薬科学専攻（修士課程） - 武蔵野大学教員情報

研究分野

ライフサイエンス / 免疫学 /

経歴

2020年4月

-

現在

武蔵野大学薬学部免疫生化学教室講師

2018年6月

-

2020年3月

武蔵野大学薬学部免疫生化学教室助教

2017年4月

-

2018年5月

順天堂大学環境医学研究所日本学術振興会特別研究員(RPD)

2015年5月

-

2017年3月

順天堂大学環境医学研究所研究支援者

2010年6月

-

2013年10月

米国国立衛生研究所博士研究員

論文

<1 2 3 45

IL-17A produced by gammadelta T cells plays a critical role in innate immunity against listeria monocytogenes infection in the liver.

Satoru Hamada Masayuki Umemura Takeru Shiono Kensho Tanaka Ayano Yahagi M Dilara Begum Kiyotetsu Oshiro Yuko Okamoto Hisami Watanabe Kazuyoshi Kawakami Christina Roark Willi K Born Rebecca O'Brien Koichi Ikuta Hiromichi Ishikawa Susumu Nakae Yoichiro Iwakura Takao Ohta Goro Matsuzaki

Journal of immunology (Baltimore, Md. : 1950) 181(5) 3456-63 2008年9月 [査読有り]

IL-17A is originally identified as a proinflammatory cytokine that induces neutrophils. Although IL-17A production by CD4(+) Th17 T cells is well documented, it is not clear whether IL-17A is produced and participates in the innate immune response...

Human Th1 differentiation induced by lipoarabinomannan/lipomannan from Mycobacterium bovis BCG Tokyo-172.

Toshihiro Ito Akihiro Hasegawa Hiroyuki Hosokawa Masakatsu Yamashita Shinichiro Motohashi Takashi Naka Yuko Okamoto Yukiko Fujita Yasuyuki Ishii Masaru Taniguchi Ikuya Yano Toshinori Nakayama

International immunology 20(7) 849-60 2008年7月 [査読有り]

Mycobacterium tuberculosis (tubercle bacilli) and the related acid-fast bacteria including Mycobacterium bovis Bacille Calmett-Guerin (BCG) have a characteristic cell wall (CW) containing various lipoglycans and glycolipids. Such lipoglycans have ...

Mucosal immunization with recombinant heparin-binding haemagglutinin adhesin suppresses extrapulmonary dissemination of Mycobacterium bovis bacillus Calmette-Guérin (BCG) in infected mice.

Hideyasu Kohama Masayuki Umemura Yuko Okamoto Ayano Yahagi Haruhisa Goga Tetsuya Harakuni Goro Matsuzaki Takeshi Arakawa

Vaccine 26(7) 924-32 2008年2月 [査読有り]

It is generally accepted that cellular immunity plays a critical role in the protection against Mycobacterium tuberculosis, an intracellular pathogen. Recently, however, an increasing number of reports indicate the important contribution of humora...

Molecular and supra-molecular structure related differences in toxicity and granulomatogenic activity of mycobacterial cord factor in mice.

Yukiko Fujita Yuko Okamoto Yuko Uenishi Makoto Sunagawa Takehiko Uchiyama Ikuya Yano

Microbial pathogenesis 43(1) 10-21 2007年7月 [査読有り]

To establish the structure biological activity relationship of cord factor (trehalose 6,6'-dimycolate, TDM), we compared the molecular or supra-molecular structure of TDM micelles with toxicity, thymic atrophy and granulomatogenicity in lungs and ...

Mycobacterial sulfolipid shows a virulence by inhibiting cord factor induced granuloma formation and TNF-alpha release.

Yuko Okamoto Yukiko Fujita Takashi Naka Manabu Hirai Ikuko Tomiyasu Ikuya Yano

Microbial pathogenesis 40(6) 245-53 2006年6月 [査読有り]

Virulence mechanism of infection with Mycobacterium tuberculosis is currently focused to be clarified in the context of cell surface lipid molecule. Comparing two mycobacterial glycolipids, we observed toxicity and prominent granulomatogenic activ...