Nobutomo Ikarashi Takahiro Toda Takehiro Okaniwa Kiyomi Ito Wataru Ochiai Kiyoshi Sugiyama
Evidence-based complementary and alternative medicine : eCAM 2011 952031-952031 2011年
Acacia polyphenol (AP) extracted from the bark of the black wattle tree (Acacia meansii) is rich in unique catechin-like flavan-3-ols, such as robinetinidol and fisetinidol. The present study investigated the anti-obesity/anti-diabetic effects of ...
DRUG METABOLISM AND PHARMACOKINETICS 26(6) 612-620 2011年 [査読有り]
The purpose of this study was to provide a pharmacokinetics/pharmacodynamics and toxicokinetics/toxicodynamics bridging of kinase inhibitors by identifying the relationship between their clinical and preclinical (rat, dog, and monkey) data on expo...
TRENDS IN PHARMACOLOGICAL SCIENCES 31(8) 351-355 2010年8月 [査読有り]
Quantitative prediction of the in vivo drug drug interactions (DDIs) caused by metabolic inhibition, one of the most common DDI mechanisms in clinical practice, has long been challenged. The DDI-induced increase in the area under the plasma concen...
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