Drug Metabolism and Pharmacokinetics 34(4) 233-238 2019年8月 [査読有り]
Creatinine is excreted into urine by glomerular filtration and renal tubular secretion through drug transporters such as organic anion transporter 2 (OAT2), organic cation transporter 2 (OCT2), OCT3, multidrug and toxin extrusion protein 1 (MATE1)...
British Journal of Clinical Pharmacology 85(7) 1454-1463 2019年7月 [査読有り]
AIMS: Vonoprazan, a new class of potassium-competitive proton pump inhibitors has been found to attenuate the antiplatelet function of clopidogrel in a recent clinical study, despite weak in vitro activity against CYP2C19. To elucidate the mechani...
A chemoselective demethylation method for various methoxypyridine derivatives has been developed. Treatment of 4-methoxypyridine with L-selectride in THF for 2 h at reflux temperature afforded 4-hydroxypyridine in good yield; no reaction to anisol...
Ryo Fujino   Kenta Hashizume   Shinsuke Aoyama   Kazuya Maeda   Kiyomi Ito   Kota Toshimoto   Wooin Lee   Shin-ichi Ninomiya   Yuichi Sugiyama   
European Journal of Pharmaceutical Sciences 125 181-192 2018年12月 [査読有り]
The antidiabetic drugs glibenclamide, repaglinide, and nateglinide are well-known substrates for hepatic uptake transporters of the organic anion transporting polypeptide (OATP) family and metabolizing enzymes of the cytochrome P450 (CYP) 2C subfa...