INTERNATIONAL JOURNAL OF PHARMACEUTICS 495(2) 963-971 2015年11月 [査読有り]
In a transcellular transport study, the apparent permeability coefficient (P-app) of a compound is evaluated using the range by which the amount of compound accumulated on the receiver side is assumed to be proportional to time. However, the time ...
JOURNAL OF PHARMACEUTICAL SCIENCES 104(9) 3183-3193 2015年9月 [査読有り]
The purpose of this study was to predict the drug-drug interactions (DDIs) via CYP3A4 by estimating the extent of hepatic CYP3A4 inhibition based on a physiologically based pharmacokinetic (PBPK) model of both substrate and inhibitor and the incre...
Toshiyuki Kudo Yumiko Endo Rina Taguchi Masami Yatsu Kiyomi Ito
XENOBIOTICA 45(5) 413-419 2015年5月 [査読有り]
1. Blood levels of S-warfarin have been reported to be increased by concomitant administration of metronidazole (MTZ),an antiprotozoal imidazole derivative.
2. To elucidate the mechanism of this interaction and to identify other possible drug-drug...
Toshiyuki Kudo Akihiro Hisaka Yuichi Sugiyama Kiyomi Ito
DRUG METABOLISM AND DISPOSITION 41(2) 362-371 2013年2月 [査読有り]
The plasma concentration of repaglinide is reported to increase greatly when given after repeated oral administration of itraconazole and gemfibrozil. The present study analyzed this interaction based on a physiologically based pharmacokinetic (PB...
Metronidazole (MTZ) ointment has been used widely as a hospital preparation against cancerous malodor. Although cancerous tissue with ulcer-like symptoms is likely to have a higher capacity to absorb drugs than normal skin, the extent to which MTZ...
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