BRITISH JOURNAL OF PHARMACOLOGY 174(19) 3370-3381 2017年10月 [査読有り]
BACKGROUND AND PURPOSE
Visceral hypersensitivity is responsible for pathogenesis of irritable bowel syndrome (IBS). Therefore, its prevention can help avoid abdominal pain and discomfort in IBS. To find candidate drugs for visceral hypersensitivit...
M. Kawahara   M. Kato-Negishi   K. Tanaka   
METALLOMICS 9(6) 619-633 2017年6月 [査読有り]
Increasing evidence suggests that disruption of metal homeostasis contributes to the pathogenesis of various neurodegenerative diseases, including Alzheimer's disease, prion diseases, Lewy body diseases, and vascular dementia. Conformational chang...
Idiopathic pulmonary fibrosis (IPF) involves alveolar epithelial injury and abnormal collagen production caused by activated fibroblasts; transforming growth factor (TGF)-beta 1 is implicated in this activation. In this study, we screened for chem...
Zinc (Zn), an essential trace element, is secreted by synaptic vesicles during neuronal excitation and plays several critical roles in neuronal information processing. However, excess Zn ion (Zn2+) is neurotoxic and has a causative role in the pat...
AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY 56(2) 179-190 2017年2月 [査読有り]
For acute respiratory distress syndrome (ARDS), mechanical ventilation (MV) is a life-saving intervention without alternative; however, MV can cause ventilator-induced lung injury. Reactive oxygen species (ROS) play important roles in the pathogen...