The natural flavonoid fisetin (3,3',4',7-tetrahydroxyflavone) is neurotrophic and prevents fibril formation of amyloid beta protein (A beta). It is a promising lead compound for the development of therapeutic drugs for Alzheimer's disease. To find...
Currently, the major drug discovery paradigm for neurodegenerative diseases is based upon high affinity ligands for single disease-specific targets. For Alzheimer's disease (AD), the focus is the amyloid beta peptide (A beta) that mediates familia...
AMERICAN JOURNAL OF RHINOLOGY 20(3) 336-341 2006年5月
Background: Nitric oxide (NO) is produced by the action of NO synthase (NOS) isoforms and is considered an important mediator Of inflammatory response including airways. In this study, the changes in the expression levels of NOS isoforms in nasal ...
Y Niikura   K Abe   M Misawa   
BRAIN RESEARCH 1017(1-2) 218-221 2004年8月
We have recently found that synaptic pathway from the basolateral amygdala (BLA) to the dentate gyrus (DG) displays N-methyl-D-aspartate (NMDA) receptor-in dependent form of long-term potentiation (LTP), which should be a valuable model for elucid...
Journal of smooth muscle research = Nihon Heikatsukin Gakkai kikanshi 40(1) 25-34 2004年2月
While nonspecific airway hyperresponsiveness (AHR) is a central feature of allergic bronchial asthma, the mechanism underlying the development of AHR is not clearly understood. We have previously demonstrated in vitro hyperresponsiveness of bronch...
K Abe   Y Niikura   M Misawa   
NEUROSCIENCE 125(1) 113-117 2004年
Although ethanol has been reported to inhibit the induction of long-term potentiation in hippocampal CA1 and dentate gyrus synapses of rats, very little is known about the effect of ethanol on synaptic plasticity in other brain regions. Therefore,...