Pregabalin, a useful drug for neuropathic pain, has a high incidence of dizziness and somnolence as side effects. In the present study, the incidence of both side effects and the risk factors were retrospectively investigated in hospitalized patie...
Minami Ohara   Harumi Takahashi   Ming Ta Michael Lee   Ming-Shien Wen   Tsong-Hai Lee   Hui-Ping Chuang   Chen-Hui Luo   Aki Arima   Akiko Onozuka   Rui Nagai   Mari Shiomi   Kiyoshi Mihara   Takashi Morita   Yuan-Tsong Chen   
PLoS One 9(8) 2014年8月 [査読有り]
To clarify pharmacokinetic-pharmacodynamic (PK-PD) factors associated with the over-anticoagulation response in Asians during warfarin induction therapy, population PK-PD analyses were conducted in an attempt to predict the time-courses of the pla...
Drug Metabolism and Pharmacokinetics 27(3) 280-285 2012年6月 [査読有り]
Establishment of in vitro in vivo correlation (IVIVC) accelerates optimization of desirable drug formulations and/or modification of the manufacturing processes in the scale-up and post-approval periods. This article presents a method of finding t...