Researcher List Yasukazu Takanezawa Yasukazu Takanezawa (高根沢 康一) Please select the form format to download from below 「Education and research environment」format 「No. 4, the Ministry of Education document style ①Outline for Vitae」format 「No. 4, the Ministry of Education document style ②Education and research environment」format 「List of Teachers」format Profile Information AffiliationProfessor, School of Pharmacy, Faculty of Pharmacy, Musashino UniversityDegreePh.D(Mar, 2002, The University of Tokyo)Researcher number90345257ORCID ID https://orcid.org/0000-0002-9220-5825J-GLOBAL ID202001012207827457researchmap Member IDR000007558 Research Interests 5 オートファジー 有害金属 メチル水銀 環境汚染物質 Toxicology Research Areas 2 Life sciences / Cell biology / 有害金属 Life sciences / Pharmaceuticals - health and biochemistry / Research History 7 Nov, 2025 - Present Professor, Department of Pharmacy, Musashino University Apr, 2019 - Oct, 2025 School of Pharmaceutical Sciences, Kitasato University Apr, 2015 - Mar, 2019 School of Pharmaceutical Sciences, Kitasato University Sep, 2014 - Mar, 2015 School of Pharmaceutical Sciences, Kitasato University Apr, 2014 - Aug, 2014 Graduate School of Pharmaceutical Sciences, The University of Tokyo More Education 6 Mar, 2002 - Present Graduate School of Pharmaceutical Sciences, The University of Tokyo Mar, 1999 - Present 修士(薬学), 北里大学大学院 Mar, 1997 - Present Kitasato University Apr, 1999 - Mar, 2002 Graduate School of Pharmaceutical Sciences, The University of Tokyo Apr, 1997 - Mar, 1999 Graduate School of Pharmaceutical Sciences, Kitasato University More Papers 55 Tonoplast-targeted bacterial transporter MerC enhances cadmium tolerance in Arabidopsis via vacuolar sequestration and cytoplasmic protection Shimpei Uraguchi, Mikine Kimura, Yuka Ohshiro, Ryosuke Nakamura, Yasukazu Takanezawa, Masako Kiyono Plant Cell Reports, 44(7), Jul 5, 2025 Peer-reviewed The predominant role of p62/SQSTM1 over NBR1 in methylmercury-induced cytotoxicity and cellular defense Yasukazu Takanezawa, Kazuma Sakai, Ryosuke Nakamura, Yuka Ohshiro, Shimpei Uraguchi, Masako Kiyono Biochemical and Biophysical Research Communications, 151461-151461, Feb, 2025 Peer-reviewedLead authorCorresponding author Phenylmercury stress induces root tip swelling through auxin homeostasis disruption Shimpei Uraguchi, Masakazu Sato, Chihiro Hagai, Momoko Hirakawa, Kotomi Ogawa, Miyu Odagiri, Haruka Sato, Ayaka Ohmori, Yuka Ohshiro, Ryosuke Nakamura, Yasukazu Takanezawa, Masako Kiyono Plant Molecular Biology, 115(1), Dec 18, 2024 Peer-reviewed Oleanolic acid-3-glucoside, a synthetic oleanane-type saponin, ameliorates methylmercury-induced dysfunction of synaptic transmission in mice Ryosuke Nakamura, Takashi Iwai, Yasukazu Takanezawa, Tatsuya Shirahata, Naruki Konishi, Yuka Ohshiro, Shimpei Uraguchi, Mitsuo Tanabe, Yoshinori Kobayashi, Kenji Sakamoto, Tsutomu Nakahara, Megumi Yamamoto, Masako Kiyono Toxicology, 506 153867-153867, Aug, 2024 Peer-reviewed Root cell-type specific expressions of bacterial mercury transporter MerC and plant SNARE SYP121 fusion protein differentially affect cadmium accumulation patterns of Arabidopsis Shimpei Uraguchi, Yuka Ohshiro, Kaede Abe, Yuta Tsuchiya, Ryosuke Nakamura, Yasukazu Takanezawa, Masako Kiyono SOIL SCIENCE AND PLANT NUTRITION, Jul, 2023 Peer-reviewed More Misc. 37 Autophgy response to toxic metal exposure in SH-SY5Y neuroblastoma cells 大橋悠暉, 高根沢康一, 酒井和真, 中村亮介, 大城有香, 浦口晋平, 清野正子 衛生薬学・環境トキシコロジー講演要旨集, 2023, 2023 Effect of autophagy on methylmercury-induced lipid droplet formation and adipokine expression in 3T3-L1 cells 高根沢康一, 柏野結, 中村亮介, 大城有香, 浦口晋平, 清野正子 Journal of Toxicological Sciences, 48(Supplement (CD-ROM)), 2023 亜ヒ酸とカドミウム毒性に対するシロイヌナズナ根端分裂組織の応答の特異性 佐藤正和, 浦口晋平, 萬代麻衣, 大城有香, 中村亮介, 高根沢康一, 清野正子 日本土壌肥料学会講演要旨集(Web), 69, 2023 根端分裂組織のカドミウム・亜ヒ酸応答におけるNAC型転写因子ANAC044とANAC085の機能分化の可能性 浦口晋平, 山村有加, 菅谷翔, 佐藤正和, 大城有香, 中村亮介, 高根沢康一, 清野正子 日本土壌肥料学会講演要旨集(Web), 69, 2023 微生物由来の金属輸送体MerC多重発現シロイヌナズナの確立の試み 土屋佑太, 浦口晋平, 月岡輝璃, 西田翔, 大城有香, 中村亮介, 高根沢康一, 清野正子 日本土壌肥料学会講演要旨集(Web), 69, 2023 More Presentations 149 オートファジーが関与するメチル水銀結合タンパク質の細胞内動態の解析 高根沢 康一, 角田 麗衣, 中村 亮介, 大城 有香, 浦口 晋平, 清野 正子 フォーラム2025衛生薬学・環境トキシコロジー, Sep 10, 2025 オレアノール酸およびそのサポニン誘導体のメチル水銀毒性に対する保護効果 中村 亮介, 黒田 陽子, 大橋 生実, 白畑 辰弥, 小西 成樹, 高根沢 康一, 大城 有香, 浦口 晋平, 小林 義典, 清野 正子 フォーラム2025衛生薬学・環境トキシコロジー, Sep 10, 2025 水銀トランスポーターMerCの環境浄化への適応性 大城 有香, 浦口 晋平, 中村 亮介, 高根沢 康一, 清野 正子 フォーラム2025衛生薬学・環境トキシコロジー, Sep 10, 2025 The protective mechanism against methylmercury orchestrated by the p62/SQSTM1 Jul 3, 2025 メチル水銀毒性に対する有害金属曝露の影響 高根沢 康一, 須田 成海, 折茂 奈優, 中村 亮介, 大城 有香, 浦口 晋平, 清野 正子 日本薬学会第145年会, Mar 28, 2025 More Teaching Experience 6 2017 - Present 健康科学(北里大学薬学部) 2015 - Present 薬学総合演習(北里大学薬学部) 2014 - Present 衛生薬学特論 (北里大学薬学部) 2014 - Present 公衆衛生学実習 (北里大学薬学部) 2014 - Present 公衆衛生学II(北里大学薬学部) More Professional Memberships 3 日本生化学会 日本毒性学会 日本薬学会 Research Projects 8 p62/SQSTM1が介在するメチル水銀の脳内代謝と毒性制御機構の解明 重金属等による健康影響に関する総合的研究, 環境省, Apr, 2025 - Mar, 2028 清野正子, 高根沢康一, 中村亮介 The autophagy cargo receptor p62 and its mechanistic roles in methylmercury detoxication. Grants-in-Aid for Scientific Research, Japan Society for the Promotion of Science, Apr, 2022 - Mar, 2025 p62/SQSTM1欠損in vitroおよびin vivoモデル系を用いたメチル水銀毒性防御機構の解析 重金属等による健康影響に関する総合的研究, 環境省, Apr, 2022 - Mar, 2025 清野正子, 高根沢康一, 中村亮介 Analysis of toxic heavy metals in neurodegenerative disorders and evaluation of derivatives of oleanoic acid as a therapeutic candidate Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (C), Japan Society for the Promotion of Science, Apr, 2017 - Mar, 2020 Yasukazu Takanezawa Molecular breeding of Arabidopsis plants with cell-type specific promoters and a bacterial mercury transporter MerC Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (B), Japan Society for the Promotion of Science, Apr, 2015 - Mar, 2018 KIYONO MASAKO, TAKANEZAWA Yasukazu, URAGUCHI Shimpei, SONE Yuka, NAKAMURA Ryosuke More
Yasukazu Takanezawa (高根沢 康一) Please select the form format to download from below 「Education and research environment」format 「No. 4, the Ministry of Education document style ①Outline for Vitae」format 「No. 4, the Ministry of Education document style ②Education and research environment」format 「List of Teachers」format Profile Information AffiliationProfessor, School of Pharmacy, Faculty of Pharmacy, Musashino UniversityDegreePh.D(Mar, 2002, The University of Tokyo)Researcher number90345257ORCID ID https://orcid.org/0000-0002-9220-5825J-GLOBAL ID202001012207827457researchmap Member IDR000007558 Research Interests 5 オートファジー 有害金属 メチル水銀 環境汚染物質 Toxicology Research Areas 2 Life sciences / Cell biology / 有害金属 Life sciences / Pharmaceuticals - health and biochemistry / Research History 7 Nov, 2025 - Present Professor, Department of Pharmacy, Musashino University Apr, 2019 - Oct, 2025 School of Pharmaceutical Sciences, Kitasato University Apr, 2015 - Mar, 2019 School of Pharmaceutical Sciences, Kitasato University Sep, 2014 - Mar, 2015 School of Pharmaceutical Sciences, Kitasato University Apr, 2014 - Aug, 2014 Graduate School of Pharmaceutical Sciences, The University of Tokyo More Education 6 Mar, 2002 - Present Graduate School of Pharmaceutical Sciences, The University of Tokyo Mar, 1999 - Present 修士(薬学), 北里大学大学院 Mar, 1997 - Present Kitasato University Apr, 1999 - Mar, 2002 Graduate School of Pharmaceutical Sciences, The University of Tokyo Apr, 1997 - Mar, 1999 Graduate School of Pharmaceutical Sciences, Kitasato University More Papers 55 Tonoplast-targeted bacterial transporter MerC enhances cadmium tolerance in Arabidopsis via vacuolar sequestration and cytoplasmic protection Shimpei Uraguchi, Mikine Kimura, Yuka Ohshiro, Ryosuke Nakamura, Yasukazu Takanezawa, Masako Kiyono Plant Cell Reports, 44(7), Jul 5, 2025 Peer-reviewed The predominant role of p62/SQSTM1 over NBR1 in methylmercury-induced cytotoxicity and cellular defense Yasukazu Takanezawa, Kazuma Sakai, Ryosuke Nakamura, Yuka Ohshiro, Shimpei Uraguchi, Masako Kiyono Biochemical and Biophysical Research Communications, 151461-151461, Feb, 2025 Peer-reviewedLead authorCorresponding author Phenylmercury stress induces root tip swelling through auxin homeostasis disruption Shimpei Uraguchi, Masakazu Sato, Chihiro Hagai, Momoko Hirakawa, Kotomi Ogawa, Miyu Odagiri, Haruka Sato, Ayaka Ohmori, Yuka Ohshiro, Ryosuke Nakamura, Yasukazu Takanezawa, Masako Kiyono Plant Molecular Biology, 115(1), Dec 18, 2024 Peer-reviewed Oleanolic acid-3-glucoside, a synthetic oleanane-type saponin, ameliorates methylmercury-induced dysfunction of synaptic transmission in mice Ryosuke Nakamura, Takashi Iwai, Yasukazu Takanezawa, Tatsuya Shirahata, Naruki Konishi, Yuka Ohshiro, Shimpei Uraguchi, Mitsuo Tanabe, Yoshinori Kobayashi, Kenji Sakamoto, Tsutomu Nakahara, Megumi Yamamoto, Masako Kiyono Toxicology, 506 153867-153867, Aug, 2024 Peer-reviewed Root cell-type specific expressions of bacterial mercury transporter MerC and plant SNARE SYP121 fusion protein differentially affect cadmium accumulation patterns of Arabidopsis Shimpei Uraguchi, Yuka Ohshiro, Kaede Abe, Yuta Tsuchiya, Ryosuke Nakamura, Yasukazu Takanezawa, Masako Kiyono SOIL SCIENCE AND PLANT NUTRITION, Jul, 2023 Peer-reviewed More Misc. 37 Autophgy response to toxic metal exposure in SH-SY5Y neuroblastoma cells 大橋悠暉, 高根沢康一, 酒井和真, 中村亮介, 大城有香, 浦口晋平, 清野正子 衛生薬学・環境トキシコロジー講演要旨集, 2023, 2023 Effect of autophagy on methylmercury-induced lipid droplet formation and adipokine expression in 3T3-L1 cells 高根沢康一, 柏野結, 中村亮介, 大城有香, 浦口晋平, 清野正子 Journal of Toxicological Sciences, 48(Supplement (CD-ROM)), 2023 亜ヒ酸とカドミウム毒性に対するシロイヌナズナ根端分裂組織の応答の特異性 佐藤正和, 浦口晋平, 萬代麻衣, 大城有香, 中村亮介, 高根沢康一, 清野正子 日本土壌肥料学会講演要旨集(Web), 69, 2023 根端分裂組織のカドミウム・亜ヒ酸応答におけるNAC型転写因子ANAC044とANAC085の機能分化の可能性 浦口晋平, 山村有加, 菅谷翔, 佐藤正和, 大城有香, 中村亮介, 高根沢康一, 清野正子 日本土壌肥料学会講演要旨集(Web), 69, 2023 微生物由来の金属輸送体MerC多重発現シロイヌナズナの確立の試み 土屋佑太, 浦口晋平, 月岡輝璃, 西田翔, 大城有香, 中村亮介, 高根沢康一, 清野正子 日本土壌肥料学会講演要旨集(Web), 69, 2023 More Presentations 149 オートファジーが関与するメチル水銀結合タンパク質の細胞内動態の解析 高根沢 康一, 角田 麗衣, 中村 亮介, 大城 有香, 浦口 晋平, 清野 正子 フォーラム2025衛生薬学・環境トキシコロジー, Sep 10, 2025 オレアノール酸およびそのサポニン誘導体のメチル水銀毒性に対する保護効果 中村 亮介, 黒田 陽子, 大橋 生実, 白畑 辰弥, 小西 成樹, 高根沢 康一, 大城 有香, 浦口 晋平, 小林 義典, 清野 正子 フォーラム2025衛生薬学・環境トキシコロジー, Sep 10, 2025 水銀トランスポーターMerCの環境浄化への適応性 大城 有香, 浦口 晋平, 中村 亮介, 高根沢 康一, 清野 正子 フォーラム2025衛生薬学・環境トキシコロジー, Sep 10, 2025 The protective mechanism against methylmercury orchestrated by the p62/SQSTM1 Jul 3, 2025 メチル水銀毒性に対する有害金属曝露の影響 高根沢 康一, 須田 成海, 折茂 奈優, 中村 亮介, 大城 有香, 浦口 晋平, 清野 正子 日本薬学会第145年会, Mar 28, 2025 More Teaching Experience 6 2017 - Present 健康科学(北里大学薬学部) 2015 - Present 薬学総合演習(北里大学薬学部) 2014 - Present 衛生薬学特論 (北里大学薬学部) 2014 - Present 公衆衛生学実習 (北里大学薬学部) 2014 - Present 公衆衛生学II(北里大学薬学部) More Professional Memberships 3 日本生化学会 日本毒性学会 日本薬学会 Research Projects 8 p62/SQSTM1が介在するメチル水銀の脳内代謝と毒性制御機構の解明 重金属等による健康影響に関する総合的研究, 環境省, Apr, 2025 - Mar, 2028 清野正子, 高根沢康一, 中村亮介 The autophagy cargo receptor p62 and its mechanistic roles in methylmercury detoxication. Grants-in-Aid for Scientific Research, Japan Society for the Promotion of Science, Apr, 2022 - Mar, 2025 p62/SQSTM1欠損in vitroおよびin vivoモデル系を用いたメチル水銀毒性防御機構の解析 重金属等による健康影響に関する総合的研究, 環境省, Apr, 2022 - Mar, 2025 清野正子, 高根沢康一, 中村亮介 Analysis of toxic heavy metals in neurodegenerative disorders and evaluation of derivatives of oleanoic acid as a therapeutic candidate Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (C), Japan Society for the Promotion of Science, Apr, 2017 - Mar, 2020 Yasukazu Takanezawa Molecular breeding of Arabidopsis plants with cell-type specific promoters and a bacterial mercury transporter MerC Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (B), Japan Society for the Promotion of Science, Apr, 2015 - Mar, 2018 KIYONO MASAKO, TAKANEZAWA Yasukazu, URAGUCHI Shimpei, SONE Yuka, NAKAMURA Ryosuke More