Journal of pharmacological sciences 136(1) 39-41 2018年1月
Oseltamivir has a hypothermic effect in mice when injected intraperitoneally (i.p.) and intracerebroventricularly (i.c.v.). Here we show that the hypothermia evoked by i.c.v.-oseltamivir is inhibited by non-selective dopamine receptor antagonists ...
Acetaminophen (AcAP), a widely-used antipyretic and analgesic drug, has been considered to exert its effects via central mechanisms, and many studies have demonstrated that the analgesic action of AcAP involves activation of the serotonergic syste...
EUROPEAN JOURNAL OF PHARMACOLOGY 793 66-75 2016年12月 [査読有り]
Cilnidipine is a dihydropyridine derivative that inhibits N-type and L-type voltage-gated Ca2+ channels (VDCCs). We recently reported that a selective N-type VDCC blocker attenuated the spinal long-term potentiation (LTP) of C-fiber-evoked field p...
Shohei Yamamoto   Hideki Ono   Kazuhiko Kume   Masahiro Ohsawa   
JOURNAL OF PHARMACOLOGICAL SCIENCES 130(4) 189-193 2016年4月 [査読有り]
Oxaliplatin (L-OHP) is a platinum-based chemotherapy drug, used in standard treatment of colorectal cancer. L-OHP frequently causes acute peripheral neuropathies. These adverse effects limit cancer therapy with L-OHP. The present study was designe...
EUROPEAN JOURNAL OF PHARMACOLOGY 762(5) 275-282 2015年9月 [査読有り]
Oseltamivir, an anti-influenza virus drug, induces marked hypothermia in normal mice. We have proposed that the hypothermic effect arises from inhibition of the nicotinic acetylcholine receptor function of sympathetic ganglion neurons which innerv...
Masahiro Ohsawa   Shohei Yamamoto   Hideki Ono   
YAKUGAKU ZASSHI-JOURNAL OF THE PHARMACEUTICAL SOCIETY OF JAPAN 134(3) 387-395 2014年3月
Central sensitization in the spinal cord is well known to be involved in chronic pain. Recent investigations indicated that the protein expressions involving the synaptic plasticity are changed in several brain areas under a chronic pain condition...