Pharmaceutical Research 15(8) 1250-1256 1998年8月 [査読有り]
Purpose, The stereoselective distribution of three basic drugs, disopyramide (DP), flecainide (FLC) and verapamil (VP), was studied to clarify the relationships between the tissue-to-unbound plasma concentration ratio (Kpf) and drug lipophilicity ...
We studied the inhibition of S-warfarin metabolism by nonsteroidal antiinflammatory drugs (NSAIDs) in human liver microsomes in vitro. After screening for potential inhibitors among ten NSAIDs using human recombinant cytochrome P450, inhibition ki...
Journal of Chromatography B: Biomedical Sciences and Applications 709(2) 315-319 1998年5月 [査読有り]
A simple and practical high-performance liquid chromatographic analysis has been developed for measuring teniposide (VM26) in human plasma. The present analytical method has improved extraction efficiency from human plasma, therefore allowing dete...
The renal disposition characteristics of superoxide dismutase (SOD) and its derivatives, including macromolecular conjugates with polyethylene glycol and carboxymethyl-dextran, a cationized derivative, and glycosylated derivatives with galactose a...
K Mihara   Y Oka   K Sawai   Y Takakura   M Hashida   
Journal of Drug Targeting 2(4) 317-321 1994年 [査読有り]
Therapeutic effect of superoxide dismutase (SOD) and three derivatives: a conjugate with polyethylene glycol (SOD-PEG(2)), a cationized derivative (cSOD), and a mannosylated derivative (Man-SOD), on acute renal failure induced by ischemia/reperfus...