Chemical & Pharmaceutical Bulletin Vol.66(No.7) 714-720 2018年5月 [査読有り]
We previously found that antioxidative activity of liposomes co-encapsulating astaxanthin (Asx) and tocotrienols (T3s) was higher than the calculated additive activity, which results from intermolecular interactions between both antioxidants (J. C...
Delivery of anticancer drugs into tumor cores comprised of malignant cancer cells can result in potent therapeutic effects. However, conventional nanoparticle-based drug delivery systems used for cancer therapy often exhibit inefficient tumor-pene...
Hyunkyung Jung   Yuri Shimatani   Mahadi Hasan   Kohei Uno   Susumu Hama   Kentaro Kogure   
INTERNATIONAL JOURNAL OF PHARMACEUTICS 516(1-2) 258-265 2017年1月 [査読有り]
Various non-viral delivery systems for small interfering RNAs (siRNA) have been developed. Such delivery systems generally exhibit tightly formed spherical structures. While such carriers have demonstrated good transfection activity in mono-layere...
Biological and Pharmaceutical Bulletin 40(6) 941-944 2017年 [査読有り]
UV rays induce melanin production in the skin, which, from a cosmetic point of view, is problematic. Reactive oxygen species (ROS) generated in the skin upon UV irradiation are thought to be responsible for melanin production. Thus, effective anti...
JOURNAL OF CLINICAL BIOCHEMISTRY AND NUTRITION 59(2) 100-106 2016年9月 [査読有り]
Astaxanthin and vitamin E are both effective antioxidants that are frequently used in cosmetics, as food additives, and in to prevent oxidative damage. A combination of astaxanthin and vitamin E would be expected to show an additive anntioxidative...