of Mgs1 and Rad18/Rad5/Mms2 for the survival of novel pol31 mutants.

Gordon Research Conferences: Mammalian DNA Repair. Ventura, California, USA, 2007
アフリカツメガエル卵抽出液を用いたDNA再複製防止機構の解析

日本薬学会第127年会富山市, 2007
DNA二本鎖切断誘発時におけるDNA-PK複合体の機能解析

日本薬学会第127年会富山市, 2007
Gemininは再複製時における複製フォークの停止を抑制する

第40回日本発生生物学会第59回日本細胞生物学会合同大会福岡国際会議場（福岡市）, 2007
動原体構築におけるアクチン関連タンパク質Arp4の機能解析

第４回東北大学バイオサイエンスシンポジウム仙台国際センター, 2007
新規DNA再複製抑制機構の生化学的解析

第４回東北大学バイオサイエンスシンポジウム仙台国際センター, 2007
Possible role of yeast Saccharomyces cerevisiae Rmi1in sister chromatid cohesion.

2007
DNA複製ライセンス化因子Cdc6によるDNA複製開始の抑制

第４回東北大学バイオサイエンスシンポジウム仙台国際センター, 2007
DNA-PK複合体を介したアポトーシスの解析

第４回東北大学バイオサイエンスシンポジウム仙台国際センター, 2007
Biochemical analyses to prevent chromosome rereplication.

2007
Cdc6 inhibits the initiation of DNA replication by modulating Cdc7-dependent hyperphosphorylation of Mcm4.

Cold Spring Harbor Laboratory Meeting on Eukaryotic DNA Replication and Genome Maintenance. Cold Spring Harbor Laboratory, New York, USA, 2007
Illegitimate activation of Cdt1 at S-phase possibly leads to a halt of nascent strand elongation in DNA re-replication.

2007
出芽酵母DNA polymerase δ Pol31サブユニットの機能ドメインの解析

第46回日本薬学会東北支部大会東北薬科大学（仙台市）, 2007
抗酸化酵素SOD2の転写on/off株の構築とその解析

第46回日本薬学会東北支部大会東北薬科大学（仙台市）, 2007
DNA複製ライセンス化因子Cdt1の生化学的機能に関する解析

第46回日本薬学会東北支部大会東北薬科大学（仙台市）, 2007
Cdc6によるDNA複製開始の制御

第46回日本薬学会東北支部大会東北薬科大学（仙台市）, 2007
出芽酵母DNA polymerase δ Pol31サブユニットの機能ドメインの解析

第30回日本分子生物学会年会・第80回日本生化学会大会合同大会パシフィコ横浜, 2007
ニワトリDT40細胞を用いた抗酸化酵素遺伝子破壊株の解析

第30回日本分子生物学会年会・第80回日本生化学会大会合同大会パシフィコ横浜, 2007
アクチン関連タンパク質Arp4の動原体構築における機能解析

第30回日本分子生物学会年会・第80回日本生化学会大会合同大会パシフィコ横浜, 2007
WRNIP1とRAD18の機能的連携の解明

第30回日本分子生物学会年会・第80回日本生化学会大会合同大会パシフィコ横浜, 2007
SUMO pathways and targets that ciunteract the accumulation of recombinogenic structures during DNA replication.

2007
Rmi1, a member of the Sgs1-Top3 complex in budding yeast, contributes to sister chromatid cohesion.

2007
Etoposide誘導性アポトーシスにおけるDNA-PKの機能解析

第30回日本分子生物学会年会・第80回日本生化学会大会合同大会パシフィコ横浜, 2007
DNA複製ライセンス化因子Cdt1の機能ドメインに関する生化学的解析

第30回日本分子生物学会年会・第80回日本生化学会大会合同大会パシフィコ横浜, 2007
Ctf18 is required for homologous recombination-mediated double strand break repair.

2007
Systematic domain analyses of the second subunit of DNA polymerase delta, Pol31, revealed the importance of Mgs1 and Rad18/Rad5/Mms2 for the survival of novel pol31 mutants.

Gordon Research Conferences: Mammalian DNA Repair. Ventura, California, USA, 2007
Possible role of yeast Saccharomyces cerevisiae Rmi1in sister chromatid cohesion.

2007
Biochemical analyses to prevent chromosome rereplication.

2007
Cdc6 inhibits the initiation of DNA replication by modulating Cdc7-dependent hyperphosphorylation of Mcm4.

Cold Spring Harbor Laboratory Meeting on Eukaryotic DNA Replication and Genome Maintenance. Cold Spring Harbor Laboratory, New York, USA, 2007
Illegitimate activation of Cdt1 at S-phase possibly leads to a halt of nascent strand elongation in DNA re-replication.

2007
Actin-related protein Arp4 functions in kinetochore assembly.

2007
SUMO pathways and targets that ciunteract the accumulation of recombinogenic structures during DNA replication.

2007
Rmi1, a member of the Sgs1-Top3 complex in budding yeast, contributes to sister chromatid cohesion.

2007
Ctf18 is required for homologous recombination-mediated double strand break repair.

2007
出芽酵母SOD1のDNA合成阻害剤HU処理時における機能の解析

日本薬学会第126年会仙台市, 2006
出芽酵母 Pol31 （Polδ のサブユニット）のドメインの解析

日本薬学会第126年会仙台市, 2006
アフリカツメガエル卵抽出液を用いたDNA複製開始におけるCdc6の機能解析

日本薬学会第126年会仙台市, 2006
アフリカツメガエル無細胞実験系を用いたブルーム症候群原因遺伝子産物BLMの挙動の解析

日本薬学会第126年会仙台市, 2006
The importance of Mgs1 and Rad18 for the survival of pol31 defective mutants revealed through systematic domain analyses of Pol31, the second subunit S. cerevisiae Pold.

2006
Rmi1/Nce4, a subunit of the Sgs1-Top3 complex, of Saccharomyces cerevisiae is involved in homologous recombination and establishment of sister chromatid cohesion.

2006

Professional Memberships

Works

Research Projects

新たなDNA修復、組み換え機構及びその発生学的役割

1995 - 1996
Novel mechanism and developmental roles of repair recombination

1995 - 1996

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