INTERNATIONAL JOURNAL OF PHARMACEUTICS 383(1-2) 157-160 2010年1月 [査読有り]
Topical application of siRNA to the skin should be an effective treatment for serious skin disorders, such as atopic dermatitis. However, it is difficult to introduce hydrophilic macromolecules including siRNA, into the skin by conventional method...
This study describes a multifunctional envelope-type nano device (MEND) that mimics an envelope-type virus based on a novel packaging strategy. MEND particles contain a DNA core packaged into a lipid envelope modified with an octaarginine peptide....
NUCLEIC ACIDS RESEARCH 35(5) 1533-1543 2007年 [査読有り]
Quantitative and mechanism-based information on differences in transfection efficiency between viral and non-viral vectors would be highly useful for improving the effectiveness of non-viral vectors. A previous quantitative comparison of intracell...
S Hama   H Akita   R Ito   H Mizuguchi   T Hayakawa   H Harashima   
MOLECULAR THERAPY 13(4) 786-794 2006年4月 [査読有り]
To develop nonviral gene vectors that are sufficient for clinical application, it is necessary to understand why and to what extent nonviral vectors are inferior to viral vectors, which in general show a more efficient transfection activity. This ...