Dissolution testing is useful for controlling the quality of oral products and rejecting bioinequivalent products. However, several sources of variability in dissolution tests can affect evaluations of quality. The purpose of this study was to inv...
Drug Metabolism and Disposition 36(10) 2037-2042 2008年10月 [査読有り]
Verapamil (VP) is used as a racemate but shows stereoselective pharmacokinetics and pharmacodynamics. It undergoes extensive first-pass metabolism. Stereoselective first-pass metabolism in the intestine and liver was investigated in vivo and in vi...
Journal of chromatography B, Analytical Technologies in the Biomedical and Life Sciences 843(1) 73-77 2006年10月 [査読有り]
A highly sensitive HPLC method for enantioselective determination of carvedilol inhuman whole blood and plasma was developed. Carvedilol and S-carazolol as an internal standard extracted from whole blood or plasma were separated using an enantiose...
Journal of Clinical Pharmacology 46(1) 59-68 2006年1月 [査読有り]
Population pharmacokinetics (PK) of a sodium channel-blocking antiarrhythmic, pilsicainide, was studied using the nonlinear mixed-effects modeling technique in 91 patients with cardiac arrhythmias (80 suspected Brugada syndrome [BrS] and 11 with a...
Therapeutic Drug Monitoring 27(1) 18-24 2005年2月 [査読有り]
The validity of pharmacokinetic parameters estimated by the maximum a posteriori probability (MAP) Bayesian method was investigated by simulation studies. A 1-compartment model with bolus intravenous administration was used as a pharmacokinetic mo...