研究者氏名	渡邊幸子
	ワタナベサチコ
URL	https://kaken.nii.ac.jp/ja/search/?qm=80770619
所属	武蔵野大学
部署	薬学部薬学科
職名	助教
学位	理学博士(北里大学)
科研費研究者番号	80770619
J-Global ID	201601011762460322

研究分野

ライフサイエンス / 免疫学 /

経歴

2021年4月

現在

武蔵野大学薬学部薬学科助教

2016年3月

2019年9月

自治医科大学炎症・免疫研究部助教

2016年2月

京都大学医学研究科

学歴

2008年4月

2013年3月

北里大学大学院理学研究科

論文

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Lipoteichoic Acid Inhibits Lipopolysaccharide-Induced TLR4 Signaling by Forming an Inactive TLR4/MD-2 Complex Dimer

Sachiko Watanabe Kosuke Zenke Masashi Muroi

The Journal of Immunology 2023年3月 [査読有り]

Abstract

LPS interacts with TLR4, which play important roles in host-against-pathogen immune responses, by binding to MD-2 and inducing an inflammatory response. In this study, to our knowledge, we found a novel function of lipoteichoic acid (LT...

Minimal structure of IRAK-1 to induce degradation of TRAF6

Sachiko Watanabe Kosuke Zenke Yuka Sugiura Masashi Muroi

Immunobiology 227(5) 152256-152256 2022年9月 [査読有り]

Excessive activation of Toll-like receptor (TLR) leads to sepsis. Inflammatory responses to various microbiological components are initiated via different TLR proteins, but all TLR signals are transmitted by TRAF6. We reported that TRAF6 associate...

Cryo-sensitive aggregation triggers NLRP3 inflammasome assembly in cryopyrin-associated periodic syndrome.

Tadayoshi Karasawa Takanori Komada Naoya Yamada Emi Aizawa Yoshiko Mizushina Sachiko Watanabe Chintogtokh Baatarjav Takayoshi Matsumura Masafumi Takahashi

eLife 11 2022年5月 [査読有り]

Cryopyrin-associated periodic syndrome (CAPS) is an autoinflammatory syndrome caused by mutations of NLRP3 gene encoding cryopyrin. Familial cold autoinflammatory syndrome, the mildest form of CAPS, is characterized by cold-induced inflammation in...

ASC regulates platelet activation and contributes to thrombus formation independent of NLRP3 inflammasome.

Sachiko Watanabe Fumitake Usui-Kawanishi Takanori Komada Tadayoshi Karasawa Ryo Kamata Naoya Yamada Hiroaki Kimura Katsuya Dezaki Tsukasa Ohmori Masafumi Takahashi

Biochemical and biophysical research communications 531(2) 125-132 2020年10月 [査読有り]

BACKGROUND: Platelets are critical mediators of vascular homeostasis and thrombosis, and also contribute to the development of inflammation. NLRP3 inflammasome is a cytosolic multi-protein complex that consists of NLRP3, ASC and caspase-1, and reg...

Glucose regulates hypoxia-induced NLRP3 inflammasome activation in macrophages.

Sachiko Watanabe Fumitake Usui-Kawanishi Tadayoshi Karasawa Hiroaki Kimura Ryo Kamata Takanori Komada Yoshiyuki Inoue Nathan Mise Tadashi Kasahara Masafumi Takahashi

Journal of cellular physiology 235(10) 7554-7566 2020年10月 [査読有り]

Although the intimate linkage between hypoxia and inflammation is well known, the mechanism underlying this linkage has not been fully understood. Nucleotide-binding oligomerization domain-like receptor (NLR) family pyrin domain containing 3 (NLRP...