Drug Metabolism and Pharmacokinetics 33(1) 103-110 2018年2月 [査読有り]
Serum creatinine (SCr) levels rise during trimethoprim therapy for infectious diseases. This study aimed to investigate whether the elevation of SCr can be quantitatively explained using a physiologically-based pharmacokinetic (PBPK) model incorpo...
Toshiyuki Kudo   Hitomi Goda   Yuki Yokosuka   Ryo Tanaka   Seina Komatsu   Kiyomi Ito   
Journal of Pharmaceutical Sciences 106(9) 2847-2852 2017年9月 [査読有り]
We have previously reported that the microsomal activities of CYP2C8 and CYP3A4 largely depend on the buffer condition used in in vitro metabolic studies, with different patterns observed between the 2 isozymes. In the present study, therefore, th...
Toshiyuki Kudo   Yuya Ozaki   Tomomi Kusano   Eri Hotta   Yuka Oya   Seina Komatsu   Hitomi Goda   Kiyomi Ito   
XENOBIOTICA 46(3) 241-246 2016年3月 [査読有り]
1.Buffer conditions in in vitro metabolism studies using human liver microsomes (HLM) have been reported to affect the metabolic activities of several cytochrome P450 (CYP) isozymes in different ways, although there are no reports about the depend...