Journal of Controlled Release 28(1-3) 111-119 1994年1月 [査読有り]
To construct the strategy to control the renal disposition profiles of protein drugs by chemical modification, studies were performed using the perfused rat kidney. Renal disposition processes, i.e., glomerular filtration, tubular reabsorption, an...
Pharmaceutical Research 10(6) 823-827 1993年6月 [査読有り]
The renal disposition characteristics of In-111-labeled neocarzinostatin (NCS), soybean trypsin inhibitor (STI), and superoxide dismutase (SOD) were studied in the perfused rat kidney. In a single-pass indicator dilution experiment, venous and uri...
The disposition characteristics of model macromolecules such as dextran (70 kDa), bovine serum albumin (BSA), and their charged derivatives were studied in the perfused rat kidney. In a single-pass indicator dilution experiment, venous and urinary...
Pharmaceutical Research 8(4) 437-444 1991年4月 [査読有り]
The effect of electric charge on the hepatic disposition of macromolecules was studied in the rat. Charged derivatives of dextran (T-70) and bovine serum albumin (BSA), mitomycin C-dextran conjugates (MMC-D), and lactosaminated BSA (Lac-BSA) were ...