Tomohisa Nakada   Toshiyuki Kudo   Kiyomi Ito   
Drug metabolism and disposition: the biological fate of chemicals 2023年3月
Creatinine is a common biomarker of renal function and is secreted in the renal tubular cells via drug transporters such as organic cation transporter 2 and multidrug and toxin extrusion (MATE) 1/2-K. To differentiate between drug-induced acute ki...
Toshiyuki Hikita   Hitomi Goda   Yasuko Ogawa   Toshiyuki Kudo   Kiyomi Ito   
Pediatrics international : official journal of the Japan Pediatric Society 65(1) e15429 2023年1月
BACKGROUND: Caffeine consumption is a risk factor for chronic daily headache but few studies have addressed relationships between pediatric patient caffeine levels and headache severity. We examined associations between serum and urine caffeine le...
Kazuya Maeda   Akihiro Hisaka   Kiyomi Ito   Yoshiyuki Ohno   Akihiro Ishiguro   Reiko Sato   Naomi Nagai   
Drug metabolism and pharmacokinetics 41 100414-100414 2021年12月
During new drug development, clinical drug interaction studies are carried out in accordance with the mechanism of potential drug interactions evaluated by in vitro studies. The obtained information should be provided efficiently to medical expert...
Drug metabolism and pharmacokinetics 41 100422-100422 2021年12月
Rilpivirine is a non-nucleoside reverse transcriptase inhibitor, used for the treatment of human immunodeficiency virus type-1 infection. An open label study was conducted to investigate the pharmacokinetics (PK) and safety of a single oral dose o...